Primary Squamous Cell Carcinoma of the Parotid Gland: The Importance of Correct Histological Diagnosis

Flynn, Michael B.; Maguire, Sean; Martinez, Serge A.; Tesmer, Timothy

doi:10.1007/s10434-999-0768-y

Cited by 60 publications

(57 citation statements)

References 8 publications

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“…7 The low index of Ki-67, the benign cytological morphology, and the clinical course of our patient confirm the benign nature of his keratocystoma. The lack of mucus cells and widespread keratinisation help to distinguish a keratocystoma from a mucoepidermoid carcimoma.…”

Section: Discussionsupporting

confidence: 73%

Keratocystoma of the parotid gland: a case report and review of previous publications

Wang

Tang

2015

British Journal of Oral and Maxillofacial Surgery

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Section: Discussionsupporting

confidence: 73%

Keratocystoma of the parotid gland: a case report and review of previous publications

Wang

Tang

2015

British Journal of Oral and Maxillofacial Surgery

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“…Data demonstrates the efficacy of postoperative RT in improving survival and local control for patients with carcinomas of the major salivary glands. The cause for treatment failure and death is most often metastatic disease as was the case with our patient [8,9]. The clinical stage at presentation has been noted to be a significant factor predicting survival whereas undifferentiated histology, male sex and skin invasion all contributed to poor outcome [7,8,10].…”

Section: Discussionmentioning

confidence: 57%

Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: A Rare Entity

Gaikwad

Kumaraswamy

Keerthi

2011

J. Maxillofac. Oral Surg.

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Salivary gland tumors make up about 3% of all neoplasms of the head and neck. Salivary gland tumors vary widely in histopathological appearance, thus it prompted the development of a revised histopathological classification of tumours. Malignant tumors can arise in the major salivary glands or numerous minor salivary glands lining the mucosa of the upper aerodigestive tract. This case highlights one of the rare variants of primary squamous carcinoma of the sub mandibular salivary gland and the management of submandibular salivary gland malignancies.

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“…Primary squamous cell carcinoma of the parotid gland is an aggressive malignancy with frequent facial nerve involvement or cervical metastases (12,13). Cystic changes are a wellknown finding in metaplastic nodal squamous cell carcinomas and are also noted in primary squamous cell carcinoma of the parotid gland (14).…”

Section: Discussionmentioning

confidence: 99%

Keratocystoma of the Parotid Gland: A Report of Two Cases of an Unusual Pathologic Entity

et al. 2002

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Benign salivary gland tumors composed of purely squamous cells are quite unusual and are not included in the World Health Organization classification. We have seen two benign parotid gland tumors characterized by multicystic spaces with stratified squamous linings and focal solid epithelial nests. Seifert et al. recently described such a case as a choristoma; we, however, herein propose a new designation, keratocystoma, for this unique tumor group, because of its distinctive histological features. These tumors occurred in men aged 18 and 38 years with enlarging parotid gland tumors. Both had largely similar gross and histological features, with some variations. The epithelium lining of the cysts showed apparent keratinization through a parakeratotic or orthokeratotic pathway without forming a granular cell layer. Stratification of the epithelium was always regularly oriented from the outer basal to the inner keratotic cell layer. Focally, the outer layer had bud-like protrusions. In some areas, solid squamous cell islands surrounded by basement membrane were enclosed within the collagenous stroma. These cystic and solid structures were randomly distributed, showing no definite lobular architecture. All of the tumor cells had uniform, bland nuclei and abundant eosinophilic cytoplasm. Scattered mitotic figures were observed, limited to the outer epithelial layer, and showed no abnormal patterns. Transformation from the parotid ductal epithelium to the tumor cells is evident.Foci of foreign-body reactions against keratin materials were present. Immunoreactivities for cytokeratins reconfirmed the nature of squamous differentiation of the tumor cells. Ki-67-positive cells were confined along the outer basal layer of the tumor epithelium. Tests for ␣-smooth muscle actin and S-100 protein were completely negative. Both patients had no evidence of recurrence 3 and 2 years after subtotal parotidectomy, respectively, without any additional therapy. We believe that this lesion represents a benign cystic neoplasm rather than a malignant tumor or pseudoneoplastic metaplastic condition. It is important to recognize that this peculiar benign tumor does originate from the salivary gland.

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Primary Squamous Cell Carcinoma of the Parotid Gland: The Importance of Correct Histological Diagnosis

Cited by 60 publications

References 8 publications

Keratocystoma of the parotid gland: a case report and review of previous publications

Keratocystoma of the parotid gland: a case report and review of previous publications

Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: A Rare Entity

Keratocystoma of the Parotid Gland: A Report of Two Cases of an Unusual Pathologic Entity

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