Primary Squamous Cell Carcinoma of the Pancreas: A Report of Two Cases and Review of the Literature

Kridis, Wala Ben; Khanfir, Afef; Toumi, Nabil; Amar, Mohamed Ben; Boudawara, Tahia; Frikha, M.

doi:10.2169/internalmedicine.54.4091

Cited by 15 publications

(19 citation statements)

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“…Our study excluded mixed adenosquamous histological subtype resulting in a more homogeneous study population of patients diagnosed with pure squamous histology. In absence of population-based studies for SCC the evidence for SCC survival comes from case series reports 9,11,36-39 . The case series studies for patients with SCC reported median survival of 3 months 38 in patients treated with palliative intent and survival of 7 months 9 in patients who received potentially curative surgery.…”

Section: Discussionmentioning

confidence: 99%

“…The available published data on squamous subtype of pancreatic cancer is very limited, mostly presented as individual case reports or small case series studies. 5-11 As a result, the epidemiology and clinical course of pure squamous cell pancreatic carcinoma remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…In previous case series of patients with primary pancreatic malignancies squamous cell carcinoma denoted poor survival outcomes. 9,11 No comparison group was used in these analyses however, and, thus, more information is needed to determine whether squamous pancreatic cancer has a more aggressive clinical course compared to classical pancreatic adenocarcinoma (AC).…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic Squamous Cell Carcinoma

et al. 2016

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Objectives Squamous metaplasia is commonly detected in pancreatic parenchyma, however primary pancreatic squamous cell carcinoma (SCC) is a rare malignancy with unknown incidence and unclear prognosis. Methods Surveillance, Epidemiology, and End Results (SEER) registries were examined identifying pancreatic SCC and adenocarcinoma cases from 2000 to 2012. Age-adjusted incidence rates were calculated. Patients with SCC versus adenocarcinoma were compared by clinical features and relative survival outcomes. Results We identified 214 patients with SCC and 72,860 with adenocarcinoma. For SCC, incidence rates tripled between 2000 and 2012. Significantly higher SCC incidence rates were observed in older age groups, blacks and males. Greater proportion of patients with SCC than adenocarcinoma had poorly differentiated histology (73.0% versus 43.7%, p<0.001). In both subtypes, majority of patients had stage IV disease, 59.0% for adenocarcinoma versus 62.6% SCC. The 1-year and 2-year relative survival rate was significantly lower in patients with SCC versus adenocarcinoma. The 1-year relative survival was 14.0% (95% confidence interval (CI) =9.5-19.4) for SCC, compared with 24.5% (95%CI=24.2-24.8) for adenocarcinoma. Conclusions Although primary pancreatic SCC is a rare neoplasm, incidence rates for this subtype are increasing. Relative to adenocarcinoma, pancreatic SCC is characterized by poorly differentiated histology and worse survival.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pancreatic Squamous Cell Carcinoma

et al. 2016

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“…However, parenchymal squamous metaplasia is commonly detected in pancreatic specimens, and can be detected in 17% to 48% of cases [4]. Despite the relatively high frequency of squamous metaplasia, pancreatic squamous cell carcinoma (SCC) is a rare primary pancreatic malignancy, accounting for 0.05–5% of all pancreatic cancers approximately [4, 16–20]. In the present study, we screened 1033 cases of pancreatic cancer in Chinese population, and identified only 2 cases of pure SCC, accounting for only 0.19% of all cases.…”

Section: Discussionmentioning

confidence: 99%

“…By now, there are only twenty reported cases of pancreatic SCC (Table 7) [5, 14–16, 18, 19, 21, 24–35], providing limited, but valuable clinical information. The clinical presentation of SCC is similar to that of AC.…”

Section: Discussionmentioning

confidence: 99%

Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture

Liu

Feng

et al. 2017

Oncotarget

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Squamous cell carcinoma (SCC) of pancreas is a rare histotype of pancreatic ductal carcinoma which is distinct from pancreatic adenocarcinoma (AC). Although there are standard treatments for pancreatic AC, no precise therapies exist for pancreatic SCC. Here, we screened 1033 cases of pancreatic cancer and identified 2 cases of pure SCC, which were pathologically diagnosed on the basis of finding definite intercellular bridges and/or focal keratin peal formation in the tumor cells. Immunohistochemistry assay confirmed the positive expression of CK5/6 and p63 in pancreatic SCC. To verify the genomic characteristics of pancreatic SCC, we employed in-solution hybrid capture targeting 137 cancer-related genes accompanied by high throughput sequencing (HTS) to compare the different genetic variants in SCC and AC of pancreas. We compared the genetic alterations of known biomarkers of pancreatic adenocarcinoma in different pancreatic cancer tissues, and identified nine mutated genes in SCC of pancreas: C7orf70, DNHD1, KPRP, MDM4, MUC6, OR51Q1, PTPRD, TCF4, TET2, and nine genes (ABCB1, CSF1R, CYP2C18, FBXW7, ITPA, KIAA0748, SOD2, SULT1A2, ZNF142) that are mutated in pancreatic AC. This study may have taken one step forward on the discovery of potential biomarkers for the targeted treatment of SCC of the pancreas.

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The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer

et al. 2020

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Background The prognosis for nonmetastatic, primary pancreatic squamous cell carcinoma (SCC) is thought to be poor compared with adenocarcinoma (AC); however, this is based on limited data. Additionally, the optimal definitive treatment strategy for nonmetastatic pancreatic SCC is unknown. Methods We analyzed patients with nonmetastatic pancreatic cancer using the National Cancer Database for patients diagnosed from 2006 to 2014. Patients were analyzed according to histology—only AC, adenosquamous carcinoma (A‐SCC), and SCC were included. The primary endpoint was overall survival (OS) from the time of diagnosis. Results A total of 94 928 cases were included; 94 016 AC, 757 A‐SCC, and 155 SCC. Median OS was lower for SCC (8.67 months), compared to AC (13.93 months) and A‐SCC (12.71 months, P < .001). SCC was resected less often (25.5% vs 46.7% and 74.5%). On subgroup analysis of patients with pancreatic SCC, factors on multivariate analysis associated with improved survival included surgery (HR 0.19, P < .001), and chemotherapy (HR 0.22, P = .01). In 38 patients with SCC undergoing surgical resection, median OS improved (MS = 6.8 months without surgery vs 21.3 months with surgery, P < .001). Conclusions Nonmetastatic pancreatic SCC presents with more advanced disease, which is less often surgically resected or treated with any definitive local therapy. In contrast, AC and A‐SCC behave more similarly and have higher surgical resection rates and improved survival. In patients with nonmetastatic SCC of the pancreas, surgical resection provides the most significant survival benefit, with systemic chemotherapy providing a less significant benefit, and localized radiation providing no statistical benefit for any subgroup.

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Primary Squamous Cell Carcinoma of the Pancreas: A Report of Two Cases and Review of the Literature

Cited by 15 publications

References 10 publications

Pancreatic Squamous Cell Carcinoma

Pancreatic Squamous Cell Carcinoma

Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture

The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer

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