Primary Signet Ring Cell Mucinous Ovarian Carcinoma: A Case Report and Literature Review

El‐Safadi, Samer; Stahl, U.; Tinneberg, H.‐R.; Hackethal, Andreas; Muenstedt, Karsten

doi:10.1159/000323003

Cited by 16 publications

(22 citation statements)

References 26 publications

(27 reference statements)

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“…Signet-ring-cell is a malignant histological cell type which is predominantly seen in carcinomas. Signet ring cells have frequently been reported in association with carcinoma of stomach [1] , but signet ring cells have also been reported in carcinomas of other tissues including the prostate [2] , bladder, gallbladder [3] , breast, colon [4] , ovarian stroma [5,6] , eyelid [7,8] . There have also been occasional reports of metastatic signet ring cell carcinoma to the testis, spermatic cord and scrotum.…”

Section: Introductionmentioning

confidence: 99%

Primary classical seminoma of testis with foci of signet-ring-cell morphology: A case report and review of the literature including ESMO guidelines on management of seminoma of testis

Venyo

Baiden-Amissah

2012

JBGC

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Background: Signet-ring-cell carcinoma is a rare variant of mucinous adenocarcinoma. Only about 3 cases of primary testicular cancer with signet-ring-cell morphology have been reported so far in the literature. There is lack of knowledge regarding the biological behaviour of this type of tumour affecting the testis. Seminoma of the testis is quite common and its biological behaviour is well known. When a classical seminoma of the testis is found to be contemporaneously associated with signet-ring-cell morphology, in view of the absence of any detailed literature on this rare clinical entity, the biological behaviour of such a tumour cannot be predicted. Objectives:To report a case of Classical Seminoma of the testis interspersed with seminoma cells with signet-ring morphology. To review the literature on signet-ring-cell carcinomas including carcinomas of testis with signet-ring-cell morphology. To review the ESMO guidelines on management of seminoma of testis Results: A 32-year-old man came for urology consultation 11 months after he had noticed a lump in his left testis. He had a family history of testicular cancer. A hard lump clinically suspicious of a tumour was palpable in the lower pole of his left testis. The right testis felt normal on palpation. His serum Beta HCG level was raised. He had ultra-sound scan of testis which showed bilateral microlithiasis with a tumour in the left testis but no tumour in the right testis. He underwent left radical orchidectomy and histology of the testicular tumour revealed a classical testicular seminoma with foci of signet-ring -cell morphology based upon haematoxylin and eosin staining as well as positive immunostaining for CD117 and OCT 3 / 4. Literature review revealed paucity of literature on testicular tumours with signet-ring-cell morphology. Conclusions:There is paucity of literature on primary testicular tumours with signet-ring-cell morphology. In order to establish the biological behaviour of such tumours we would encourage pathologists and urologists to report cases of testicular tumours associated with signet-ring-cell morphology together with the long term biological behaviour of such tumours. They should also report on the percentage of testicular tumours that have signet-ring-cell morphology and their distribution whether patchy or diffuse. Ultrasound-scan of testis was required to establish the diagnosis of testicular cancer 82 in the patient. Ultrasound-scan of testis is useful in the investigation of a testicular lump. Ultrasound and CT scans are also useful for the follow-up of patients with testicular cancer and microlithiasis. IntroductionSignet-ring-cell is a malignant histological cell type which is predominantly seen in carcinomas. Signet ring cells have frequently been reported in association with carcinoma of stomach [1] , but signet ring cells have also been reported in carcinomas of other tissues including the prostate [2] , bladder, gallbladder [3] , breast, colon [4] , ovarian stroma [5,6] , eyelid [7,8] . There have also been occasional rep...

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Section: Introductionmentioning

confidence: 99%

Primary classical seminoma of testis with foci of signet-ring-cell morphology: A case report and review of the literature including ESMO guidelines on management of seminoma of testis

Venyo

Baiden-Amissah

2012

JBGC

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“…1 Signet-ring cell carcinoma of the cervix commonly represents a metastasis, usually from the stomach but less frequently from the colon, breast, lungs, appendix, gallbladder, bladder, or ovary. [4][5][6] Therefore, it is necessary to combine clinical, imaging, and endoscopic findings to identify other primary sites.…”

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Diagnosis of primary pure signet‐ring cell carcinoma of the cervix

Washimi

Yokose

Noguchi

et al. 2015

Pathology International

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“…In veterinary medicine, signet-ring cell carcinomas most frequently arise from the stomach in dogs (Sugihara et al 1991;Carrasco et al 2011). Signet-ring carcinomas arising from the ovary have not been reported in veterinary medicine but have been reported rarely in human medicine (El-Safadi et al 2010). …”

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confidence: 99%

“…Primary signet-ring cell carcinoma of the ovary is extremely rare with only a few cases reported in human medicine (McCluggage & Young 2008;El-Safadi et al 2010;Leen & Singh 2012). Several reports in older literature have previously described a primary signet-ring cell carcinoma of the ovary (Krukenberg tumor) in humans.…”

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confidence: 99%

“…It was later shown that a substantial proportion of these tumors were not ovarian primaries, but actually represented metastases from tumors elsewhere in the body, specifically the gastrointestinal tract (Young 2006). True primary ovarian carcinomas of mucinous morphology are typically low grade and low stage, where the tumors are limited to the ovaries and have very low likelihood of aggressive clinical behavior (McCluggage & Young 2008;El-Safadi et al 2010;Leen & Singh 2012). Features that favor primary ovarian origin include unilateral localization, large size (>12 cm), background endometriosis, and association with other ovarian pathology, such as adenofibroma or cystadenoma.…”

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