Primary Squamous Cell Carcinoma in the Testis: A Case Report

Abstract

A 51-yr-old man presented with an enlarged right testis for two months. The radically resected testis showed a relatively well-circumscribed ovoid mass, nearly replacing the normal architecture with central cystic changes. Microscopically, the mass was composed of ovoid shaped tumor cells of a moderately differentiated squamous cell carcinoma (SCC). The central portion of the mass was filled with well-formed laminated keratinous materials and the remnant cavity lined by dysplastic squamous epithelium, indicated SCC may be derived from an epidermal cyst. SCC is among the most common types of neoplasm afflicting human beings, but it is rare in the testis. To our knowledge, this is the second report of the testicular squamous cell carcinoma occurring in a patient without other primary tumors, and the firstly reported case in Korea.

Primary squamous cell carcinoma of the testis: a rare presentation

“…3 All case reports have shown similar histological findings with the presence of a cystic cavity containing keratin and the presence of a squamous cell lining. In all the case reports, the epidermoid cysts have transformed into squamous cell carcinomas 4 5…”

Squamous Cell Carcinoma Developing from a Testicular Epidermal Cyst: A Case Report and Literature Review

“…Most primary testicular tumors are germ cell tumors, and primary testicular SCCs are very rare, with only three cases reported in the English literature [2–5].…”

“…Up to now, three cases of primary SCCs of the testis have been reported in the English literature [3–5]. Bryan et al reported a case of a testicular tumor derived from the malignant transformation of an epidermal cyst [3].…”

“…Shih et al described a case involving testicular SCC that arose from the malignant transformation of a hydrocele [4]. Kim et al reported the case of a testicular tumor derived from the malignant transformation of an epidermal cyst [5].…”

“…However, as previously mentioned, epidermal cysts have the potential for malignant transformation. All SCC cases developing from epidermal cysts have been reported in patients over 50 years old [3, 5]. Therefore, there is the possibility that epidermal cysts in older patients may be complicated with neoplasm.…”