Primary Synovial Sarcoma of the Thyroid Gland: A Case Report and Review of Literature

Zahran, Mohamed; Hamza, Ashraf; Alsedra, Sundus; Youssef, Ahmed

doi:10.1007/s12070-020-01999-3

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Primary synovial cell sarcoma of thyroid is exceedingly rare. To our knowledge, only 11 cases have been reported in the English literature [1] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] . Herein, we describe the twelfth case of primary synovial cell sarcoma of thyroid with a literature review.…”

Section: Introductionmentioning

confidence: 99%

Primary synovial sarcoma of thyroid gland: A case report and review of literature

Seyed-alagheband

Sharifian

Adeli

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Herein, we describe the twelfth case of primary synovial cell sarcoma of thyroid with a literature review. Case presentation A 43-year-old woman presented with complaint of a progressive neck mass for the last five-months. She developed with dysphagia and dyspnea nearly 2 months prior, without signs of hoarseness, and weight loss. Ultrasonography in which revealed a heterogeneous, hypervascularized thyroid mass. After total thyroidectomy immunohistochemistry was in favor of primary synovial cell sarcoma of thyroid. The diagnosis was confirmed via Molecular genetic analysis of the SYT-SSX fusion gene transcript using the RT- polymerase chain reaction method. Clinical Discussion: Primary thyroid SVS is an extremely rare malignancy with poor biological behavior. SVS has been known for its tendency to local and distal re-occurrence after a few years of treatment. SS can be classified into two subtypes of monophasic or biphasic based on the presence of mesenchymal and/or epithelial components. Accordingly, the most accurate diagnostic tool for SS is considered to be molecular genetic analysis for SYT/SSX fusion transcript. Conclusion Herein, we reported an extremely rare case of SVS of thyroid gland. These high-grade soft tissue sarcomas mainly present with an asymptomatic rapid growing neck mass. Unspecific clinical presentations and extreme rarity of this disorder, make the diagnosis of thyroid SVS very challenging. Due to paucity of data, there is not enough evidence to establish a reliable mortality rate. However, the prognosis of thyroid SVS seems unfavorable.

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Section: Introductionmentioning

confidence: 99%

Primary synovial sarcoma of thyroid gland: A case report and review of literature

Seyed-alagheband

Sharifian

Adeli

et al. 2021

International Journal of Surgery Case Reports

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Case report of primary synovial sarcoma of the thyroid gland: An unusual histology at atypical location

Lekshmi

Gupta

Pabi

et al. 2023

J Indian Assoc Pediatr Surg

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A BSTRACT Primary synovial sarcoma of the thyroid gland is extremely rare, aggressive, and has a dismal prognosis. We report the case of a 15-year-old male who presented with a progressively increasing neck mass, which was excised and the histopathological and immunohistochemical study suggested biphasic synovial sarcoma of the thyroid gland which was confirmed by synovial sarcoma translocation. There are 14 cases of primary synovial sarcoma of the thyroid reported in the literature so far. This study aimed to document the occurrence of synovial sarcoma histology at an unusual anatomical location with a review of the literature on this rare entity.

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Primary Synovial Sarcoma of the Thyroid Gland: A Case Report and Review of Literature

Cited by 2 publications

References 13 publications

Primary synovial sarcoma of thyroid gland: A case report and review of literature

Primary synovial sarcoma of thyroid gland: A case report and review of literature

Case report of primary synovial sarcoma of the thyroid gland: An unusual histology at atypical location

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