Primary Small Intestinal Malignancy - A Clinic O - Pathological Stud Y, Its Comparis I on With Primary Gastrointestinal Malignancy and Earlier Studies

Abstract

OBJECTIVES:The aim of the study is to determine the clinico-pathological features of primary small intestinal malignant tumors and to compare with primary gastrointestinal malignancies and previous studies. MATERIALS AND METHODS: 11 patients with primary small intestine malignant tumors diagnosed over a 5 year period were studied clinically and histopathologically, they were classified using the WHO classification and compared with 300 primary gastrointestinal tumors and the previous studies. RESULTS: 11 patients (3.6%) were small intestine malignancies arising out of 300 primary gastrointestinal malignancies, with a male to female ratio of 1:1.2. Majority were females, majority were non vegetarians and most of the males were alcoholics and smokers. The youngest patient affected is 34 years old and the oldest patient is 67 years old with mean age of 52.17 and median age of 53 years. Tumor more common in the fifth to seventh decade of life. Altered bowel habits, abdominal discomfort was the most common clinical presentations followed by abdominal pain and vomiting in few cases. Duodenum was commonest site (72.2%) and few cases with equal proportion occurred in jejunum and ileum (9.09%). The commonest gross presentation was polypoidal growth (63.6%) and the rest of the tumors were ulcerative type. Adenocarcinoma was the most common histological type (81.8%) and 9% were Carcinoid and Gastrointestinal stromal tumor. CONCLUSION: Primary small intestinal malignancy constitute about 3.6% of allgastrointestinal malignancies, females commonly affected (1:1.2) and more common in alcoholics and non-vegetarians. Altered bowel habits, abdominal discomfort was the most common clinical presentations, Duodenum was commonest site (72.2%), The commonest gross presentation was polypoidal growth (63.6%), Adenocarcinoma was the most common histological type (81.8%)