Primary signet‐ring cell/histiocytoid carcinoma of the eyelid expressing androgen receptors and treated with bicalutamide

Sakamoto, Keiko; Ito, Taisuke; Tanioka, Fumihiko; Fukamizu, Hidekazu; Tokura, Y.

doi:10.1111/1346-8138.13915

Cited by 12 publications

(17 citation statements)

References 5 publications

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“…On immunohistochemistry, there was androgen receptor stain positivity in our case. Accounting for the case documented by Sakamoto et al [5], this is the second case of primary signet-ring cell/histiocytoid carcinoma where androgen receptor stain positivity is reported. In such cases, anti-androgen therapy may have a role in the management of this tumour.…”

Section: Discussionmentioning

confidence: 60%

“…In review of cases by Tamboon et al, the recurrence free period ranged from 5 months to 8 years [3]. Of the 33 total documented cases of primary cutaneous signet-ring cell/ histiocytoid carcinoma, ten developed metastases over a 10 year follow-up period [1,[3][4][5][10][11][12][13][14][15]. The most common metastatic sites are regional lymph nodes but can also include skin of the head, neck, trunk, respiratory tract, vulva, bone marrow, spine and parotid gland [3].…”

Section: Discussionmentioning

confidence: 99%

“…There are 32 reported cases of primary signet-ring cell/histiocytoid carcinoma in the English literature [ 1 – 5 , 10 – 28 ]. Our case represents the 33th case of primary signet-ring cell/histiocytoid carcinoma of the eyelid in a 73 year old male, and illustrates the diagnostic and treatment challenges of this tumour.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

2020

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Background Primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid is an extremely rare but aggressive neoplasm diagnosed primarily in elderly men. Until now there are 32 published cases of signet-ring cell carcinoma or histiocytoid carcinoma of the eyelid. We report the clinical, radiographic and histological features of the 33rd reported case of PCSRCC in the eyelid of a 73-year-old male, and review diagnostic and treatment challenges of this rare entity. Case presentation Our case highlights a 73-year-old male who was referred for surgical correction of right eye ptosis that was present for 2 years. Upon assessment, he was noted to have an upper lateral orbital rim mass. Computed tomography (CT) noted ill-defined soft tissue thickening anterior to the right globe, predominantly pre-septal but with slight post-septal extension. The pathology revealed diffusely and deeply infiltrating tumour cells extending through the dermis, subcutis, orbicularis muscle bundles and nerve fibers; the tumour cells were noted to have a monotonous histiocytoid appearance with foamy granular eosinophilic cytoplasm. At high magnification, intracytoplasmic vacuoles and occasional intermixed signet ring cells were identified. Immunohistochemical staining revealed the tumour cells to be AE1/AE3, CK7, GCDFP-15, E-cadherin, androgen receptor stain and GATA3 positive. Final pathology report confirmed the diagnosis of primary cutaneous signet-ring cell/histiocytoid carcinoma. Further imaging failed to identify a distant primary malignancy or metastatic disease. The decision was made to attempt surgical excision of the tumor. After the bulk of the grossly apparent tumor was removed, intraoperative frozen sections were sent. Superficial biopsies of the right periorbital region were performed, which revealed extension significantly further than the gross disease. Thereafter, the patient underwent a wide orbital exenteration with reconstruction using a temporary split-thickness skin graft. Due to positive margins on final permanent sections, the patient underwent further wide resection with free muscle-skin flap reconstruction followed by adjuvant radiation treatment. Conclusion Our case represents the 33rd case of primary signet-ring cell/histiocytoid carcinoma of the eyelid in a 73-year-old male, the first documented case with GATA3 positivity and the second documented case with androgen receptor stain positivity.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

2020

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“…Histology typically reveals a deep dermal and subcutaneous infiltration of single/short cords of tumour cells, with extension into the orbit and surrounding soft tissue . Pagetoid spread into the epidermis is exceptional, but has been described, and most cases spares the epidermis. A similar tumour with regard to morphology and immunophenotype has rarely been described in the axilla …”

Section: Discussionmentioning

confidence: 99%

A rare eyelid tumour in an elderly man

et al. 2018

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“…Metastases have occurred in around half of the reported cases, usually to nearby lymph nodes [2,12]. Tumor-related deaths have also been described [6,13,18,19]. The periorbital lesions often present as diffuse swelling and thickening of the involved lid, with normal or erythematous skin, and tend to infiltrate circumferentially around the eyelid, leading to their "monocle-like" appearance [20].…”

Section: Introductionmentioning

confidence: 99%

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

et al. 2018

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Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

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Primary signet‐ring cell/histiocytoid carcinoma of the eyelid expressing androgen receptors and treated with bicalutamide

Cited by 12 publications

References 5 publications

Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

A rare eyelid tumour in an elderly man

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

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