Primary syphilis presenting as a painful unilateral inguinal lymphadenopathy, without cutaneous manifestations, in a 71-year-old Japanese man: A case report

Yorita, Kenji; Ito, Chikane; Fujioka, Ai; Kashiwagi, Keisuke; Yamai, Hiromichi; Nakatani, Kimiko; Kumon, Tatsuya

doi:10.1016/j.radcr.2022.10.045

Cited by 1 publication

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References 6 publications

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“…However, these tests are routinely unavailable, requiring special equipment and considerable experience and expertise to interpret the results. Warthin‐Starry silver staining and immunocytochemical and immunohistochemical study using anti‐ T. pallidum antibodies are useful and routinely available 4,5,13 . However, the sensitivity for detecting the organisms by Warthin‐Starry silver staining was shown to be lower than that of immunohistochemistry 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Warthin-Starry silver staining and immunocytochemical and immunohistochemical study using anti-T. pallidum antibodies are useful and routinely available. 4,5,13 However, the sensitivity for detecting the organisms by Warthin-Starry silver staining was shown to be lower than that of immunohistochemistry. 14 Polymerase chain reaction testing to detect T. pallidum DNA is also useful but routinely unavailable as there are no commercially available test kits.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic utility of fine‐needle aspiration cytology in syphilitic lymphadenitis: A case report

Yorita

Ohara

Tahara

et al. 2023

Diagnostic Cytopathology

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Syphilis is a sexually transmitted infection that causes serious health problems without treatment. Detection of syphilis is necessary to stop the spread of the infection.Cytological screeners and pathologists may experience fine-needle aspiration cytology (FNAC) for syphilitic lymphadenitis; however, its characteristic cytological features are rarely reported. We present FNAC cytological features of syphilitic lymphadenitis in a case of a 21-year-old man. He presented with a sore throat and painful neck lymphadenopathy. His swollen and painful neck persisted even with antibiotic treatment. Necrotizing lymphadenitis and lymphoma were clinically suspected. FNAC was taken from the swollen lymph node. Cytologic findings of the specimen showed various inflammatory cells with small-sized vessels arranged in a branching/arborizing fashion. The vessels were surrounded by inflammatory cells, including plasma cells, neutrophils, and macrophages. Perivascular plasma cell cuffing was focally seen along with inconspicuous granulomas. Neutrophils appeared to involve the vascular wall. The cytological findings suggested syphilitic lymphadenitis, and clinical findings and serological tests confirmed primary syphilis with concomitant human immunodeficiency virus infection. Branching/arborizing vessels associated with many plasma cells, vascular involvement of neutrophils, and granulomas may suggest syphilitic infection if the specimen is obtained via FNAC.

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Section: Discussionmentioning

confidence: 99%