Primary spinal epidural lymphoma: Patients’ profile, outcome, and prognostic factors: A multicenter Rare Cancer Network study

“…The site is at the thoracic spinal cord level in 75% of cases [2], which is thought to be due to the thoracic spinal cord being longer than the cervical and lumbar spinal cord, and the presence of abundant venous plexus [3]. Regarding symptoms, lumbar backache precedes diagnosis and persists for several months to about one year and neurologic manifestation aggravate through a subacute course in several weeks [4].…”

Section: Discussionmentioning

confidence: 99%

A Patient with Malignant Spinal Epidural Lymphoma with Initial Rapidly Aggravating Paraplegia

Go¹,

Iida²,

Aoki³

et al. 2017

OJO

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We report the case of a 51-year-old female with rapid neurological deterioration as an initial presentation of non-Hodgkin's lymphoma. Paraplegia occurred suddenly after a 4-day history of weakness and numbness of the lower extremity. MRI revealed a dorsal epidural mass from T10 to T11 that compressed the spinal cord. There was neither bone destruction nor a paravertebral mass. Emergency decompressive laminectomy and tumor resection were performed. Histological analysis of the surgical specimen indicated diffuse large B cell lymphoma. The clinical stage was IV on CT and complete remission was achieved by subsequent chemotherapy. Spinal cord compression occurs in the course of non-Hodgkin's lymphoma in 0.1% -6.5% of cases, but this situation usually develops in the late phase with bone destruction and/or a paravertebral mass. Cord compression and especially the severe symptoms such as paraplegia are rare as the initial presentation of lymphoma.

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“…However, in this clinical situation, case reports showed relapse or transformation after irradiationmonotherapy [2,19].Monnardetal.describe52consecu-tiveptswithprimaryspinalepidurallymphomatreatedmultiinstitutionally.Amultivariateanalysisshowedthatcombined modalitytreatment,besideothers,isafactorforafavorable…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…Myelopathy due to epidural spinal cord compression frequentlyoccursinpatients(pts)withmalignantdiseases.However, in pts with malignant lymphoma this complication is rare; less than 5% of pts with non-Hodgkin's lymphoma (NHL)showepiduralinvolvement [1][2][3][4][5][6][7].Furthermore,most oftheseptsarediagnosedwithhigh-gradelymphomawhereas an epidural growth of low-grade lymphoma is even more unusual. It has been estimated that central nervous system …”

Section: Introductionmentioning

confidence: 99%

Multimodal Therapy for Localized Spinal Epidural Follicular Lymphoma

Kahl

Hirt²,

Decker³

et al. 2010

Onkologie

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Background: Myelopathy due to epidural spinal cord compression is rare in patients with malignant lymphoma and most of these patients are diagnosed with high-grade lymphoma. An epidural growth of low-grade lymphoma is even more unusual. Due to this low incidence, therapeutic experience for this entity is limited. Patients and Methods: We report the outcome of 3 consecutive patients with primary spinal epidural follicular lymphoma (FL). Due to the clinical disorders of the patients and despite the localized disease, we used an intensive multimodal therapy concept consisting of spinal decompression, systemic (immuno)chemotherapy and local irradiation. All patients improved in their medical condition; 2 achieved a complete remission, 1 of these with long-term remission. Conclusions: In contrast to the established irradiation therapy for early-stage FL, an intensive multimodal therapy concept should be initiated in patients with primary spinal epidural FL. With this approach, a fast improvement of the symptoms and long-term disease-free survival is possible.

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Primary spinal epidural lymphoma: Patients’ profile, outcome, and prognostic factors: A multicenter Rare Cancer Network study

Abstract: Primary spinal epidural lymphoma has distinct clinical features and outcome, with a relatively good prognosis. After therapy, local control is excellent and systemic relapse occurs in less than half the cases. Combined modality treatment appears to be superior to RT alone.

Cited by 69 publications

References 24 publications

Primary Spinal Epidural B-Lymphoblastic Lymphoma

Primary Spinal Epidural B-Lymphoblastic Lymphoma

A Patient with Malignant Spinal Epidural Lymphoma with Initial Rapidly Aggravating Paraplegia

Multimodal Therapy for Localized Spinal Epidural Follicular Lymphoma

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