Primary Sjogrens Syndrome in a Child

Kumar, K. Jagadish; Kudakesseril, Anush S.; Sheeladevi, CS; Sowmya, H V

doi:10.5812/ijp.254

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…With the help of different diametric, round‐ended ophthalmologic lacrimal sac probes first used by our group, parotid sialography with the use of 1.5‐2 mL Dionosyl‐F‐Aquosum, water‐solvent contrast substance, was carried out. In those patients with SS, we reinforced the diagnosis at the fulfillment of a least 4 criteria in accordance with current diagnostic consensus guidelines and following recommendations to avoid misdiagnosis with other disorders including RA, particularly in children …”

Section: Methodsmentioning

confidence: 98%

“…Fucosidase diagnosis was performed according to the previously reported methods . SS in children was diagnosed with the concurrent or alternative presence of bilateral parotid glands associated with dryness of mouth and/or eyes and with at least 1 of these tests (antinuclear antibodies, anti‐double‐stranded DNA, anti‐SSA, anti‐SSB) positive at ≥1:80 …”

Section: Methodsmentioning

confidence: 99%

“…In those patients with SS, we reinforced the diagnosis at the fulfillment of a least 4 criteria in accordance with current diagnostic consensus guidelines and following recommendations to avoid misdiagnosis with other disorders including RA, particularly in children. [20][21][22][23][24][25] The plasma enzyme activity of α-L-FUCA-1 was investigated in the Laboratory of the Pediatrics Department with a fluorimetric method. 26 The blood specimens were processed within 1-2 hours from the withdrawal and using sterile disposable plastic ware.…”

Section: Methodsmentioning

confidence: 99%

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Plasma α‐L‐fucosidase‐1 in patients with Sjögren's syndrome and other rheumatic disorders

et al. 2019

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Background Human α‐fucosidase (EC 3.2.1.51) is a hydrolase the importance of which has been increasing in the latest years. However, data about its plasma level in children with autoimmune disorders, particularly Sjögren's syndrome (SS), are lacking. In this study, the plasma activity of L‐α‐fucosidase‐1 (α‐L‐FUCA‐1) was assayed in hospitalized children and adults and its association with SS and other rheumatic disorders further evaluated. Methods In total 73 Hungarian hospitalized patients, 32 children (2.5‐10 years) and 41 adults (32‐68 years), were enrolled in the study and underwent plasma assay of α‐L‐FUCA1 activity. Linear regression, Durbin‐Watson (DW), and Pearson tests were evaluated to investigate the relationship between α‐L‐FUCA‐1 plasma levels and autoimmune manifestations. Results α‐L‐FUCA‐1 correlated with SS both in children (2‐sided t test, P = 0.0023) and in adults (2‐sided t test, P = 0.00035). Linear regressions showed that in other rheumatic disorders, α‐L‐FUCA1 did not show any differential distribution related to the particular pathology (r = 0.2042, P = 0.1531, DW test = 2.2139 positive), while this trend was radically opposite for patients with SS (r = 0.1462, P = 0.0032, DW test = 1.3664, negative). Conclusions Alterations in plasma level of α‐L‐FUCA‐1 were significantly associated with SS. This preliminary result should encourage further research on α‐L‐FUCA‐1 as a possible differential serological marker of SS.

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Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Plasma α‐L‐fucosidase‐1 in patients with Sjögren's syndrome and other rheumatic disorders

et al. 2019

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“…Sausa akis yra daugiaveiksnė akies paviršiaus liga, kuriai būdingas ašarų plėvelės homeostazės praradimas, dėl kurio akies paviršiuje (ragenoje ir junginėje) atsiranda pokyčiai bei akių simptomai, sukelti [13]. Pakitusi ašarų gamyba galima dėl Šjogreno sindromo -autoimuninio susirgimo, kurio metu pažeidžiama ašarų ir kitos liaukos [14], bei kitų, su šiuo sindromu nesusijusių, priežasčių -ašarų liaukų nepakankamumo (sergant sarkoidoze, limfoma), esant akių nudegimui, A vitamino trūkumui, vartojant kai kuriuos vaistus (nuo alergijos, veikiančius nervų sistemą, mažinančius kraujospūdį, peroralinius kontraceptikus) [15]. Viena dažniausių priežasčių -natūralus ašarų gamybos mažėjimas senstant, ypač moterims pomenopauziniu periodu [15].…”

