Primary stage I–IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients

Garavaglia, Elisabetta; Taccagni, Gianluca; Montoli, Serena; Panacci, N; Ponzoni, Maurilio; Frigerio, Luigi; Mangili, Giorgia

doi:10.1016/j.ygyno.2004.07.065

Cited by 45 publications

(35 citation statements)

References 13 publications

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“…Cervical lymphoma may present in a wide age range (20-80 years); however, 80 % of patients are premenopausal, and cervical lymphoma tends to occur in younger patients compared to other lymphomas [2,6,7]. The common presenting symptoms are abnormal vaginal bleeding (70 %), perineal discomfort (40 %), persistent vaginal discharge (20 %) and, less frequently, abdominal masses, dyspareunia, and urinary retention [2,3,6].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Non-Hodgkin’s Lymphoma of the Uterine Cervix: Case Report of Long-Term Survival Patient

Mouhajir

Diakité

Toulba

et al. 2013

J Obstet Gynecol India

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Section: Discussionmentioning

confidence: 99%

“…The common presenting symptoms are abnormal vaginal bleeding (70 %), perineal discomfort (40 %), persistent vaginal discharge (20 %) and, less frequently, abdominal masses, dyspareunia, and urinary retention [2,3,6].…”

Section: Discussionmentioning

confidence: 99%

Primary Non-Hodgkin’s Lymphoma of the Uterine Cervix: Case Report of Long-Term Survival Patient

Mouhajir

Diakité

Toulba

et al. 2013

J Obstet Gynecol India

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“…As primary sites of NHL, the uterus and cervix are very uncommon and account for 0.5% of extra-nodal lymphomas [3,4]. The majority of NHLs arising from the uterus and cervix are aggressive lymphomas of diffuse large B-cell NHL type (DLBCL) [5]. The presentation of uterine lymphoma is often subclinical; hence diagnosis can be difficult, especially in the differential diagnosis of common neoplasms such as fibroids or sarcomas [6].…”

Section: Introductionmentioning

confidence: 99%

Primary Non-Hodgkin’s Lymphomas of the Uterus and Uterine Cervix

Johannesson¹,

Mason²,

Miller³

et al. 2017

Oncology and cancer case reports

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confidence: 99%

“…Vaginal bleeding (70%), perineal discomfort (40%), and persistent vaginal discharge (20%) [1] are the most common clinical symptoms of primary malignant lymphoma of the uterine cervix, which is an extremely rare malignancy of the female genital tract occurring at a median of 40 years of age [2].…”

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confidence: 99%

Primary uterine lymphoma of the uterine cervix in advanced age

Naki¹,

Çelik²,

Api³

et al. 2010

Turk J Hematol

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Vaginal bleeding (70%), perineal discomfort (40%), and persistent vaginal discharge (20%) [1] are the most common clinical symptoms of primary malignant lymphoma of the uterine cervix, which is an extremely rare malignancy of the female genital tract occurring at a median of 40 years of age [2].An 82-year-old parous woman presented with persistent vaginal discharge for one year despite several antifungal and antibiotic combination regimens. Her past history and systemic examination were unremarkable. Papanicolaou smear revealed normal findings. Detection of a 15x15 mm nodular lesion in chest X-ray was confirmed to be a 35x30 mm lesion in the middle lobe and a 20 mm lesion in the lower part of the right lung with thoracic computerized tomography (CT). Serum lactate dehydrogenase (S-LDH) level was 402 U/ml. Colposcopically directed punch biopsies showed inflammation and necrosis while punch biopsy of the bladder revealed chronic cystitis. Inflammation was confirmed on repeated punch and fine needle aspiration biopsies (FNAB). Magnetic resonance imaging (MRI) scan showed a 52x40x45 mm cervical mass in the cervix uteri. Despite the lack of histological evidence, cervical malignancy was suspected based on clinical and radiological findings. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed together with intraoperative frozen section procedure. The operative finding was a hard mass that infiltrated the uterus and cervix with pelvic wall extension. Macroscopic examination of the hysterectomy specimen revealed a cervical mass measuring 50x40x15 mm and pathological examination showed non-Hodgkin's lymphoma (NHL) and diffuse large B cells positive for LCA and CD20 and negative for CD3 and cytokeratin (Figure 1). Lymph nodes and appendectomy specimens were negative for tumor metastasis. Bronchoscopic biopsy following thoracic CT revealed no sign of malignancy. The patient was classified as stage IE according to the Ann-Arbor classification and received three cycles of postsurgical chemotherapy with R-CHOP protocol. She remains under follow-up and is disease-free.Suspicion of cervical malignancy with respect to radiological findings in our case seems to be in accordance with past studies concerning the benefits of preoperative imaging studies in the diagnosis of cervical lymphomas [3,4]. Given that the patient was in stage IE with better prognosis [5] and was free of fertility-related surgical limitations, complete surgical resection followed by three cycles of chemotherapy according to R-CHOP protocol seemed to be quite effective in this case.In conclusion, while factors such as rarity of the disease, absence of specific gynecological as well as systemic symptoms and limited value of cervical smears are likely to complicate the diagnosis of primary uterine NHL, MRI findings seem to be directive in construction of a frozen section-based definitive diagnosis. Associated with good prognosis, complete surgical resection followed by chemotherapy according to R-CHOP protocol is beneficial in the man...

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Primary stage I–IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients

Cited by 45 publications

References 13 publications

Primary Non-Hodgkin’s Lymphoma of the Uterine Cervix: Case Report of Long-Term Survival Patient

Primary Non-Hodgkin’s Lymphoma of the Uterine Cervix: Case Report of Long-Term Survival Patient

Primary Non-Hodgkin’s Lymphomas of the Uterus and Uterine Cervix

Primary uterine lymphoma of the uterine cervix in advanced age

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