Primary Small Cell Neuroendocrine Tumour of Gallbladder Presenting as Pyrexia of Unknown Origin

Dhali, Arkadeep; Ray, Sukanta; Dhali, Gopal Krishna

doi:10.7759/cureus.15874

Cited by 3 publications

(6 citation statements)

References 16 publications

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“…Immunohistochemical staining is crucial for confirming neuroendocrine differentiation, with common markers including synaptophysin, chromogranin A, and CD56. A high Ki-67 index is indicative of the aggressive nature of small cell NEC [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…They are most commonly seen in the gastrointestinal and respiratory systems. The gallbladder is a very rare localization for neuroendocrine tumors and its prevalence has been reported to be only 0.21% of all gastrointestinal carcinoids [ 1 , 2 ]. Small cell neuroendocrine tumors of the gallbladder are highly aggressive tumors with low survival rates and the literature is limited to a small number of cases.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of small cell neuroendocrine carcinoma of gallbladder origin

Dülger,

Erdem,

Cünük

et al. 2024

Journal of Surgical Case Reports

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Neuroendocrine carcinomas (NECs) of the gallbladder are very rare and aggressive tumors with poor prognosis. Most of them are poorly differentiated and belong to the small cell type. We report a case of a 59-year-old woman who presented with abdominal pain and distension. Contrast-enhanced computed tomography revealed a large heterogeneous mass in the liver, adjacent to the gallbladder, and omental nodules. CA 19-9 level was elevated and ascitic fluid cytology was suspicious for malignancy. Percutaneous biopsy of the liver mass confirmed the diagnosis of small cell NEC of the gallbladder. The patient was considered inoperable and planned for chemotherapy, but she died 20 days after admission. This case illustrates the diagnostic challenges and the dismal outcome of small cell NEC of the gallbladder. Early detection and multimodal treatment are essential for improving the survival of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A rare case of small cell neuroendocrine carcinoma of gallbladder origin

Dülger,

Erdem,

Cünük

et al. 2024

Journal of Surgical Case Reports

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“…There are no symptoms specific to GB‐NENs. The most common symptom is right upper quadrant pain, which may be accompanied by nausea, vomiting, and a positive Murphy's sign 10,19–23 . Some patients also present with weight loss and anorexia 23 .…”

Section: Discussionmentioning

confidence: 99%

“…The most common symptom is right upper quadrant pain, which may be accompanied by nausea, vomiting, and a positive Murphy's sign. 10 , 19 , 20 , 21 , 22 , 23 Some patients also present with weight loss and anorexia. 23 There were no subjective symptoms or significant physical findings in this patient.…”

Section: Discussionmentioning

confidence: 99%

Effective treatment of gallbladder neuroendocrine carcinoma with nivolumab

Kanda,

Hiyama,

Kirino

et al. 2023

Clinical Case Reports

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“…Occasionally NETs are reported in the hepatobiliary system. The gallbladder is a rare site of occurrence and accounts for less than one percent of the malignancy [2,3].…”

Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma of Gallbladder With Nodal Metastasis Mimicking As Synchronous Malignancy in Gallbladder and Common Bile Duct

Naik¹,

Shaikh²,

Sowmiya³

et al. 2021

Cureus

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Small cell carcinoma of the gallbladder is an extremely rare disease. Even with current aggressive and diverse treatments, small cell carcinoma of the gallbladder has an extremely poor prognosis. The presence of synchronous malignancies in the gallbladder and the biliary tract is even rare. Synchronous malignancy can be due to either local spread or metastasis. It can also occur due to field change in the extrahepatic malignancy or can arise de novo as multifocal malignancy. Small cell carcinoma of gallbladder with nodal metastasis mimicking as synchronous malignancy in the gallbladder and distal common bile duct is rare. We report a 74-year-old male who presented with abdominal pain and jaundice. Initial imaging studies were suggestive of the possibility of synchronous malignancy in the gallbladder and common bile duct. However, further imaging studies showed that carcinoma of the gallbladder had metastasis to the lymph nodes, causing external compression to the common bile duct rather than synchronous malignancy. Cytology was diagnostic of small cell carcinoma of the gallbladder. The patient had metastasis to other sites also. The patient underwent endoscopic retrograde cholangiopancreatography with stenting and started on palliative platinum-based chemotherapy with cisplatin and gemcitabine, and he is under regular follow-up.

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Primary Small Cell Neuroendocrine Tumour of Gallbladder Presenting as Pyrexia of Unknown Origin

Cited by 3 publications

References 16 publications

A rare case of small cell neuroendocrine carcinoma of gallbladder origin

A rare case of small cell neuroendocrine carcinoma of gallbladder origin

Effective treatment of gallbladder neuroendocrine carcinoma with nivolumab

Small Cell Carcinoma of Gallbladder With Nodal Metastasis Mimicking As Synchronous Malignancy in Gallbladder and Common Bile Duct

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