Section: Tyrimo Rezultataiunclassified

Sausų Akių Sindromo Etiologijos, Diagnostikos Ir Gydymo Ypatumai

Mišeikytė¹,

Sereikaitė²,

Kužmarskytė³

2021

Health Sciences

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Sausų akių sindromas (SAS) – yra daugelio veiksnių sukeliama ašarų ir akių paviršių lėtinė liga, kuri pasireiškia nepakankama ašarų gamyba. Sausa akis yra daugiaveiksnė akies paviršiaus liga, kuriai būdingas ašarų plėvelės homeostazės praradimas, sukeliantis akies paviršiaus pokyčius ir akių simptomus: svetimkūnio jutimas akyje, deginimas, sausumas, paraudimas, kontaktinių lęšių netoleravimas, intensyvus ašarojimas, fotofobija, akių nuovargis ir skausmas. Šie simptomai pasireiškia dėl nepakankamo akių drėkinimo – pakitusios ašarų gamybos ar suintensyvėjusio ašarų nugaravimo. Diagnostiniai testai yra būtini atskirti SAS nuo infekcijų ar alergijų, kurios gali pasireikšti panašiais simptomais. SAS gydymas yra multietiologinis. Jis susideda iš vokų ligų gydymo, uždegimo mažinimo, ašarų tūrio ar kokybės gerinimo, gyvenimo būdo ir mitybos pokyčių.

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“…Tidak adanya kelenjar lakrimal utama sangat jarang terjadi. [7,25] Pengobatan ditujukan untuk menjaga integritas epitel kornea. Penggunaan pengganti air mata dalam jumlah besar, dalam bentuk cair, gel, atau salep, berfungsi untuk perlindungan mata.…”

Section: Biasanyaunclassified

Kelainan Sistem Lakrimal Pada Anak

Landani¹,

Himayani

2020

JIMKI

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Pendahulan: Sistem lakrimal terdiri dari berbagai kelenjar dalam menghasilkan air mata dan sistem drainase air mata. Epifora, atau air mata berlebih, adalah masalah yang sering terjadi pada anak atau bayi. Pembahasan: Etiologi yang paling sering dari gangguan ini adalah obstruksi duktus nasolakrimalis. Abnormalitas yang paling sering yaitu defek atau sumbatan pada sistem drainase, saluran nasolakrimal yang tersumbat. Sebagian besar bukti mendukung manajemen konservatif pada kasus ini, dilakukan pemeriksaan untuk mereka yang gagal teratasi pada usia satu tahun. Ada beberapa kondisi lain, beberapa di antaranya bisa serius, yang bisa menyebabkan banyaknya air mata. Infeksi pada kelopak mata dan konjungtiva, benda asing yang belum ditemukan, dan glaukoma bawaan adalah beberapa kondisi yang harus disingkirkan ketika ada anak yang mengalami air mata berlebihan. Simpulan: Diagnosis dan tatalaksana yang tepat pada kelaian sistem lakrimal pada anak akan mendapatkan prognosis yang lebih baik Kata kunci: air mata, anak, bayi, diagnosis, lakrimal

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Primary Sjogrens Syndrome in a Child

Cited by 7 publications

References 9 publications

Plasma α‐L‐fucosidase‐1 in patients with Sjögren's syndrome and other rheumatic disorders

Plasma α‐L‐fucosidase‐1 in patients with Sjögren's syndrome and other rheumatic disorders

Sausų Akių Sindromo Etiologijos, Diagnostikos Ir Gydymo Ypatumai

Kelainan Sistem Lakrimal Pada Anak

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