Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential

Davis, R. I.; Hamilton, Amber; Biggart, J. D.

doi:10.1016/s0046-8177(98)90276-3

Cited by 259 publications

(190 citation statements)

References 25 publications

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“…As with other case reports on malignant transformation, all of these cases were in large joints [3,5,17,21,24]. To our knowledge, no cases of malignant transformation have been seen in the finger joints.…”

Section: Discussionsupporting

confidence: 81%

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Synovial Chondromatosis in a Child's Thumb: A Case Report and Review of the Literature

Gottschalk

Newbury

Wallace

2011

Hand (New York, N,Y.)

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Section: Discussionsupporting

confidence: 81%

“…Males are affected more than females, commonly ranging in age from the third to fifth decade of life [3,12,13,18]. Typically large joints are involved with the knee being the most common, followed by the hip and elbow [3,8,15,16,18,19,26].…”

Section: Discussionmentioning

confidence: 99%

Synovial Chondromatosis in a Child's Thumb: A Case Report and Review of the Literature

Gottschalk

Newbury

Wallace

2011

Hand (New York, N,Y.)

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“…The treatment often involves removal of loose bodies and subtotal synoviectomy, with or without joint replacement. Local recurrence is possible after incomplete synoviectomy, inadequate removal of loose bodies or diseased synovium at the time of initial surgery (28,32,43) and it is estimated to be 23% (53).…”

Section: Resultsmentioning

confidence: 99%

“…This risk ranges from 1% to 5% according different case series (28,36,53). As the clinical and radiological features are very similar between SC and SCH, their differentiation is often difficult and represents a diagnostic problem for orthopedic surgeon, radiologist and pathologist.…”

Section: Resultsmentioning

confidence: 99%

Synovial chondrosarcoma

Biazzo¹,

Confalonieri²

2016

Ann. Transl. Med.

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Background: Synovial chondrosarcoma (SCH) is a very rare tumor arising in the intra-articular cavity. In the majority of literature reports it is described as a malignant transformation of a pre-existing synovial chondromatosis (SC). We reported a systematic review of primary and secondary SCH described in the literature with the aim to recollect data from different case-reports and case-series, trying to summarize general aspects of this very rare disease. Methods:We collected 42 abstracts in the form of case series and case reports, which reported 67 cases of SCH.Studies were taken into account only if they proved a histological diagnosis of SCH, either primary or secondary, with or without evidence of pre-existing SC.Results: The average age of SCH was 56.9 years, with prevalence for male sex. The average time of malignant transformation was 11.2 years. The most affected joint was the knee (47.7%), followed by hip (34.3%) and ankle (5.9%). SCH was described as de novo sarcoma only in 13 cases (19%). Surgery ended up with amputation in 59.7% of cases. Local recurrence rate was 28.3%. Conclusions:We concluded that prognosis of SCH is worse than conventional one and we speculated this is due to the difficult site of the tumor (intraarticular), diagnostic delay and inappropriate previous treatments. We consider that a rapid deterioration of a SC or rapid recurrence after synoviectomy should be considered suspicious of malignant transformation and should be treated in a reference center.

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“…Malignant transformation of synovial chondromatosis to chondrosarcoma is documented but rare (1,2). The clinical features alone are not helpful for distinguishing them, and no definite imaging criteria can differentiate synovial chondromatosis from low-grade synovial chondrosarcoma (2)(3)(4)(5).…”

mentioning

confidence: 99%