Primary Spinal Cord Melanoma

Kim, Min Soo; Yoon, Doe Hyun; Shin, Dong Ah

doi:10.3340/jkns.2010.48.2.157

Cited by 43 publications

(64 citation statements)

References 18 publications

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“…Previous report demonstrated the classification of spinal melanoma according to the shape and differentiation status of the cells, and indicated a favorable outcome of pure spindle cell type spinal melanoma. 4) However, our case had an obviously different histological subtype (may be mixed type). Therefore, further investigation is necessary to conclude whether the histological subtype indicates the prognosis.…”

Section: Discussionmentioning

confidence: 66%

“…5,8),13) A previous report stated that the presence of the blood brain barrier in the spinal cord prevents hematogenous spread and hampers the process of metastasis. 4) Considering the slow progression primary spinal malignant melanoma, it is critical to establish a precise diagnosis, because patients should undergo tumor removal to slow down the onset of neurological deficits, even in the case of central nervous system dissemination. MRI is the method of choice for the diagnosis of spinal tumors, including spinal malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of primary spinal malignant melanoma seems to be better than that of cutaneous melanoma, which is fatal within 6 months in patients with systemic involvement. 4,8) The mean survival time of patients with primary spinal malignant melanoma is approximately 6 years after symptom onset. 5,8) These facts indicate that surgical excision and postoperative adjuvant therapy, such as radiotherapy and chemotherapy, should be used for slowing the onset of neurological deficits, even in cases with central nervous system dissemination.…”

Section: Introductionmentioning

confidence: 99%

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Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

Kawanabe¹,

Ueda²,

Sasaki³

et al. 2014

NMC Case Report Journal

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The present case illustrates the incidental detection of a primary malignant melanoma of the thoracic spinal cord before central nervous system dissemination. A 54-year-old female fell down and bruised the thoracolumbar region. The patient visited a local doctor and underwent magnetic resonance imaging (MRI) of the thoracic and lumbar spine to rule out vertebral fractures. MRI revealed no vertebral fracture, but an intradural extramedullary mass was observed at the T12 level. She was referred to our hospital in October 2008. MRI showed that the mass appeared hyperintense on T1-weighted images and hypointense on T2-weighted images. T1-weighted MRI with gadolinium showed a mild homogeneous enhancement of the lesion. The patient underwent laminectomy at T11–L1, along with the complete removal of the tumor, and she exhibited no remarkable symptoms after surgery. Histopathological examination confirmed the diagnosis of malignant melanoma. Malignant melanoma was not detected elsewhere in the body. Neither radiotherapy nor chemotherapy was performed after surgery. Her neurological examination was unremarkable 5 years after the surgery and no tumor recurrence was detected. The present case suggests that patients with primary spinal malignant melanoma may survive >5 years without recurrence after complete surgical removal of the tumor alone. Complete removal of the tumor before central nervous system dissemination may be critical for treatment in such cases. Precise diagnosis via MRI may increase the detection of primary spinal malignant melanoma before central nervous system dissemination, thus facilitating prompt surgical removal, improving the prognosis of patients.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

Kawanabe¹,

Ueda²,

Sasaki³

et al. 2014

NMC Case Report Journal

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“…8,11 Signs and symptoms of this tumor were nonspecific and dependent on location. 12 However, literature concerning the symptomatic bilateral papilledema induced by increased intracranial pressure 13 or the presence of subarachnoid hemorrhage-like symptoms have been reported, and thus clinicians should be aware of these rare presentations. 14 PSM of extramedullary origin show typical changes on MRI.…”

Section: Discussionmentioning

confidence: 99%

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

et al. 2015

Spinal Cord Ser Cases

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STUDY DESIGN: A review of the literature and three case reports. OBJECTIVES: Primary spinal melanoma (PSM) of extramedullary origin is a rare malignant condition with limited current literature in regards to its clinical course, magnetic resonance imaging (MRI) findings, treatment strategies and prognosis. We reported here three cases of PSM of extramedullary origin. SETTING: China, Guangzhou. METHODS: We report three cases of PSM of extramedullary origin. The clinical and radiological findings of these cases were retrospectively analyzed. RESULTS: The three cases were all of males aged 39, 47 and 76 years, respectively. The duration of their symptoms was 3 weeks, 2 months and 11 months respectively. The extramedullary tumors were all well-defined solitary tumors and were located at C4-5, L2-3 and T9-10, respectively. In one case, involvement of the intervertebral foramen was found. Preoperative MRI showed hyperintense T1W signals and hypointense T2W signals in all three cases and all tumors were clinically misdiagnosed as schwannomas. The patients received total or subtotal resection surgery without radiotherapy or chemotherapy. Patients were alive at 18 months, 27 months and 36 months postoperative follow-up, respectively. CONCLUSION: PSM of extramedullary origin is a rare malignant tumor that shows characteristic findings on MRI. Surgical resection is the preferred treatment strategy.

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“…These cells are found underneath the brain and the brainstem, inside the ventricles, at the optic chiasm, in the grooves of the various lobes, in the substantia nigra and in the choroid16). Primary spinal cord melanoma is rare, but has been reported previously 9).…”

Section: Discussionmentioning

confidence: 98%

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Hirota

Yoshimura

Kubo

et al. 2017

J Korean Neurosurg Soc

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We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases. She died at 13 months after surgery. Although extracranial metastases of PIMM are extremely rare, we should carefully follow up extracranial metastases together with intracranial ones, especially by FDG-PET/CT, even at an early asymptomatic stage.

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Primary Spinal Cord Melanoma

Cited by 43 publications

References 18 publications

Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

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