Primary Sjögren's syndrome presenting as a generalized Chorea

Fanchke, P. Venegas; Sinning, Mariana; Miranda, Mauricio

doi:10.1016/j.parkreldis.2004.10.006

Cited by 23 publications

(15 citation statements)

References 11 publications

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“…Autoimmune-mediated movement disorders are thought to occur in a number of autoimmune disorders, such as Sjögren’s Syndrome (van den Berg et al 1999; Venegas et al 2005; Papageorgiou et al 2007; Min and Youn 2009), Sydenham's chorea (Vincent et al 2011), and certain cases of Tourette’s Syndrome (Morer et al 2008; Dehning et al 2009). Methodologies currently exist that may provide clinically useful means to image neuroinflammation in these and other disorders.…”

Section: Introductionmentioning

confidence: 99%

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Cooper

Clark

2012

J Neuroimmune Pharmacol

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Complex Regional Pain Syndrome (CRPS) is associated with non-dermatomal patterns of pain, unusual movement disorders, and somatovisceral dysfunctions. These symptoms are viewed by some neurologists and psychiatrists as being psychogenic in origin. Recent evidence, however, suggests that an autoimmune attack on self-antigens found in the peripheral and central nervous system may underlie a number of CRPS symptoms. From both animal and human studies, evidence is accumulating that neuroinflammation can spread, either anterograde or retrograde, via axonal projections in the CNS, thereby establishing neuroinflammatory tracks and secondary neuroinflammatory foci within the neuraxis. These findings suggest that neuroinflammatory lesions, as well as their associated functional consequences, should be evaluated during the differential diagnosis of non-dermatomal pain presentations, atypical movement disorders, as well as other “medically unexplained symptoms”, which are often attributed to psychogenic illness.

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Section: Introductionmentioning

confidence: 99%

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Cooper

Clark

2012

J Neuroimmune Pharmacol

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“…Patient 1 had a hemisensory deficit with cognitive dysfunction, a CNS presentation often described in SS [3, 4]. Patient 2 presented with chorea, a previously reported atypical SS-related CNS manifestation [11]. Patient 3 had optic neuritis and recurrent acute transverse myelitis, a clinical presentation similar to neuromyelitis optica already described in SS-related CNS disease [12].…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Anti-SSA Autoantibodies in Primary Sjögren’s Syndrome with Central Nervous System Involvement

Mégevand

Chizzolini²,

Chofflon³

et al. 2007

Eur Neurol

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Background: Central nervous system involvement in primary Sjögren’s syndrome is a matter of controversy, and its diagnosis remains difficult. Methods: We report 3 patients with primary Sjögren’s syndrome and central nervous system involvement in whom we assessed intrathecal immunoglobulin G synthesis and the presence of cerebrospinal fluid anti-SSA and anti-SSB autoantibodies. Results: We found intrathecal immunoglobulin G synthesis and presence of cerebrospinal fluid anti-SSA autoantibodies in all patients, with demonstration for the first time of specific anti-SSA autoantibody intrathecal synthesis in 2 patients. Conclusion: We suggest that cerebrospinal fluid anti-SSA autoantibodies could serve as a biomarker for Sjögren’s-syndrome-related central nervous system involvement.

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“…The basal ganglia may be vulnerable in many systemic autoimmune disorders, including systemic lupus erythematosus [88,89], Sjögren's syndrome [90], and antiphospholipid antibody syndrome [91]. In polycythemia vera, chorea may be due either to autoantibodies or, as currently appears more likely, to hyperviscosity [92].…”

Section: Autoimmune Disordersmentioning

confidence: 99%

Diagnosis and Treatment of Chorea Syndromes

Hermann

Walker

2015

Curr Neurol Neurosci Rep

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Chorea is a common movement disorder which can be caused by a large variety of diseases including neurodegenerative diseases, metabolic diseases, and autoimmune diseases, or can be secondary to structural changes. The basal ganglia seem to be mainly involved in the pathophysiology indicating the vulnerability of this region. The diagnosis can be challenging, especially if chorea occurs during the treatment of neuropsychiatric conditions, and in these cases, it is difficult to distinguish between medication side effects (i.e., tardive dyskinesia) and the development of a neurodegenerative disease. Most therapeutic approaches are predominantly symptomatic, with a focus on multidisciplinary care for many patients. Nevertheless, some underlying diseases can be successfully treated and must not be missed. In this review, we summarize recent new developments in the differential diagnosis of chorea syndromes and suggest a pathway for a successful diagnosis of chorea in infancy, childhood, and adulthood for daily practice.

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Primary Sjögren's syndrome presenting as a generalized Chorea

Cited by 23 publications

References 11 publications

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Cerebrospinal Fluid Anti-SSA Autoantibodies in Primary Sjögren’s Syndrome with Central Nervous System Involvement

Diagnosis and Treatment of Chorea Syndromes

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