Primary squamous cell carcinoma of the thyroid associated with papillary thyroid carcinoma and Hashimoto's thyroiditis

Kallel, Souha; Kallel, Rim; Ayadi, S.; Ghorbel, Abdelmonem

doi:10.1016/j.anorl.2018.05.012

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…Giuseppa G et al found that in a study of 305 cases of PTC divided into two groups, up to 40.2% of the patients coexisted both diffuse HT and PTC in one group, and the results of this study indicated that the coexistence of HT and PTC was very high (4). Several other studies have also shown that HT is closely related to PTC (2,5,21,22). Studies also suggested that HT might be an independent risk factor for thyroid cancer (23).…”

Section: Discussionsupporting

confidence: 56%

“…HT is the most common thyroid immune diseases. There is overwhelming evidence to show that HT is closely related to thyroid cancer, especially PCT (2)(3)(4)(5)(6)(7)(21)(22)(23). Giuseppa G et al found that in a study of 305 cases of PTC divided into two groups, up to 40.2% of the patients coexisted both diffuse HT and PTC in one group, and the results of this study indicated that the coexistence of HT and PTC was very high (4).…”

Section: Discussionmentioning

confidence: 54%

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On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

Huang

Ren

Zhu

et al. 2021

Preprint

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Background: Thyroid squamous cell carcinoma is very rare. At present, it is limited to case reports. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma(SCC) of the thyroid occurs is still a controversial issue. Hashimoto's thyroiditis(HT) is considered to be an independent risk factor for thyroid cancer, under the basis of HT, how tumor cells evolve and develop to papillary thyroid carcinoma(PTC), and particularly to de-differentiate into SCC is elusive.Patient: We report a 72-year-old female patient who developed multiple subtypes of PTC on a basis of HT, and finally to de-differentiate into SCC within the local foci of lymph node metastasis. Summary: We found that there was a variety of sub-types of PTC in this patient in the background of HT. SCC was found within local lymph node metastasis. Pathomorphology, immunohistochemistry, and molecular pathology have confirmed that SCC was derived from PTC, and then developed into poorly differentiated SCC and/or anaplastic carcinoma. We also conducted a comprehensive literature review.Conclusions: Thyroid SCC is derived from PTC and de-differentiated into poor differentiated SCC and/or anaplastic carcinoma, which is the result of the continuous evolution of PTC. It is suggested that the prognosis of the patient is very poor.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 54%

On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

Huang

Ren

Zhu

et al. 2021

Preprint

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“…The origin of ThySCC is not well understood. Some have suggested an 'embryonic-rest' theory of ThySCC development, whereby these cancerous cells develop from thyroglossal duct remnants, while another, more widely accepted theory, is that ThySCC results from squamous metaplastic transformation of other thyroid tumors [2][3][4][5]. The metaplastic theory is supported by the observation that approximately 40% of papillary thyroid cancers (PTC), along with many ATCs, contain regions of squamous metaplasia [6].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Characteristics of Primary Squamous Cell Carcinoma of the Thyroid: A National Cancer Database Analysis

et al. 2019

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Background Primary squamous cell carcinoma of the thyroid (ThySCC) is a rare cancer, primarily described only in case reports. We aimed to characterize the prognosis of ThySCC and compare its oncologic behavior to other thyroid malignancies. Methods The National Cancer Database was queried to identify patients with ThySCC, papillary, tall cell variant, poorly differentiated (PDTC), and anaplastic (ATC) subtypes of thyroid cancer treated from 2004 to 2015. Demographics, tumor characteristics, and treatments were compared by tumor type and assessed to identify independent predictors of overall survival (OS). Results Of 123,684 patients included, 314 had ThySCC. ThySCC patients had a 5-year OS of 17.7%, more closely resembling ATC (8.3%) than PDTC or PTC. ThySCC and ATC patients had similar demographics, except ThySCC patients who were younger (68.0 vs. 70.2 years, p \ 0.01). ThySCC tumors were smaller (mean 53.5 ± 45.7 vs. 69.5 ± 75.2 mm) with less frequent extrathyroidal extension (ETE) (64.0% vs. 73.8%), lymphovascular invasion (8.3% vs. 12.3%), and positive margins (22.0% vs. 28.3%) compared to ATCs (p \ 0.05). ETE [HR 3.1 (95% CI 1.5-6.4), p \ 0.05] and lymph node metastases [HR 2.2 (95% CI 1.2-4.0) p \ 0.05] were independently associated with worse OS for ThySCC patients. Both ThySCC and ATC patients had similar surgical success rates, with R1 resection possible in 37.3% versus 35.0% of patients, respectively (p \ 0.05). However, in contrast to ATC patients, adjuvant therapy was not associated with improved OS for ThySCC patients after complete resection. Conclusions ThySCC has a poor prognosis, similar to ATC, but with fewer aggressive features and no apparent survival benefit with adjuvant therapy after complete macroscopic surgical resection.

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“…In ltration of cervical lymph nodes may or may not be present. [5][6] Clinically anaplastic thyroid carcinoma is the main differential diagnosis. In our case histologically very evident squamous cell differentiation was seen, we could not detect any other component after cut up the whole specimen.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the thyroid -case report of a rare disease

Lévay

Kiss

Oberna

et al. 2023

Preprint

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Introduction Primary squamous cell carcinoma (SCC) of the thyroid gland is a very rare entity. The prognosis is very poor with a short survival time. The aim of this article is to report a case of a SCC of the thyroid gland in a 68-year-old woman, emphasizing how complicate is the operation and the adequate treatment of this disease. Case report A 68-year -old woman presented with rapidly growing neck mass with hoarseness and compressive symptoms. Physical examination revealed a hard fixed tumor with right sided vocal cord palsy. Histopathological result confirmed the diagnosis of SCC of the thyroid. PET/CT scan excluded the possibility of other primary malignancies. A surgical intervention was performed, however the patient died in the middle of the palliative radiation therapy. Conclusion SCC of the thyroid gland is a great challenge for the surgeon and also for the multidisciplinary team to come up with the best treatment option which is suitable for the patient due to its unfavorable prognosis.

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Primary squamous cell carcinoma of the thyroid associated with papillary thyroid carcinoma and Hashimoto's thyroiditis

Cited by 11 publications

References 7 publications

On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

Prognostic Characteristics of Primary Squamous Cell Carcinoma of the Thyroid: A National Cancer Database Analysis

Primary squamous cell carcinoma of the thyroid -case report of a rare disease

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