Primary Signet-Ring Cell Carcinoma of the Urinary Bladder Successfully Managed with Radical Cystectomy in a Young Patient

Allameh, Farzad; Nilipour, Yalda; Rakhshan, Azadeh

doi:10.1155/2017/9121078

Cited by 7 publications

(14 citation statements)

References 7 publications

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“…The second theory suggests that the tumor originates from normal, isolated signet‐ring cells that scatter along the urothelium. The final theory proposes that these cells arise directly from totipotent urothelial cells, without passing through metaplasia 3–5 …”

Section: Discussionmentioning

confidence: 99%

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Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case

et al. 2022

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Introduction Signet‐ring cell carcinoma is an extremely rare histological variant of upper urinary tract carcinoma, associated with poor prognosis. Case presentation We report a case of a 75‐year‐old female diagnosed with left primary upper urinary tract signet‐ring cell carcinoma, initially treated with surgery. Post‐surgical development of multifocal metastases was followed by a devastating clinical course. An autopsy confirmed the tumor's primary origin in the upper urinary tract. Conclusion We experienced a case of upper urinary tract signet‐ring cell carcinoma, with a rare opportunity to thoroughly confirm its primary site with an autopsy.

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Section: Discussionmentioning

confidence: 99%

“…The most common primary site for SRCC is the gastrointestinal tract 1,4 . SRCC in the urinary tract secondary to gastric SRCC has been frequently reported, and thus distinguishing the true origin of this tumor poses a clinical challenge 3,4 .…”

Section: Discussionmentioning

confidence: 99%

Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case

et al. 2022

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“…SRCC of the urinary bladder is a rare but aggressive histological variant with poor survival prognosis. Owing to the rarity of SRCC, it is often neglected, and most previous studies of the disease were case reports ( 6 , 12 , 13 ). To a certain extent, the American Joint Committee on Cancer staging system is regarded as a routine tool to predict prognosis, mainly based on T, N, and M information.…”

Section: Discussionmentioning

confidence: 99%

Nomograms to predict individual prognosis of patients with primary signet ring cell carcinoma of the urinary bladder

Ma¹,

Wang²,

Tian³

et al. 2021

Transl Cancer Res TCR

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Background: Signet ring cell carcinoma (SRCC) is a rare but highly malignant variant of bladder carcinoma. Nomograms have demonstrated good accuracy in predicting the prognosis and guiding the management of pure urothelial carcinoma (UC). However, no accurate and applicable nomogram has been formulated for primary SRCC cases. This study aimed to determine significant prognostic factors and to construct nomograms for predicting the survival outcomes of patients with primary SRCCs of the urinary bladder.Methods: A total of 317 eligible patients diagnosed with SRCC were analyzed using the 2004-2016 data from the Surveillance, Epidemiology, and End Results database. Univariate and multivariate analyses were performed to explore the prognostic values. Nomograms were established to estimate the overall survival (OS) and cancer-specific survival (CSS) based on the Cox regression results. The performance of SRCC nomograms was evaluated using the concordance index and calibration curves. Survival curves were applied according to various surgical methods, lymph node status, and risk groups distinguished by nomograms.Results: Two nomograms included common indicators that were significantly associated with OS and CSS, including T stage, M stage, tumor size, surgery, and the lymph node ratio (LNR). The nomograms indicated appreciable accuracy in predicting the OS and CSS, with concordance index of 0.723 [95% confidence interval (CI) =0.692-0.754] and 0.740 (95% CI =0.701-0.779), respectively. The calibration curves revealed satisfactory consistency between the prediction of deviation correction and ideal reference line. Conclusions:The two nomograms developed in this study showed high accuracy and reliability in predicting the survival outcomes of patients with SRCC and could be used to comprehensively assess the risk of SRCC. Moreover, they could assist in the optimal treatment selection for such patients.

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“…Gross hematuria has a wide differential diagnosis (1)(2)(3)(4). Primary prostate sarcoma, which derives from the mesenchymal cells of the prostate stroma and is responsible for less than 0.1% of primary prostate cancers, was first reported in 2003.…”

Section: Introductionmentioning

confidence: 99%

Painless Gross Hematuria: A New Presentation of Primitive Neuroectodermal Tumor of the Prostate

et al. 2019

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Introduction: Primitive neuroectodermal tumor (PNET) is a very rare type of prostate sarcoma that mostly occurs in young adults, and it is associated with a poor prognosis. Case Presentation: A 37-year-old male was admitted with intermittent painless gross hematuria from 1 month prior to admission. Cystosocopy, abdominopelvic computed tomography scan (ACTS), and magnetic resonance imaging (MRI) revealed huge prostate. All tumor markers were negative and pathology findings of trans-rectal ultrasonographic biopsy (TRUS Bx) and trans-urethral resection of prostate (TURP) were consistent with severely inflamed prostatic urethra with no evidence of malignancy. The patient underwent radical prostatectomy. Histopathology of the specimens showed malignant neoplasm of small round and oval cells suggestive of PNET. Immunohistochemistry (IHC) study results on CD99 were positive. Conclusions: We report a rare uncommon case of prostate PNET presented by intermittent painless gross hematuria. As the prognosis is very poor, medical staff should pay enough attention to the differential diagnosis, choosing the best treatment and subjects close follow-up.

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Primary Signet-Ring Cell Carcinoma of the Urinary Bladder Successfully Managed with Radical Cystectomy in a Young Patient

Cited by 7 publications

References 7 publications

Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case

Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case

Nomograms to predict individual prognosis of patients with primary signet ring cell carcinoma of the urinary bladder

Painless Gross Hematuria: A New Presentation of Primitive Neuroectodermal Tumor of the Prostate

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