Primary small-bowel adult T-cell leukemia/lymphoma with gastric AL amyloidosis

Yaita, Hiroki; Nakamura, Shotaro; Kurahara, Koichi; Nagasue, Tomohiro; Kochi, Shuji; Oshiro, Yumi; Ohshima, Koichi; Ikeda, Yuichi; Fuchigami, Takeshi

doi:10.1055/s-0034-1390757

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Ishibashi et al reported that gastric, small intestinal, and large intestinal ATLL lesions were present in 66%, 18%, and 16% of cases, respectively [ 125 ]. ATLL of primary GI origin without leukemic changes or systemic lymphadenopathy has also been reported [ 126 , 127 , 128 , 129 , 130 ].…”

Section: Differential Diagnoses and Diagnostic Pitfallsmentioning

confidence: 99%

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

Nishimura

Nishikori

et al. 2021

Cancers

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Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their rarity. The two most common aggressive primary GI T-cell lymphomas are enteropathy-associated T-cell lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma. In addition, extranodal natural killer (NK)/T-cell lymphoma of the nasal type and anaplastic large cell lymphoma may also occur in the GI tract or involve it secondarily. In the revised 4th World Health Organization classification, indolent T-cell lymphoproliferative disorder of the GI tract has been incorporated as a provisional entity. In this review, we summarize up-to-date clinicopathological features of these disease entities, including the molecular characteristics of primary GI T-cell lymphomas and indolent lymphoproliferative disorders. We focus on the latest treatment approaches, which have not been summarized in existing reviews. Further, we provide a comprehensive review of available literature to address the following questions: How can pathologists discriminate subtypes with different clinical prognoses? How can primary GI neoplasms be distinguished from secondary involvement? How can these neoplasms be distinguished from non-specific inflammatory changes at an early stage?

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Section: Differential Diagnoses and Diagnostic Pitfallsmentioning

confidence: 99%

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

Nishimura

Nishikori

et al. 2021

Cancers

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Primary localized amyloidoma of the renal pelvis: A case report and literature review

et al. 2015

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Abstract. Primary localized amyloidomas of the renal pelvis are challenging to diagnose, due to non-specific imaging results and the unusual location. The present study reports a rare case of primary localized amyloidoma of the renal pelvis and aims to illustrate the challenges in pre-operatively discriminating between this disease and transitional cell carcinomas. The present study identified that the mass was situated in the left renal pelvis using ultrasonography. A nephroureterectomy was performed following careful preparation. Finally, histopathological studies revealed that the tumor consisted of massive diffuse deposits of amyloid and microscopic amorphous eosinophilic material, which stained positively for Congo red, demonstrating potassium permanganate digestion. Consequently, a diagnosis of amyloid light chain-type amyloidoma was determined. Systematic examinations were performed following the unexpected diagnosis, which eliminated the possibility of amyloid associated-type amyloidoma. In total, 4 months post-surgery, the patient remained tumor-free. IntroductionLocalized amyloidoma is generally divided into two styles: AL-type and AA-type. AL-type occurs with an immunocyte dyscrasia while AA-type occurs with chronic infection, non-immunocyte neoplasia or inflammation. Localized amyloidoma occurs most often in the mediastinum or abdomen. Although amyloidomas may occur in almost all organ systems in the body; however, primary amyloidoma of the renal pelvis is rare. Using the keywords: 'renal pelvis', 'amyloidoma' and 'amyloid tumor' and search terms (renal pelvis) and (amyloidoma or amyloid tumor) in PubMed (National Center for Biotechnology Information, U.S. National Library of Medicine, Bethesda, MD, USA), a literature search was performed and only 26 cases of primary amyloidomas of the renal pelvis were identified (Table I) (1-23). Primary localized amyloidoma may present as hematuria and lumbago (14). A primary localized amyloidoma of the renal pelvis consists of amyloid deposits that may present as malignant tumors (15). The present study reports the rare case of a patient with amyloidoma that was confined to the renal pelvis, and the patient exhibited similar symptoms to those of upper urinary tract transitional cell carcinoma (TCC). In addition, 26 cases of patients with primary amyloidoma of the renal pelvis identified from the literature were also reviewed. Nephrectomy was the most selected treatment in the reported cases. The majority of patients achieved long time disease free survival and good prognosis. (7). The clinical and pathological features of the cases were discussed, in particular, the treatment methods and prognosis. Case reportA 56-year-old man presented to the Department of Urology, Sun-Yat Sen University Cancer Center (Guangzhou, China) with left flank pain, symptoms of urinary irritation and intermittent gross hematuria. The patient had experienced the symptoms for 6 years; however, in the month prior to presentation, the Primary localized amyloidoma of the renal pelvis:A case ...

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Rare gastrointestinal lymphomas: The endoscopic investigation

Vetro

Bonanno

Giulietti

et al. 2015

WJGE

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Gastrointestinal lymphomas represent up to 10% of gastrointestinal malignancies and about one third of non-Hodgkin lymphomas. The most prominent histologies are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma. However, the gastrointestinal tract can be the site of rarer lymphoma subtypes as a primary or secondary localization. Due to their rarity and the multifaceted histology, an endoscopic classification has not been validated yet. This review aims to analyze the endoscopic presentation of rare gastrointestinal lymphomas from disease diagnosis to follow-up, according to the involved site and lymphoma subtype. Existing, new and emerging endoscopic technologies have been examined. In particular, we investigated the diagnostic, prognostic and follow-up endoscopic features of T-cell and natural killer lymphomas, lymphomatous polyposis and mantle cell lymphoma, follicular lymphoma, plasma cell related disease, gastrointestinal lymphomas in immunodeficiency and Hodgkin's lymphoma of the gastrointestinal tract. Contrarily to more frequent gastrointestinal lymphomas, data about rare lymphomas are mostly extracted from case series and case reports. Due to the data paucity, a synergism between gastroenterologists and hematologists is required in order to better manage the disease. Indeed, clinical and prognostic features are different from nodal and extranodal or the bone marrow (in case of plasma cell disease) counterpart. Therefore, the approach should be based on the knowledge of the peculiar behavior and natural history of disease.

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Primary small-bowel adult T-cell leukemia/lymphoma with gastric AL amyloidosis

Cited by 3 publications

References 4 publications

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

Primary localized amyloidoma of the renal pelvis: A case report and literature review

Rare gastrointestinal lymphomas: The endoscopic investigation

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