Primary Sjögren's syndrome in men

Molina, Rodolfo; Provost, Thomas T.; Arnett, Frank C.; Bias, Wilma Β.; Hochberg, Marc C.; Wilson, Raymond W.; Alexander, Elaine L.

doi:10.1016/0002-9343(86)90044-6

Cited by 95 publications

(37 citation statements)

References 24 publications

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“…A meta-analysis confirmed that the presence of EGM as well as number of EGM is more common in men with pSS. Similar trends have been previously reported for prevalent pSS, although statistical significance has been difficult to obtain due to the small number of men in the studies [32, 38, 47]. …”

Section: Discussionsupporting

confidence: 82%

“…Serological investigations performed in previous studies show considerable discrepancies between the frequencies of anti-Ro/SSA positivity among the male patients. Some papers highlight significant serological differences between the sexes with a tendency for men to be less frequently seropositive [34–36, 38], but the antibody levels in seropositive individuals are rarely compared. However, Drosos et al [36] reported that female patients have higher anti-Ro levels than males.…”

Section: Discussionmentioning

confidence: 99%

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Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

et al. 2017

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BackgroundA more severe disease phenotype has been reported in men compared to women in several rheumatic diseases. However, studies have not conclusively established sex-related clinical features in primary Sjögren’s syndrome (pSS). In this study, we therefore investigated the clinical presentation of pSS in women and men at diagnosis.MethodsIncident, treatment naïve patients (n = 199) during a 5-year period in a specified area were prospectively included and examined for items of classification criteria for pSS as well as extraglandular manifestations (EGM). Serum was sampled at the time of diagnosis and anti-Ro52/SSA levels were measured by ELISA. Replication of significant findings was confirmed in an independent cohort of pSS patients (n = 377), and meta-analysis was performed.ResultsAn increased frequency of extraglandular manifestations in men was observed and replicated (p = 0.05, p = 0.0003, and p meta = 0.002). This related to pulmonary involvement, vasculitis, and lymphadenopathy being more common in men, for whom a lower age at diagnosis was observed in the exploratory cohort. Additionally, SSA-positive male patients had significantly higher levels of anti-Ro52 levels than their female counterparts in sera available for analysis (p = 0.02).ConclusionsOur analysis of two independent cohorts of incident pSS demonstrates that the presence and number of EGM are significantly more frequent among men with pSS than women at diagnosis. Importantly, around half of the male patients presented with more than one EGM at diagnosis, supporting the conclusion that pSS in men represents a more severe form of disease, regardless of the lower risk for men to develop pSS.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

et al. 2017

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“…Additionally, the prevalence of other extraglandular manifestations (Raynaud's phenomenon and cutaneous vasculitis) in our male patients was slightly lower when compared with the prevalence observed in the female patients. Similarly, Drosos et al 9 found a lower prevalence of arthritis and Raynaud's phenomenon in Greek patients, but the two studies performed in American patients 7,8 showed that men were at the same risk for development of extraglandular complications (Table 2). These discrepancies may be due to differences in the criteria that have been used for the diagnosis of the clinical manifestations or may re¯ect the effects of patient selection or ethnic differences.…”

Section: Discussionmentioning

confidence: 91%

Primary Sjoögren's syndrome in men: clinical and immunological characteristics

Cervera

Font²,

Ramos‐Casals

et al. 2000

Lupus

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“…Significant serologic and immunogenetic differences between men and women have been reported. 7 In sharp contrast to women with SS, men with SS were seronegative with respect to the presence of serum rheumatoid factor and anti-SS-A antibody, although men were at the same risk of developing extraglandular complications.…”

Section: Discussionmentioning

confidence: 99%

Marked hypocomplementemia and tubulointerstitial nephritis in a male patient with Sj�gren?s syndrome

et al. 2004

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We report a case of marked hypocomplementemia and tubulointerstitial nephritis associated with Sjögren's syndrome (SS) in a male patient. Renal biopsy revealed tubulointerstitial nephritis but did not identify specific immune deposits of the tubulo-interstitium. After steroid therapy, the renal failure and hypocomplementemia diminished. Hypocomplementemia without cryoglobulinemia is not commonly observed in SS patients, and hypocomplementemic tubulointerstitial nephritis was strongly suspected. Hypocomplementemic tubulointerstitial nephritis is rare; only one case has been described in the literature. In our case and the previous case, the patients were elderly men, and they had some similar clinical characteristics. Idiopathic hypocomplementemic tubulointerstitial nephritis resembling our case has been reported. These facts suggest that hypocomplementemic tubulointerstitial nephritis may occur in patients with SS, and such cases may not be as rare as once thought because it might be appropriate to include them in the category of idiopathic cases. Such a syndrome should be included in the differential diagnosis of hypocomplementemia.

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Primary Sjögren's syndrome in men

Cited by 95 publications

References 24 publications

Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

Primary Sjoögren's syndrome in men: clinical and immunological characteristics

Marked hypocomplementemia and tubulointerstitial nephritis in a male patient with Sj�gren?s syndrome

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