Primary small cell carcinoma of the kidney

Akkaya, Bahar; Usta, Mustafa; Özel, E; Köksal, Türker; Karpuzoğlu, Gülten

doi:10.1016/s1078-1439(03)00021-8

Cited by 18 publications

(6 citation statements)

References 10 publications

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“…The diagnosis of renal SCC is based on light microscopic criteria established for the diagnosis of pulmonary SCC. Ultrastructural and immunohistochemical studies may be required to differentiate renal SCC from lymphoma, carcinoid tumor, neuroblastoma, renin secreting tumors, primitive neuroectodermal tumor/Ewing sarcoma, and rhabdomyosarcoma [18]. A diagnostic algorithm is presented in Figure 2 to differentiate small cell carcinoma from similar appearing tumors.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature

et al. 2011

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Extrapulmonary small cell carcinoma occurs in nearly all organs except the central nervous system and the liver. We are presenting a case of renal small cell carcinoma (SCC) with two unique characters. A 75-year-old patient was evaluated for back pain with no other complaints. Magnetic Resonance (MR) imaging of the abdomen revealed homogeneous tumor in the left renal pelvis extending beyond the kidney. Metastatic workup was negative. A left nephroureterectomy was performed. Histopathology and immunohistochemistry revealed a small cell carcinoma of the renal pelvis. The patient declined adjuvant therapy and died 2 months after surgery due to unrelated causes. After comprehensive worldwide literature search, we found 13 cases of SCC of the renal pelvis, including the current case. The mean age was 61.6 years (37–83), with a M : F ratio of 1 : 1.8. The average duration of symptoms was 71.4 days (21–168). Gross hematuria was the most common symptom (69.2%) followed by pain (61.5%). Adjuvant chemotherapy was provided to 4 patients (30.7%), and neoadjuvant to 1 patient. The median survival of patients who did and did not receive chemotherapy was 5.5 months (3–8) and 6 months (2–31), respectively, P < .50. In conclusion, renal SCC (both parenchymal and pelvic SCC) is a rapidly fatal disease with a median survival of ≤8 months.

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Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature

et al. 2011

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“…Small-cell carcinoma accounts for 10% to 20% of all primary malignancies of the tracheobronchial tree [2,6]. Approximately 2.5% of all small-cell cancers occur in the extrapulmonary sites.…”

Section: Discussionmentioning

confidence: 99%

“…Less then 30 cases of primary small-cell carcinoma of the kidney (PSCCK) have been reported in the literature [1][2][3][4][5]; to our knowledge, this is the first description of the MRI findings in this entity.…”

Section: Introductionmentioning

confidence: 99%

MRI findings of primary small-cell carcinoma of kidney

Karadeniz-Bilgili

Semelka

Hyslop

et al. 2005

Magnetic Resonance Imaging

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“…Small cell neuroendocrine carcinoma of the kidney. Renal small cell neuroendocrine carcinomas (SCNEC) are rare, the approximate number of the reported cases is 50 (6,(20)(21)(22). These tumors resemble the small cell carcinoma of the lungs.…”

Section: Neuroendocrine Tumors Of the Kidneymentioning

confidence: 99%

“…The cut surface is soft, whitish, gritty, and necrotic with a solid growth. Infiltration of the renal sinus, renal vein, and perirenal tissue is frequent (21). Microscopically, the tumor consists of poorly differentiated small, round cells that compose sheets and nests.…”

Section: Neuroendocrine Tumors Of the Kidneymentioning

confidence: 99%