Primary Spindle Cell Sarcoma of the Breast

Çil, Timuçin; Altıntaş, Abdullah; Paşa, Semir; Işıkdoğan, Abdurrahman

doi:10.1159/000121469

Cited by 22 publications

(24 citation statements)

References 13 publications

(15 reference statements)

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“…Other types of pure sarcoma, such as spindle cell sarcoma, neuroectodermal tumor, angiosarcoma etc., have also been reported [5,6].…”

Section: Discussionmentioning

confidence: 80%

“…The pleomorphic and bizarre cellular features can suggest the diagnosis of metaplastic and pure sarcomas of the breast. The establishment of a diagnosis of sarcoma is generally difficult by FNA biopsy [5,6,8].…”

Section: Discussionmentioning

confidence: 99%

“…Chondrosarcoma in common locations is generally known as refractory to all types of conventional chemotherapy and radiotherapy. Surgery remains the only effective treatment [5,9]. Despite the satisfactory technical and esthetic results of the breastconserving surgery, the final diagnosis of chondrosarcoma and its resistance to radiotherapy forced us to perform a modified radical mastectomy.…”

Section: Discussionmentioning

confidence: 99%

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Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma

Gürleyik¹,

Yıldırım

Günal³

et al. 2009

Breast Care

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Background: Primary mesenchymal tumors are an extremely rare malignancy of the breast. Case Report: A 52-year-old woman presented with a rapidly growing breast mass. Physical examination established a large and round mass with regular margins in the upper-outer quadrant of the right breast. Ultrasound showed a hypoechoic solid mass (41 ×36 mm) with lobulated contours. Mammography revealed a hyperdense and relatively regular-shaped mass giving the impression of a benign tumor. However, a pathologic report of atypical cells after fine needle aspiration necessitated surgical excision. The mass was removed with a wide local excision. The tumor was diagnosed as a high-grade chondrosarcoma of the breast by histopathological analysis. Following the final diagnosis, we performed a modified radical mastectomy based on the knowledge that this malignancy is generally refractory to radiotherapy. The regional lymph nodes and local adjacent tissues were free of metastasis. The tumor was negative for estrogen and progesterone receptors as well as HER2. Conclusion: Chondrosarcoma tends to grow rapidly. Physical examination usually reveals a large, round mass. The tumor is regular-shaped, round, and complex echoic on mammography and ultrasound. It usually does not invade regional structures. Surgery remains the only effective treatment.

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“…Other types of pure sarcoma, such as spindle cell sarcoma, neuroectodermal tumor, angiosarcoma etc., have also been reported [5,6].…”

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma

Gürleyik¹,

Yıldırım

Günal³

et al. 2009

Breast Care

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“…Patients are classified as having RIS if they have a history of radiation exposure prior to the development of sarcoma in or near the treatment field, with histological confirmation of a sarcoma that is unique from the primary cancer. 2,3 In patients undergoing radiation for breast carcinoma, the current reported incidence of RIS is 0.07% at 5 years, 0.27% at 10 years, and 0.48% at 15 years. 4 The average latency for RIS is approximately 10 years.…”

Section: 2mentioning

confidence: 99%

Enlarging Breast Mass in a 55-Year-Old Woman

et al. 2014

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A 55-year-old woman presented to the clinic with a mass in her left breast that had been enlarging over the previous 3 months. The patient denied any antecedent trauma or infection. Her medical history was significant for hypertension and left breast invasive ductal carcinoma in 2007 treated with lumpectomy and adjuvant radiation as well as synchronous rectal cancer after neoadjuvant chemoradiation and abdominoperineal resection. As part of her treatment course, the patient received a total dose of 50.5 Gy pelvic irradiation and 60 Gy irradiation to the left breast and axillary basin. The patient was followed up with yearly computed tomography of the abdomen and pelvis in addition to yearly digital mammography. Her last mammogram, 5 months prior to presentation, was unremarkable. On physical examination, she had a hard, well-circumscribed, fixed mass in the upper, outer quadrant of her left breast. The lesion was not tender to palpation nor was there any associated axillary or supraclavicular lymphadenopathy. Examination of the nipple as well as the contralateral breast and axilla was unremarkable. Computed tomography of the thorax revealed a 6.7 × 4 cm mass arising from the left chest wall distinct from the left breast with extent to the pleural surface of the left thorax (Figure, A). Positron emission tomography revealed metabolic activity within the mass but did not reveal any distant disease. Core needle biopsy confirmed the diagnosis and the patient was offered resection with reconstruction.The patient underwent a left radical mastectomy including resection of the pectoralis major and minor and resection of the adjacent chest wall resulting in a chest wall defect spanning ribs 2 through 4 (Figure, B). The patient underwent immediate reconstruction of the chest wall with 2-mm-thick expanded polytetrafluoroethylene and latissimus dorsi pedicle flap reconstruction of the soft tissue defect and breast mound. A B Figure.A, Computed tomographic axial section of the thorax illustrating a left chest wall mass measuring 6.7 × 4 cm apparently distinct from the left breast parenchyma with possible pleural invasion. B, Postresection wound including chest wall. Lung parenchyma adjacent to the chest wall reveals stippling and fibrosis consistent with previous irradiation.

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“…Breast tumors are predominantly of epithelial origin, and non-epithelial tumors arising from indigenous structures in the breast are rare [1]. Primary pure breast sarcoma is a rare disease and constitutes 0.2% -1.0% of all mammary malignancies [2]. The exact etiology is still unknown but these tumors frequently occur in patients suffering with neurofibromatosis Type I [ NF 1].…”

Section: Introductionmentioning

confidence: 99%

Primary Malignant Peripheral Nerve Sheath Tumor of the Breast—A Case Report

Chalkoo¹,

Ahangar²,

Laharwal³

et al. 2011

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Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma. Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer. We report such a lesion in a 60-year-old female who presented with hard and painless breast lump for 2 years. Histopathology revealed a malignant spindle cell tumor of low grade potential. It was subsequently confirmed to be malignant peripheral nerve sheath tumor (MPNST) on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.

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Primary Spindle Cell Sarcoma of the Breast

Cited by 22 publications

References 13 publications

Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma

Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma

Enlarging Breast Mass in a 55-Year-Old Woman

Primary Malignant Peripheral Nerve Sheath Tumor of the Breast—A Case Report

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