Primary Sjögren's syndrome

Rischmueller, Maureen; Tieu, Joanna; Lester, Susan

doi:10.1016/j.berh.2016.04.003

Cited by 97 publications

(100 citation statements)

References 121 publications

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“…Among women, the incidence of primary SS increases with age and peaks during the years of 55-65. In contrast, among men, primary SS is most common among individuals 65 years or older [5].…”

Section: Epidemiology Of Ssmentioning

confidence: 97%

“…SS is the second most common autoimmune rheumatic disease [2], with a prevalence of approximately 1% (range 0.1-4.8%) [2,4] and an incidence of about 7 per 100,000 person-years at risk [5,6]. In total, up to 4 million Americans have SS [7][8][9].…”

Section: Epidemiology Of Ssmentioning

confidence: 99%

“…Onset typically occurs during the 4th or 5th decade of life, but SS may occur at any age [11]. The overall age of primary SS patients at diagnosis has been reported to be 56 years (95% CI 53-60 years) [5]. Among women, the incidence of primary SS increases with age and peaks during the years of 55-65.…”

Section: Epidemiology Of Ssmentioning

confidence: 99%

See 2 more Smart Citations

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

et al. 2017

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“…Among women, the incidence of primary SS increases with age and peaks during the years of 55-65. In contrast, among men, primary SS is most common among individuals 65 years or older [5].…”

Section: Epidemiology Of Ssmentioning

confidence: 97%

Section: Epidemiology Of Ssmentioning

confidence: 99%

See 1 more Smart Citation

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

et al. 2017

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“…Serum hypergammaglobulinemia is a common finding in SS patients (Rischmueller et al , ). In addition, in a previous report, serum IgG and IgE levels were high in non‐obese diabetic (NOD).…”

Section: Resultsmentioning

confidence: 99%

Flagellar filament structural protein induces Sjögren's syndrome‐like sialadenitis in mice

et al. 2017

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“…Primary Sjogren's syndrome (pSS) is a typical autoimmune disease that predominantly affects middle‐aged women. It is characterized by chronic inflammation and the reduced secretory function of the exocrine glands, particularly the lacrimal and salivary glands, resulting in dry‐eye and dry‐mouth symptoms . Some patients also develop extraglandular manifestations, such as weakness and arthralgia.…”

Section: Introductionmentioning

confidence: 99%

Aberrant IL‐35 levels in patients with primary Sjogren's syndrome

Guo

Zhang

et al. 2018

Scand J Immunol

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Objective IL‐35 is a newly discovered immunoregulatory cytokine that possesses the ability to inhibit CD4 + effector T cells and alleviate autoimmune diseases. The objective of this study was to investigate IL‐35 levels in patients with primary Sjogren's syndrome (pSS) and explore the roles of IL‐35 in the pathogenesis of pSS. Methods Thirty‐four hospitalized patients with pSS were recruited, and 34 volunteers were enrolled as healthy controls. An ELISA was adopted to measure plasma IL‐35 levels. The levels of P35 and EBI3 mRNAs in peripheral blood mononuclear cells (PBMCs) were determined using real‐time quantitative PCR. The percentage of CD4 + EBI3 + T cells and CD19 + EBI3 + B cells was analysed using flow cytometry. Correlations between IL‐35 levels, P35 and EBI3 mRNAs, numbers of CD4 + EBI3 + T cells, CD19 + EBI3 + B cells and clinical parameters were analysed. Results Significantly lower plasma IL‐35 levels, P35 and EBI3 mRNA levels, and percentages of CD4 + EBI3 + T cells but increased percentages of CD19 + EBI3 + B cells were observed in patients with pSS than in healthy controls. IL‐35 levels, EBI3 mRNA expression and the percentage of CD4 + EBI3 + T cells exhibited negative correlations with the ESSDAI score, whereas levels of the IL‐35 protein and EBI3 mRNA were negatively correlated with the ESR. Patients who were positive for anti‐SSB antibodies presented with lower IL‐35 levels and percentages of CD4 + EBI3 + T cells. Conclusions Based on these results, a decrease in the IL‐35 levels may play an important role in the pathogenesis of pSS. IL‐35 may act as a potential therapeutic agent against inflammation in patients with pSS.

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Primary Sjögren's syndrome

Cited by 97 publications

References 121 publications

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

Flagellar filament structural protein induces Sjögren's syndrome‐like sialadenitis in mice

Aberrant IL‐35 levels in patients with primary Sjogren's syndrome

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