Primary Sjögren’s Syndrome: Current Pathophysiological, Diagnostic and Therapeutic Advances

Delporte, Christine; Perret, Jason; Soyfoo, Muhammad Shahnawaz

doi:10.5772/20848

Cited by 2 publications

(2 citation statements)

References 164 publications

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“…SS is classified as either primary, when occurring alone, or secondary, when occurring along with another autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus or myositis. Although the origin of the disease remains unknown, epithelial cell activation is considered to play a central role in the multifactorial pathogenesis of SS [ 67 , 68 , 69 , 70 ]. Several autoantibodies have been detected in patients suffering from SS and associated with clinical features of SS; including against ribonucleoproteins (Ro/SS-A) and La/SS-B), CA19-9, muscarinic M3 receptors and pancreatic ductal cells [ 71 , 72 , 73 , 74 ].…”

Section: Aquaporins and Pathophysiological Conditionsmentioning

confidence: 99%

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Delporte

Bryla

Perret

2016

IJMS

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Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and is pointing out possible difference between major salivary glands, i.e., parotid, submandibular and sublingual glands.

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Section: Aquaporins and Pathophysiological Conditionsmentioning

confidence: 99%

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Delporte

Bryla

Perret

2016

IJMS

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“…As a consequence, AQPs inhibitors and gene therapy using viral vectors encoding AQPs have been developed [31,33,34,35,36,37,38]. In addition, AQPs are potential biomarkers for the diagnosis and prognosis of diseases, and in particular of cancers [29,39,40,41,42,43,44,45,46,47,48,49,50].…”

Section: Introductionmentioning

confidence: 99%

Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases

Arsenijević

Perret

Laethem

et al. 2019

IJMS

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Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer. Aquaporins may represent useful drug targets for the treatment of pathophysiological conditions affecting pancreatic function, and/or diagnostic/predictive biomarker for pancreatic cancer. This review summarizes the current knowledge related to the involvement of aquaporins in the pancreas physiology and physiopathology.

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Primary Sjögren’s Syndrome: Current Pathophysiological, Diagnostic and Therapeutic Advances

Cited by 2 publications

References 164 publications

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases

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