Primary Synovial Sarcoma of the Kidney: A Rare Presentation

Puj, Ketul; Pandya, Shashank; Warikoo, Vikas; Chauhan, Tapansingh; Samanta, Satarupa

doi:10.1016/j.urology.2017.12.017

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…Puj et al. [12] described a case of large renal synovial sarcoma treated with neoadjuvant ifosfamide and doxorubicin chemotherapy that resulted in the downstaging of the tumor and made surgical resection possible. Another case report by Chediak et al.…”

Section: Discussionmentioning

confidence: 99%

A rare case report of recurrent primary intra-abdominal synovial sarcoma: An unusual manifestation

Zahra,

Kanwal,

Khalid

et al. 2024

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

A rare case report of recurrent primary intra-abdominal synovial sarcoma: An unusual manifestation

Zahra,

Kanwal,

Khalid

et al. 2024

Radiology Case Reports

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“…Chediak et al reported complete resolution of a metastatic renal synovial sarcoma with surgery and doxorubicin and ifosfamide chemotherapy [2]. Puj et al described a case of large renal synovial sarcoma in which they used ifosfamide and doxorubicin chemotherapy in the neoadjuvant setting which resulted in down staging of the tumor and subsequent surgical resection possible [9]. We used renal artery embolization in the preoperative setting to facilitate its resection as it was a massive tumor and sub hepatic plane was not clear.…”

Section: Discussionmentioning

confidence: 99%

Primary synovial sarcoma of kidney: a rare case report with review of literature

et al. 2022

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Background Synovial sarcoma is a rare type of sarcoma with a predilection for extremities in young adults. Very rarely this tumor can originate from kidney. Case presentation A 22-year-old female presented to us with complaints of right flank pain and a large mass in the right side of abdomen for the last 6 months. A provisional diagnosis of renal cell carcinoma was made and right radical nephrectomy was done. However on histopathological examination the tumor was composed of spindle cells arranged in hemangiopericytoma-like vascular pattern. Immunohistochemistry and FISH confirmed the diagnosis of synovial sarcoma of kidney. The patient had no signs of recurrence or metastasis at six months of follow-up. Conclusion Renal synovial sarcomas, though rare, should be considered as a differential in young adults who present with extremely large renal mass. Surgical extirpation is the treatment of choice. Ifosfamide- and doxorubicin-based chemotherapy can be given in non resectable and metastatic cases.

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“…They predominantly arise from the soft tissue proximal to joints and the tendons of the limbs but can also arise as primary lesions in various other sites including head and neck, abdominal wall, vulva, penis, kidney, heart, lungs, retroperitoneum, skin, pelvis, prostate, intra-cranial and intra-neural regions. 5,6 Primary renal synovial sarcoma is one of the rarest types of sarcomas of kidney and comprises 2% of all malignant renal tumors and 1% of all synovial sarcomas across the anatomic sites. 7 The first case of primary renal synovial sarcoma was reported by Argani et al in 2000 and to date, 88 case reports and 23 case series, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] with only two case series consisting of more than 14 tumors, have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 The most common presenting symptoms include hematuria, pain, and palpable mass. 6 Histologically, they can be monophasic type with spindle cell morphology which is the most common histologic pattern, followed by biphasic type with spindle and epithelial morphology, and poorly differentiated type. In biphasic type, the epithelial component is thought to occur due to entrapment of renal epithelium.…”

Section: Introductionmentioning

confidence: 99%

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SS18-SSX Expression in a Contemporary Cohort of Primary Renal Synovial Sarcoma: A Multi-Institutional Experience of Fourteen Patients

Challa

Mohanty²,

Jha³

et al. 2023

Int J Surg Pathol

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Primary renal synovial sarcoma is a rare aggressive mesenchymal neoplasm of the kidney that accounts for less than 1% of renal sarcomas. Herein, we describe the clinicopathologic and molecular findings of 14 renal synovial sarcoma patients in one of the largest case series to date and to our knowledge, the only renal synovial sarcoma series to use novel SS18-SSX IHC. Clinicopathologic, IHC, molecular, management, and follow-up data were reviewed and analyzed. Macroscopically, the tumors had either homogeneous, tan-white, and solid ( n = 10), variegated and solid ( n = 3), or variegated and solid-cystic ( n = 1) cut surfaces. Spindle cell ( n = 10), round cell ( n = 3), and round to epithelioid morphologies ( n = 1) were observed. SS18-SSX IHC was positive in all 14 tumors (diffuse, n = 10; multifocal, n = 2; focal, n = 2). All the tumors harbored SS18::SSX1/2 gene rearrangement. Metastases to the liver, brain, and lung ( n = 1); liver and bone ( n = 1); liver and diaphragm ( n = 1) were identified. Adjuvant chemotherapy was administered in 11/12 patients. Follow-up was available for 10 patients (time period range: 5 to 24 months). Four patients died of disease, and six patients are alive with no recurrence or metastasis. As SS18-SSX IHC showed an excellent concordance with the FISH results, this may reliably be used in the IHC panel of spindle/round cell sarcomas of the kidney and as a molecular surrogate for renal synovial sarcoma, particularly in a resource-limited setting. Also, the tumors with focal SS18-SSX expression had lower break apart signals in the FISH assay (19% and 23% in two tumors with focal SS18-SSX IHC positivity).

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Primary Synovial Sarcoma of the Kidney: A Rare Presentation

Cited by 7 publications

References 5 publications

A rare case report of recurrent primary intra-abdominal synovial sarcoma: An unusual manifestation

A rare case report of recurrent primary intra-abdominal synovial sarcoma: An unusual manifestation

Primary synovial sarcoma of kidney: a rare case report with review of literature

SS18-SSX Expression in a Contemporary Cohort of Primary Renal Synovial Sarcoma: A Multi-Institutional Experience of Fourteen Patients

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