Primary solitary fibrous tumor of kidney: A case report and literature review

Abstract

Primary solitary fibrous tumors of kidney are rare in clinical practice. In literature, only eleven reported cases originated from renal pelvis. We report a case of a 45 year old middle-aged woman who was the first report that a small number of heterosexual cells have been found in urine. Definite diagnosis of this disease still depends on pathological examination, If preoperative puncture or other pathological examination supports the diagnosis of SFTs, the preferred treatment plan for it is surgical resection.

Solitary fibrous tumor of the renal pelvis: A case report

“…Most of the SFTs are benign lesions with slow progress, but some have malignant potential[ 4 ]. Renal pelvis SFT is an extremely rare entity, with only 11 cases reported in the published literature[ 5 ]. Renal pelvis SFT is liable to be misdiagnosed as renal cell carcinoma (RCC), upper-tract urothelial cancers (UTUCs) or renal angiomyolipoma (RAML).…”

Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma

“…Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare tumors that derive from mesenchyme. SFT and HPC were formerly considered to be different diseases, however closely related due to similarities observed in immunohistochemical positive staining in CD34, CD99, vimentin, BCL2, and epithelial membrane antigen (1)(2)(3)(4)(5). This lack of specificity in SFT/HPC occasionally caused problems in differentiating them from other tumors that are immunohistologically alike them.…”

“…In 2013, three groups reported that SFT and HPC have a common gene fusion between NGFI-A-binding protein 2 (NAB2) and signal transducer and activator of transcription 6 (STAT6) (1,6,7). Thereafter, STAT6, which has dual functions as a signal transducer and as transcription activator in SFT and HPC, was recognized as the highly sensitive and specific immunohistochemical marker for SFT/HPC (2)(3)(4)(5)(8)(9)(10)(11).…”