Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases

Abstract

Background: Primary small cell carcinoma (SCC) of the esophagus is a rare and aggressive tumor with poor prognosis. In this study, we report the clinicopathological characteristics of 21 cases of small cell carcinoma of the esophagus treated at the Cancer Center of Sun Yat-Sen University, with particular focus on the histologic and immunohistochemical findings.

TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies

“…For this reason we used this cutoff value to discriminate between negative and positive tumors. However, it is worth noting that some authors considered tumors negative when no staining was observed [8,10,19,20,[33][34][35][36][37][38] while in other studies a cutoff of 5% was used to discriminate between negative and positive neoplasms [16,22]. Our study has demonstrated, in a large series of lung NE neoplasms, that the SPT24 antibody is more sensitive than the 8G7G3/1.…”

“…Agoff et al [7] 0/1 2/4 4/4 1/7 0/6 8G7G3/1 Barbareschi et al [41] 3/13 2/10 5/5 2/3 8G7G3/1 La Rosa et al [43] 0/1 8G7G3/1 Carlson et al [33] 3/8 8G7G3/1 Soriano et al [44] 2/10 8G7G3/1 Jones et al [45] 17/44 8G7G3/1 Yao et al [46] 15/18 8G7G3/1 Wang et al [47] 23/44 8G7G3/1 Yun et al [38] 15 Oliveira et al [10] 0/24 0/10 8/10 Lin et al [18] 0/10 0/1 2/2 Schmitt et al [21] 0/28 0/18 Present study 0/14 0/3 0/4 a Total (%) 0/76 0/32 10/16 (63) Findings obtained with the 8G7G3/1 antibody a When using the SPT24 antibody we found that one out four metastases was TTF1 positive Agoff et al [7] 0/48 0/15 Oliveira et al [10] 0/48 0/10 0/3 Cai et al [19] 1/46 a 0/12 Lin et al [18] 0/60 0/30 0/1 Schmitt et al [21] 1/63 b 1/87 Present study 0/60 0/26 Kaufman et al [15] In all studies the 8G7G3/1 antibody was employed a The positive case was located in the stomach b The positive case was located in the ileum c In these studies gastrointestinal and pancreatic well-differentiated NE tumors were considered together…”

Neuroendocrine carcinoma of the esophagus: clinical characteristics and prognostic evaluation of 49 cases with surgical resection

“…Lee et al (7) have reported only 7 cases (0.3%) of esophageal NEC in an analysis of 2,037 NENs arising in different gastrointestinal sites. Owing to its rarity, there has been no concrete data with large sample size published on its clinical features or prognosis (7)(8)(9). As a result, its clinicopathological characteristics and optimum treatment are far from being well established up to date.…”

A Complete Response in Small Cell Carcinoma of the Esophagus Treated by S-1/Cisplatin Combined Chemotherapy and Radiotherapy

“…The molecular characteristics that have been reported are the high proliferative activity, frequency of p53 overexpression, and telomerase activation [20][21][22]. The median survival time of SmCCE is reported to range from 11.7 to 18.3 months [2,3,9], and the 5-year survival rate is reported to range from 8.2% to 20% [3,4,7]. Therefore, SmCCE is considered to have a more malignant characteristic and behavior than SqCCE.…”