Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study

Milano, Michael T.; Johnson, Mahlon D.; Sul, Joohee; Mohile, Nimish; Korones, David N.; Okunieff, Paul; Walter, Kevin A.

doi:10.1007/s11060-009-0054-7

Cited by 129 publications

(96 citation statements)

References 44 publications

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“…1,2,7 In a large population-based study from the Surveillance, Epidemiology, End Results database older age rather than younger age was associated with a poorer prognosis. 8 Recent investigations have begun to develop pathologic and immunohistochemical markers of prognosis. A study has shown increased mitotic index, increased cellularity, presence of Ki-67, and presence of cyclin D1 as independent markers of mortality in ependymomas.…”

Section: Discussionmentioning

confidence: 99%

Spinal Drop Metastasis in Myxopapillary Ependymoma: A Case Report and a Review of Treatment Options

et al. 2014

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Myxopapillary ependymoma (MPE) is a World Health Organization grade I ependymoma that is quite rare and generally thought to be benign. Possible drop metastasis from MPE has been reported three times in the literature; in each case there were cotemporaneous additional MPE lesions. We report the case of a man who had a piecemeal gross total resection of a MPE at L1-L3 followed by adjuvant external beam radiotherapy (EBRT) who presented sixteen months later with a lesion in the thecal sac consistent with drop metastasis. A subtotal resection and adjuvant EBRT were performed. The patient has been disease-free in follow-up 27 months from the second surgery. A review of the literature regarding the treatment for MPE showed that gross total resection is optimal initial management. Several retrospective studies supported the role of adjuvant radiotherapy in enhancing local control and progression-free survival. Chemotherapy has a minimal role in the management of MPE.

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Section: Discussionmentioning

confidence: 99%

Spinal Drop Metastasis in Myxopapillary Ependymoma: A Case Report and a Review of Treatment Options

et al. 2014

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“…Despite many advances in medical and surgical therapy in recent years, glioma remains a fatal disease, with overall poor survival [5]. Moreover, radiotherapy treatment for spinal cord glioma is associated with worsened outcomes [6]. Interestingly, one study provides new insight for understanding the function of the long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1) in cancer biology, with the potential of TUG1 overexpression in glioma therapy [7].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway

Han

Wen

et al. 2018

Cell Physiol Biochem

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Background/Aims: Spinal cord glioma is a highly aggressive malignancy that commonly results in high mortality due to metastasis, high recurrence and limited treatment regimens. This study aims to elucidate the effects of long non-coding RNA LINC01260 (LINC01260) on the proliferation, migration and invasion of spinal cord glioma cells by targeting Caspase recruitment domain family, member 11 (CARD11) via nuclear factor kappa B (NF-κB) signaling. Methods: The Multi Experiment Matrix (MEM) website was used for target gene prediction, and the DAVID database was used for analysis of the relationship between CARD11 and the NF-κB pathway. In total, 60 cases of glioma tissues and adjacent normal tissues were collected. Human U251 glioma cells were grouped into blank, negative control (NC), LINC01260 vector, CARD11 vector, siRNA-LINC01260, siRNA-CARD11, LINC01260 vector + CARD11 vector and LINC01260 + siRNA-CARD11 groups. A dual-luciferase reporter assay was conducted to verify the target relationship between LINC01260 and CARD11. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were employed to assess expression of LINC01260, E-cadherin, p53, CARD11, Ki67, N-cadherin, matrix metalloproteinase (MMP)-9, NF-κBp65 and NF-κBp50. MTT, flow cytometry, wound-healing and Transwell assays were performed to examine cell viability, the cell cycle, apoptosis, invasion and migration. Tumor growth was assessed through xenografts in nude mice. Results: CARD11 was confirmed to be a target gene of LINC01260 and was found to be involved in regulating the NF-κB pathway. Compared with adjacent normal tissues, glioma tissues showed reduced expression of LINC01260 and elevated expression of CARD11 and genes related to apoptosis, invasion and migration; activation of NF-κB signaling was also observed. In contrast to the blank and NC groups, an elevated number of cells arrested in G1 phase, increased apoptosis and reduced cell proliferation, invasion and number of cells arrested in S and G2 phases, as well as tumor growth were found for the LINC01260 vector and siRNA-CARD11 groups. Conclusions: Our findings demonstrate that overexpression of LINC01260 inhibits spinal cord glioma cell proliferation, migration and invasion by targeting CARD11 via NF-κB signaling suppression.

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“…7,42,62 Maximal resection is generally agreed to be the cornerstone of treatment for pediatric spinal ependymomas; 2,7,8,34,42,47,50 however, the addition of adjuvant radiation therapy after surgery is the subject of more debate. 2,7,8,48 While there are many studies on spinal ependymomas in adults, 11,12,[16][17][18]21,24,25,38,41,45,51,56,57,61,65 there are few papers on these tumors in children, and those that do exist tend to be small, single-institution retrospective studies that are not powered for statistical analysis stratified by tumor grade. 2,8,13,22,27,42,47,53 The goal of this paper is to use the nationally representative Surveillance Epidemiology and End Results (SEER) database to offer a population-based perspective on pediatric Grade II spinal ependymomas.…”

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confidence: 99%

Treatment of pediatric Grade II spinal ependymomas: a population-based study

Lin

Jea

Melkonian

et al. 2015

PED

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OBJECT Grade II spinal cord ependymomas occurring in pediatric patients are exceptionally rare neoplasms. In this paper the authors use a national cancer database to determine patient demographics, treatment patterns, and associated outcomes of this cohort. METHODS The Surveillance Epidemiology and End Results (SEER) database was used to analyze subjects younger than 18 years with histologically confirmed diagnoses of Grade II spinal cord ependymoma from the years 1973 to 2008. Descriptive data on the demographic characteristics of this cohort and the associated treatment patterns are shown. The Kaplan-Meier method was used to estimate overall survival at 1, 2, 5, and 10 years. RESULTS This cohort comprised 64 pediatric subjects with Grade II spinal ependymoma. The median age was 13 years, nearly half of the patients were male, and most were white (84%). The median follow-up was 9.2 years. Overall survival at 5 and 10 years was 86% and 83%, respectively. Gross-total resection was achieved in 57% of subjects, and radiation therapy was administered to 36%. Radiation therapy was administered to 78% of subjects after subtotal resection but only to 19% of patients after gross-total resection; this difference was significant (p < 0.001). In a multivariate regression model analyzing sex, age at diagnosis, year of diagnosis, radiotherapy, and extent of resection, female sex was found to be an independent predictor of decreased mortality (HR 0.15 [95% CI 0.02–0.94], p = 0.04). CONCLUSIONS These data show long-term outcomes for pediatric patients with Grade II spinal ependymoma. Radiotherapy was more likely to be administered in cases of subtotal resection than in cases of gross-total resection. Female sex is associated with decreased mortality, while other demographic or treatment modalities are not.

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Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study

Cited by 129 publications

References 44 publications

Spinal Drop Metastasis in Myxopapillary Ependymoma: A Case Report and a Review of Treatment Options

Spinal Drop Metastasis in Myxopapillary Ependymoma: A Case Report and a Review of Treatment Options

Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway

Treatment of pediatric Grade II spinal ependymomas: a population-based study

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