Primary squamous cell carcinoma of the stomach

Abstract

Abstract:Primary squamous cell carcinoma (SCC) of the stomach is extremely rare; only 32 cases are found in the Japanese literature. The pathogenesis of this neoplasm remains obscure and controversial. Furthermore, the optimal treatment, including adjuvant chemotherapy, remains unclear. We report herein a case of SCC of the stomach in a 70-year-old male with amazing effectiveness of neoadjuvant chemotherapy, low-dose FP chemotherapy. To our knowledge, no case of this disease has ever been reported that was given neoadjuvant chemotherapy and histologically showed its effectiveness. Our case demonstrated a striking effectiveness of chemotherapy in the neoplasm both radiologically and histologically.

Squamous cell carcinoma of the stomach

“…They included cases of adenosquamous carcinoma and diagnosis from a biopsy specimen only. Pure SCC of the stomach is a rare tumor, described in only 22 patients since 1905 in the English literature from all over the world [10][11], and in 31 cases in the Japanese literature [12]. The authors accept Dr. Adachi's comment that the pathogenesis of gastric SCC should be discussed thoroughly.…”

“…Although the authors believe their patient to be the 32nd case of gastric SCC in Japan, a search of the Japanese-language literature revealed additionally more than ten well-documented cases of primary SCC of the stomach [10][11][12][13]. Furthermore, three cases reported by Mori et al [2] must be included in the table of the Japanese cases.…”

Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: A case report

“…However, gastric SCC generally had a poor outcomes because of that is usually diagnosed at an advanced stage and aggressively metastasizes to the lymph nodes and the liver (1,7,8). Chemotherapy combined with surgical resection is reported to improve the prognosis (9). It is worth noting that no standard chemotherapy or chemotherapeutic regimen has been defined for SCC of the stomach till now.…”

Variants of Gastric Carcinoma: Morphologic and Theranostic Importance

“…There is no established standard adjuvant chemoradiation therapy for patients with primary squamous and adenosquamous carcinoma in the stomach. However, one isolated case suggested that low-dose 5-fluorouracil plus cisplatin would be an effective preoperative chemoregimen to shrink the size of tumors and lower postoperative complications [106].…”

“…The mean age of presentation is 64 years (range, 17 to 89 years) and men are affected about five times as often as women [104]. Patients with primary squamous or adenosquamous carcinoma of the stomach frequently present with advanced stage disease (pT3 or T4) with or without metastases or involvement of other organs (stage III or IV) [106]. It has known that these variants do not response well to the routine chemoregimen for conventional gastric carcinoma.…”