Primary Stenting in Femoropopliteal Occlusive Disease　– What Is the Appropriate Role? –

Yiu, Wai-ki; Conte, Michael S.

doi:10.1253/circj.cj-15-0199

Cited by 10 publications

(4 citation statements)

References 39 publications

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“…Critical limb ischemia is the most severe form of PAD, and mortality rates reach up to 20% in the first 6 months after diagnosis . Despite improved health care for atherosclerosis and subsequent increased survival in PAD patients, morbidity and mortality risks in PAD patients are still high . Patients with critical limb ischemia are at particularly high risk of major amputation.…”

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confidence: 99%

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Haan

Haitjema

Ruijter

et al. 2017

JAHA

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BackgroundPeripheral artery disease (PAD) is one of the most common clinical presentations of atherosclerosis, and its prevalence is still increasing. Despite improvement of health care, morbidity and mortality risks remain high, including the risk of amputation. GDF15 (growth differentiation factor 15) is a member of the transforming growth factor family that is involved in apoptosis and inflammation; therefore, GDF15 is a potential biomarker to identify patients at high risk of adverse clinical outcomes.Methods and ResultsCirculating GDF15 levels were measured using a multiplex immunoassay in patients with critical limb ischemia and PAD from 2 different patient cohorts that included patients with clinically manifest PAD: the JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra‐Arterial Supplementation) trial (n=160, 67 major events; critical limb ischemia) and the Athero‐Express Biobank (n=386, 64 major events; PAD). Kaplan–Meier curves demonstrated that high levels of GDF15 were associated with increased risk of major events, defined as major amputation (at or above the ankle joint) and all‐cause mortality, in both cohorts (highest versus lowest, JUVENTAS: hazard ratio: 4.01 [95% confidence interval, 2.05–7.84; P<0.0001]; Athero‐Express: hazard ratio: 3.27 [95% confidence interval, 1.64–6.54; P=0.0008]). In the JUVENTAS trial, this was more pronounced in women. Cox proportional multivariable regression models with median follow‐up of 3 years, corrected for common confounders, showed hazard ratios of 1.70 (95% confidence interval, 1.18–2.69; P=0.0053) and 1.57 (95% confidence interval, 1.02–2.41; P=0.041) per 2.78‐fold increase of GDF15 in JUVENTAS and Athero‐Express, respectively.ConclusionsHigh GDF15 levels are associated with increased risk of major amputation and/or death in PAD patients. GDF15 levels could be of additive value to identify patients who are at high risk of amputation or death and could help guide treatment choices.

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confidence: 99%

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Haan

Haitjema

Ruijter

et al. 2017

JAHA

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“…CS combines a self-expanding stent with expanded polytetrafluoroethylene and aims to reduce in-stent restenosis and distal embolization by preventing the ingrowth of neointimal tissue into the stent and covering the ulcerated segments of vessels. Contoured proximal edge, heparin bioactive surface, and the introduction of 5-mm-diameter stent graft all aim to reduce the risk of edge stenosis and stent thrombosis [9].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Intervention of Iatrogenic Iliac Artery Vascular Complication

Siddiqui

Ayzenberg

Morshed

et al. 2020

Cureus

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The mortality of patients from a retroperitoneal hematoma remains high if treatment is delayed or inappropriate. Percutaneous endovascular repair of iatrogenic vascular complications is quickly becoming the treatment of choice. Here, we report a case of a 76-yearold female with a non-ST-elevation myocardial infarction, whose cardiac catheterization revealed a 70% distal left main coronary artery (LMCA) stenosis. She underwent successful rotational atherectomy and deployment of drug-eluting stents of the distal LMCA. Following percutaneous coronary intervention, she suffered acute profound hypotension and was found to have a retroperitoneal hematoma. Given the high cardiac risk for vascular surgery due to recent intervention and overall comorbidities, she was immediately taken to the cardiac catheterization laboratory and had a diagnostic angiogram, which revealed a right external iliac artery perforation that was treated with a covered stent. She tolerated the procedure well. This case highlights the importance of early diagnosis of retroperitoneal bleed, the prompt decision to take the patient to the cardiac catheterization laboratory, and potential use of intravascular interventions to ensure a successful outcome.

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“…Patients with peripheral arterial disease (PAD) have an increased risk of cardiovascular events (CVE) and death. [1][2][3] Current population trends show a predicted increase in patients with PAD worldwide owing to the ageing population and increased prevalence of diabetes. 4,5 Although patients often suffer from wellrecognized clinical risk factors to develop primary CVE, 6 plaque characteristics may contain additional valuable information regarding the risk to develop secondary CVE or the need for re-interventions.…”

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confidence: 99%

Atherosclerotic plaque characteristics are not associated with future cardiovascular events in patients undergoing iliofemoral endarterectomy

Haelst

Haitjema

Derksen

et al. 2018

Journal of Vascular Surgery

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Primary Stenting in Femoropopliteal Occlusive Disease　– What Is the Appropriate Role? –

Cited by 10 publications

References 39 publications

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Percutaneous Intervention of Iatrogenic Iliac Artery Vascular Complication

Atherosclerotic plaque characteristics are not associated with future cardiovascular events in patients undergoing iliofemoral endarterectomy

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Primary Stenting in Femoropopliteal Occlusive Disease – What Is the Appropriate Role? –

Cited by 10 publications

References 39 publications

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease

Percutaneous Intervention of Iatrogenic Iliac Artery Vascular Complication

Atherosclerotic plaque characteristics are not associated with future cardiovascular events in patients undergoing iliofemoral endarterectomy

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Primary Stenting in Femoropopliteal Occlusive Disease　– What Is the Appropriate Role? –