Primary stromal sarcoma of the breast

Radovanović, Anita; Gligorijević, Jasmina; Živković, Nikola; Andjelkovic-Matic, Marija

doi:10.2298/aoo1202024r

Cited by 7 publications

(14 citation statements)

References 21 publications

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“…Malignant diseases of the breast are the most common oncological diseases in women. 9 They have most frequently epithelial origin (carcinomas) and very rarely a mesenchymal one (sarcomas). 10 The primary sarcoma of breast represents a very rare morbid entity, while several hundred cases of that kind were described in the world scientific literature until now.…”

Section: Discussionmentioning

confidence: 99%

“…10 The primary sarcoma of breast represents a very rare morbid entity, while several hundred cases of that kind were described in the world scientific literature until now. 9 That disease most frequently affects women from 50-70 years of age, while in principle it may occur in people of all ages. 11 We must note that the primary sarcoma of breast is also observed in men, while its frequency is 5 per cent of all resemblant sarcomas.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The most common subtypesbased on anatomic pathology -are fibrous histiocytoma, fibrosarcoma, angiosarcoma, and spindle cell sarcoma. 9 There are some immunohistochemical markers that can improve diagnose as CD10, CD29, vimentin, SMA p63, calponin, EGFR. 11 The risk factors for the development of sarcoma of the breast are not completely explicit, but the most frequent among them are the previous fibroadenoma of breast, external ionizing radiation, lymphedema of the breast, neurofibromatosis, etc.…”

Section: Discussionmentioning

confidence: 99%

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Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast

Strashilov¹,

Yordanov²,

Slavchev³

et al. 2019

amj

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Please cite this paper as: Strashilov S, Yordanov A, Slavchev S, Nanev V, Ivanova D, Ivanov M, Ivanov I. Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast -A clinical case. AMJ 2019;12(9):251-254. ABSTRACTThe primary sarcoma of breast is a rare malignant tumour, which develops from the mesenchymal tissue of the mammary gland. It represents less than 1 per cent of all malignant diseases of the breast. The incidence is about 17 new cases per 1 000 000 women. The aetiology of that disease is unknown. The main method of treatment is the surgical excision with which includes the "safety-margin" of healthy-looking tissues.We present a 57-year-old woman with probably familial, primary, malignant malignant phyllodes sarcoma. Her niece was diagnosed with periductal stromal sarcoma of the left breast five years ago. This evoked in us the idea that there is probably a familial connection between the two diseases.After radical surgery the patient was undergone to radiotherapy and she is without any signs of recurrence till now. Key WordsMalignant phyllodes sarcoma, stromal sarcoma of breast, sarcoma of the breast Implications for Practice:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast

Strashilov¹,

Yordanov²,

Slavchev³

et al. 2019

amj

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show abstract

“…PBS is a rare and very aggressive entity, comparable to other soft tissue sarcomas and is totally independent of epithelial breast cancers [9, 11]. Due to its rarity, there is no sufficient knowledge to support consensus regarding best management [8].…”

Section: Discussionmentioning

confidence: 99%

“…They can appear as primary forms or secondary to radiation therapy or chronic lymphedema [3, 8]. Primary breast sarcomas (PBS) are malignant tumors arising from the connective tissue within the breast and account for less than 1% of breast cancer and no more than 5% of all sarcomas [1, 9]. The published literature regarding breast sarcomas is predominantly composed of small retrospective analyses and case reports.…”

Section: Introductionmentioning

confidence: 99%

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Ramalho¹,

Campos²,

Rebelo³

et al. 2016

Case Rep Oncol

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Primary breast sarcoma, arising from connective tissue within the breast, is extremely rare, accounting for less than 1% of all primary breast malignancies and no more than 5% of all sarcomas. The rarity of this pathology limits most studies to case reports and small retrospective studies, which has led to a lack of consensus on the clinical management. We report a clinical case of a 52-year-old woman, perimenopausal, previously healthy, with regular breast surveillance, who presented with a large (>20 cm) and rapidly expanding hypervascularized tumor of the left breast developed over 10 days, with a very thin preulcerative skin over the last 4 days. There was no systemic dissemination. The patient was submitted to total mastectomy and excision of axillary adenopathy. The tumor was diagnosed histologically as malignant phyllodes tumor associated with areas of high-grade sarcoma. Due to rapid growth and aggressive histological characteristics, adjuvant chemotherapy and radiotherapy were performed. There is a lot of evidence that tumors larger than 5 cm are associated with a poor prognosis. Despite the poor prognosis associated with this aggressive entity, the patient had no recurrence during 5 years of follow-up. We review the relevant literature about primary breast sarcomas.

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Role of p63 expression in non-proliferative and proliferative lesions of breast

et al. 2018

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Background: Breast lump among females, is a fairly common complaint. Breast lump have a variety of etiologies ranging from inflammatory to benign to malignant lesions. Myoepithelial markers are useful in helping to distinguish invasive carcinoma from benign proliferations with a similar morphological appearance, benign proliferative lesions and most pre-invasive lesions with an intact myoepithelium. Invasive carcinomas lack the myoepithelial cell layer that normally surrounds benign breast glands. p63 antibody is a myoepithelial cell marker that selectively stains nuclei. Also, it is negative in stromal, myofibroblastic and adipocytic cells. This makes p63 more specific and superior to other myoepithelial markers.Methods: The present study was done on a total of 151 cases of breast diseases, received in the form of core biopsy, tru cut biopsy, lumpectomy, and mastectomy specimens. Clinical history and examination findings of the patients were collected in all the cases. All specimens were routinely processed and stained with haematoxylin and Eosin (H and E) stain and only 50 cases were subjected to immunohistochemical staining for p63.Results: Out of total 151 cases, 09 were inadequate for evaluation, 96 cases benign and 46 malignant. In benign category, fibroadenoma was most common and infiltrating ductal carcinoma (NOS) was the most common in malignant category. Mean size of benign tumors was found to be less than that of malignant tumors. All malignant cases were negative for p63 expression. In the benign category, 88.6% cases showed positive expression for p63 while 11.4% were negative. Among the benign category, non-proliferative lesions were continuous positive, proliferative showed discontinuous positivity for p63.Conclusions: Myoepithelial markers are useful in helping to distinguish invasive carcinoma from benign proliferations with a similar morphological appearance, benign proliferative lesions and most pre-invasive lesions with an intact myoepithelium. Invasive carcinomas lack the myoepithelial cell layer while in the benign category, non-proliferative lesions are continuous positive, proliferative lesions show discontinuous positivity for p63.

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Primary stromal sarcoma of the breast

Abstract: Primary sarcomas of the breast are rare and there are only a few hundred cases reported in the literature; hence, their significance is primarily educational. We report a case of a 57-year old patient who developed breast sarcoma without previous history on any breast diseases

Cited by 7 publications

References 21 publications

Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast

Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Role of p63 expression in non-proliferative and proliferative lesions of breast

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