Primary squamous cell carcinoma of the parotid gland: clinicopathological characteristics, treatment, and prognosis

Xiao, Meng; Liu, J.; You, Yunxiang; Yang, Xi; Wang, Y.

doi:10.1016/j.ijom.2020.06.010

Cited by 10 publications

(32 citation statements)

References 17 publications

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“…Clinically, it is well known that parotid SCC was most common in males and old people (> 60 years). [ 2 , 3 , 6 ] In our series, 61.3% of our participants with primary parotid SCC were males with an average age of 61.5 years, similar to these reports. [ 2 , 3 , 6 ] Only age was an independent predictor for distinguishing the two histological groups, while the sex distribution was not different between the two malignancies.…”

Section: Discussionsupporting

confidence: 90%

“…[ 2 , 3 , 6 ] In our series, 61.3% of our participants with primary parotid SCC were males with an average age of 61.5 years, similar to these reports. [ 2 , 3 , 6 ] Only age was an independent predictor for distinguishing the two histological groups, while the sex distribution was not different between the two malignancies. Patients with primary parotid MEC in our series had an average age of 38.0 years, which is younger than some previous reports.…”

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

“…Primary parotid squamous cell carcinoma (SCC) is a rare entity with an incidence varying from 0.1 to 10% in salivary malignancies [ 1 – 3 ]. Primary parotid SCC usually conveys a poor prognosis even with surgery and postoperative radiotherapy [ 1 – 3 ]. At present, the pathological characteristics, therapy and prognosis of primary parotid SCCs have been well described [ 1 – 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Primary parotid SCC usually conveys a poor prognosis even with surgery and postoperative radiotherapy [ 1 – 3 ]. At present, the pathological characteristics, therapy and prognosis of primary parotid SCCs have been well described [ 1 – 3 ]. However, to date, only one literature has reported the MRI findings of primary parotid SCCs in a small sample size of just 7 patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma

Ban

et al. 2022

Insights Imaging

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Background Primary parotid squamous cell carcinoma (SCC) is a rare entity with a poor prognosis. Pathologically, the diagnosis of it requires the exclusion of parotid mucoepidermoid carcinoma (MEC). Currently, the imaging features of primary parotid SCC and the predictive indicators for differential diagnosis of the two entities have not been well reported. Our purpose was to identify the imaging characteristics of primary parotid SCC and to determine the predictive factors for its’ differential diagnosis. Results Thirty-one participants with primary parotid SCC and 59 with primary parotid MEC were enrolled. Clinical, CT and MRI features were reviewed and compared by univariate analysis. Then, multinomial logistic regression was used to determine the predictors to distinguish parotid SCC from MEC. Most primary parotid SCCs exhibited irregular shape, ill-defined margin, incomplete or no capsule, heterogeneous and marked or moderate enhancement, necrosis, local tumor invasiveness (LTI). Age, maximal dimension, shape, degree of enhancement, gradual enhancement, necrosis, and LTI were different between the primary parotid SCCs and MECs in univariate analysis (p < 0.05). While in multinomial logistic regression analysis, only age and necrosis were the independent predictors for distinguishing parotid SCC from MEC, and this model exhibited an area under curve of 0.914 in ROC curve analysis. Conclusions Primary parotid SCC has some distinct imaging features including the large tumor size, irregular shape, ill-defined margin, and particularly the marked central necrosis. Patients with age ≥ 51.5 years and necrosis on the image of the primary tumor in the parotid gland could be more likely to be SCCs than MECs.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma

Ban

et al. 2022

Insights Imaging

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Biopsy of the facial nerve in slow-onset facial palsy

Sistori,

Götting,

Radke

et al. 2024

Eur Arch Otorhinolaryngol

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Introduction Primary squamous cell carcinoma of the parotid gland typically presents as a palpable, often painless mass. Peripheral facial palsy as the only sign of malignant neoplasia is rare. In these cases, the diagnosis is regularly confirmed by radiological imaging followed by surgical exploration and biopsy. However, if there is no detection of malignant lesions and no evidence of a tumor, the reluctance to take a biopsy of an unremarkable nerve can lead to misdiagnoses. Case report A 40-year-old female patient without medical history presented to our clinic with a complete right-sided peripheral facial palsy that had slowly progressed for 2.5 years. All other otorhinolaryngological examination findings were within normal limits. Magnetic resonance imaging examination of the head and neck and 18-fluorodeoxyglucose positron emission tomography showed unremarkable results. We proceeded with surgical exploration, which revealed no evidence of a tumor and an externally completely unremarkable facial nerve. A biopsy from the main trunk area of the nerve revealed an infiltration by a squamous cell carcinoma. Total parotidectomy with resection and reconstruction of the facial nerve and neck dissection was performed. Considering the absence of a primary tumor and other tumor formations the diagnosis of a completely regressive primary squamous cell carcinoma of the parotid gland was confirmed. Conclusion In conclusion, in the case of slow-onset peripheral facial palsy that persists without signs of recovery, a gadolinium-enhanced MRI should be performed. If imaging is unremarkable and there is no primary tumor detection along the course of the facial nerve, a surgical exploration with biopsy of the facial nerve is necessary.

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Cancer-specific and overall survival of patients with primary and metastatic malignancies of the parotid gland - A retrospective study

Jering

Mayer

Thölken

et al. 2022

Journal of Cranio-Maxillofacial Surgery

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Primary squamous cell carcinoma of the parotid gland: clinicopathological characteristics, treatment, and prognosis

Cited by 10 publications

References 17 publications

Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma

Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma

Biopsy of the facial nerve in slow-onset facial palsy

Cancer-specific and overall survival of patients with primary and metastatic malignancies of the parotid gland - A retrospective study

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