Primary Squamous Cell Carcinoma of the Thyroid Gland With Eggshell Calcification

Primary squamous cell carcinoma of thyroid gland with local recurrence: ultrasonographic and computed tomographic findings

“…Regarding US findings, PSCCT has been reported to be a nodule with eggshell calcification and peripheral soft tissue [8], or as a slowly growing, irregularly marginated hypoechoic solid nodule [9]. …”

“…When pathologic results reveal SCC of the thyroid gland, it is important to exclude metastases from other organs such as the thymus, lung, and other adjacent structures because metastatic SCC is more common than PSCCT [8]. PSCCT has a more fulminant course and poorer prognosis than metastatic SCC with a median survival of less than 6 months in the majority of cases.…”

Primary squamous cell carcinoma of the thyroid: Case report and systematic review of the literature

“…According to the inclusion/exclusion criteria, 52 full papers with reporting of 97 cases were screened. Some 17 publications with 48 cases without complete work-up, including CT-scan, panendoscopy, immunohistochemistry and double citations were excluded [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]. Finally, 35 papers and ours reporting on 50 patients were available for analysis [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58].

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Thyroid Nodules with Macrocalcification: Sonographic Findings Predictive of Malignancy

“…The results for thyroid nodules with macrocalcifications (larger than 1 mm at the longest diameter) are controversial. In macrocalcified thyroid nodules, peripheral rim or eggshell calcification has been considered associated with multinodular goiters and has been generally considered as an indicator of a benign nodule 19-21. There are a few reports suggesting that a considerable portion of the macrocalcified nodules are malignant.…”