Primary staging and follow-up of high risk melanoma patients with whole-body18F-fluorodeoxyglucose positron emission tomography

Abstract

ported to be a sensitive method for detecting malignant melanoma metastases. METHODS. One hundred consecutive patients with high risk melanoma (tumor Gustav RESULTS.In Group A, the sensitivity of PET was 100% and the specificity was 94%, whereas CD did not identify any of the 9 lymph node metastases and demonstrated 2 Department of Nuclear Medicine, University of Frankfurt Medical Center, Frankfurt, Germany.a lower specificity (80%). In Group B, 121 lesions were detected, 111 by PET and 69 by conventional imaging. On the basis of patients, the sensitivity, specificity, and accuracy of PET were 100%, 95.5%, and 97.9%, respectively (91.8%, 94.4%, and 92.1%, respectively, on the basis of single metastases). Prospectively, CD did not identify all patients with progression (sensitivity, 84.6%) and detected significantly fewer metastases (sensitivity, 57.5%) with much lower specificity (68.2% on the basis of patients, 45% on the basis of single lesions); therefore, the accuracy of CD was 77.1% on the basis of patients and only 55.7% on the basis of single metastases.Results also depended on specific sites: while PET yielded a higher sensitivity in detecting cervical metastases (100% vs. 66.6%) and abdominal metastases (100% vs. 26.6%), computed tomography proved to be superior in detecting small lung metastases (87% vs. 69.6%). utaneous malignant melanoma causes more than 75% of all skin cancer deaths, and its incidence is rapidly rising in white popula- hand, when managing patients with advanced tumors bearing a high risk for locoregional or systemic spread, one major objective is the CONCLUSIONS. PET is a highly sensitive and

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

“…Results, however, depend on the experience of the examiner. The sensitivity of PET/MRT/CT is greater than that of abdominal sonography [626]. In a study by Kaufmann et …”

“…Systematic search of the literature de-novo: [116,614,625,626] Strength of consensus: 96 % I. Satzger, U. Leiter…”

The impact of 18-fluorodeoxyglucose positron emission tomography on the staging, management and outcome of anal cancer

“…The fact that PET imaging is functional rather than structural limits its value in local tumour staging, but numerous studies have shown an effect in the identification of regional and distant disease (Rinne et al, 1998;Dwamena et al, 1999;Gould et al, 2001;Hellwig et al, 2001;Kalff et al, 2002), treatment decisions (MacManus et al, 2001;Spaepen et al, 2001;Blum et al, 2003;Heriot et al, 2004), radiotherapy planning (Haustermans et al, 2002;MacManus and Hicks, 2003;Leong et al, 2006) and in the prediction of response (Di Fabio et al, 2005;Duong et al, 2006).…”

Pancreatic resection for metastatic melanoma

“…In patients with metastatic melanoma being considered for surgical intervention, PET scanning appears to be a particularly useful assessment tool [30]. PET has a higher sensitivity and speci®city than conventional imaging for detecting metastatic melanoma in all regions of body except the thorax [30,31]. In a study by Rinne and co-workers [31], PET was able to detect abdominal metastases in all known cases (25 of 25), compared with a 32% sensitivity (8 of 25) with conventional imaging.…”

“…PET has a higher sensitivity and speci®city than conventional imaging for detecting metastatic melanoma in all regions of body except the thorax [30,31]. In a study by Rinne and co-workers [31], PET was able to detect abdominal metastases in all known cases (25 of 25), compared with a 32% sensitivity (8 of 25) with conventional imaging. However, the sensitivity of PET is lower for tumours <1 cm, because of limitations of scanner resolution.…”