Primary squamous cell carcinoma of the breast: Case report and management decisions

Breast squamous cell carcinoma are rare, occurring in less than 0.1% of all breast carcinomas. This report describes the oncological conduct performed on a patient with a triple negative squamous cell carcinoma in the upper outer quadrant of the right breast. The same patient presented a lobular carcinoma in situ within a fibroadenoma of the contralateral breast, during the follow up period. The association of these two diseases in the same patient has not yet been described in the literature.

show abstract

“…Radiotherapy plays an important role, considering that most cases have a locally advanced presentation of the disease 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate that the prevalence of lymph node metastasis varies from 41% to 47% 7,17,18 . Patients with lymph node involvement from the neoplasm seem to have a better response to adjuvant chemotherapy compared to those with no involvement 18 .…”

Section: Discussionmentioning

confidence: 99%

Metachronous breast neoplasms: squamous cell carcinoma and lobular carcinoma in situ within a fibroadenoma

Moreno

Menegassi²,

Neto³

et al. 2020

Mastology

View full text Add to dashboard Cite

show abstract

“…SCCB is considered resistant to the standard chemotherapy regimens used for other breast cancers. Nevertheless, some studies found that adjuvant cisplatin-based regimens could be effective [ 6 , 7 , 21 , 22 ]. In addition, 62.1% to 85.7% of SCCB patients have overexpression of epidermal growth factor receptor (EGFR) [ 15 , 19 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of postoperative radiotherapy for squamous cell cancer of the breast in a surveillance epidemiology and end results population-based study

Sun

Liu

et al. 2016

Oncotarget

View full text Add to dashboard Cite

The therapeutic value of postoperative radiotherapy (RT) for squamous cell cancer of the breast (SCCB) is unclear. This retrospective study used a population-based national registry to determine the impact of postoperative RT on survival of women with SCCB. The Surveillance Epidemiology and End Results (SEER) database was used to identify females with SCCB who underwent primary surgical resection from 1973 to 2012. Kaplan–Meier survival analysis and Cox regression proportional hazard methods were used to determine the impact of RT following resection associated with cause-specific survival (CSS) and overall survival (OS). A total of 523 patients met the eligibility criteria. The median follow-up time was 55 months, the 10-year CSS and OS rates were 65.6%, and 46.0%, respectively. A total of 167 patients (31.9%) received postoperative RT. Multivariate analysis indicated that advanced pT and pN stage, and no postoperative RT were independently associated with poor OS; advanced pT and pN stage were independently associated with poor CSS. Postoperative RT was significantly associated with improved 10-year OS (54.5% vs. 42.0%, P =.001), but had no effect on CSS (P =.217). Analysis of patients with different stages of SCCB indicated that RT was associated with improved CSS (P =.047) and OS (P <.001) in those with stage II cancer and improved OS in patients with stage pN0 cancer (P <.001). Postoperative RT improved the survival of SCCB patients, especially in those with stage II and stage pN0 cancer.

show abstract

“…Because PSCCB is so rare, prognosis and optimal treatment are still controversial [1][2][3][4][5][7][8][9][10][11][12]. There is a small body of research regarding this topic which consists mainly of isolated case reports and a few larger case series.…”

Section: Discussionmentioning

confidence: 99%

“…Primary squamous cell cancer of the breast (PSCCB) is an extremely rare form of breast cancer with an incidence of approximately 0.04-0.1% of all breast cancers and more specifically 0.04-0.07% of all ductal carcinomas [1][2][3]5,[7][8][9][10][11][12]. PSCCB is a diagnosis of exclusion, with the following criteria that must be met: (1) tumor origin does not arise from overlying skin, nipple or adenexal components, (2) greater than 90% of the tumor must be composed of squamous cells, (3) no evidence of ductal or mesenchymal elements within the tissue sample, and (4) no other sites of primary squamous cell cancer are present [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Case Series and Literature Review of Primary Squamous Cell Cancer of the Breast

2014

J Surg

View full text Add to dashboard Cite

Background: Primary squamous cell carcinoma of the breast (PSCCB) is one of the rarest forms of breast cancer, accounting for less than 0.1% of all breast cancers. PSCCB can be aggressive with no typical radiologic findings on mammogram and a wide range of clinical presentations, often leading to delayed or missed diagnoses. Methods:We performed a retrospective review of patients diagnosed with PSCCB at our institution from 2007 to 2012. Inclusion criteria included females over the age of 18 years old with a primary tumor consisting of >90% malignant cells of squamous origin and excluded squamous cell cancer that had metastasized to the breast or lesions that were not independent of the overlying skin or nipple. In addition, we performed a literature review using the PubMed database.Results: We identified two patients diagnosed with PSCCB during that timeframe with ages ranging from 35-52 years old. The average size of the mass seen on mammogram was 2.1 cm (range of 1 cm to 3.6 cm). Histologically, all cancers were moderately to poorly differentiated with negative estrogen, progesterone, and HER2 receptor status and an elevated Ki-67. One patient underwent breast conservation with partial mastectomy and axillary sentinel lymph node biopsy with whole breast radiation. The second patient underwent a total mastectomy and axillary sentinel lymph node biopsy without radiation. Neither of the patients had evidence of regional nodal disease at time of surgery nor received any systemic therapy. Both patients were disease free at last follow up which was five to twenty eight months respectively. Conclusion:Because PSCCB is so rare, prognosis and optimal treatment are still controversial, making treatment options limited. More research is needed to further elucidate the biological behavior of this rare cancer as well prognostic factors that may allow more conservative treatment.

show abstract

Primary squamous cell carcinoma of the breast: Case report and management decisions

Cited by 14 publications

References 8 publications

Metachronous breast neoplasms: squamous cell carcinoma and lobular carcinoma in situ within a fibroadenoma

Metachronous breast neoplasms: squamous cell carcinoma and lobular carcinoma in situ within a fibroadenoma

Effect of postoperative radiotherapy for squamous cell cancer of the breast in a surveillance epidemiology and end results population-based study

A Retrospective Case Series and Literature Review of Primary Squamous Cell Cancer of the Breast

Contact Info

Product

Resources

About