Primary Signet Ring Cell Carcinoma of the Prostate: A Rare Case Report

Gök, Alper; Tuygun, Can; Akmansu, Müge; Uslu, Ayşegül; Kartal, İbrahim; Sandıkçı, Fatih; Karabacak, Osman Raif; Sağnak, Azmi Levent; Topaloğlu, Hikmet; Ersoy, Hamit

doi:10.3390/jcm7080218

Cited by 13 publications

(23 citation statements)

References 8 publications

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“…Other less common primary sites of SRCC are the breast, pancreas, bladder, thyroid, and the lungs [6-7]. Primary SRCC of the prostate is even more rare, with roughly 60 cases reported in the literature [7]. In our patient with peritoneal carcinomatosis and rectal adhesions, a primary gastrointestinal malignancy was considered.…”

Section: Discussionmentioning

confidence: 99%

“…Another unique finding, in this case, was the histologic morphology of signet ring cells in the ascitic fluid. Signet-ring cell carcinoma (SRCC) is a rare form of cancer that carries a poor prognosis and is most commonly found in the stomach and colon [6-7]. Other less common primary sites of SRCC are the breast, pancreas, bladder, thyroid, and the lungs [6-7].…”

Section: Discussionmentioning

confidence: 99%

“…Signet-ring cell carcinoma (SRCC) is a rare form of cancer that carries a poor prognosis and is most commonly found in the stomach and colon [6-7]. Other less common primary sites of SRCC are the breast, pancreas, bladder, thyroid, and the lungs [6-7]. Primary SRCC of the prostate is even more rare, with roughly 60 cases reported in the literature [7].…”

Section: Discussionmentioning

confidence: 99%

“…His immunohistochemistry staining was positive for PSA and Ber-EP4 making SRCC of prostatic origin the most likely case. However, given there were no standardized treatment modalities for primary SRCC of the prostate, we pursued standardized treatment for prostate adenocarcinoma [7].…”

Section: Discussionmentioning

confidence: 99%

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Prostate Cancer Metastatic to the Peritoneum: A Road Less Traveled by a Common Malignancy

Tareen

Rodríguez

2019

Cureus

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A 70-year-old Indian male with a history of a Gleason 7 (3+4) prostate cancer presented with abdominal ascites. Imaging was remarkable for peritoneal carcinomatosis as well as possible metastases to the bladder and seminal vesicle. Given the atypical pattern of presentation, further investigation was performed with studies of the ascites fluid. Cytology from the ascites fluid returned consistent with malignant cells of prostatic origin. His treatment course included androgen deprivation therapy (ADT), docetaxel, abiraterone, and cabazitaxel. He had eventual progression and worsening of his disease and performance status and was transitioned to hospice. This case demonstrated the importance of pursuing a thorough diagnostic evaluation, when faced with a rare presentation of a common malignancy. Furthermore, it illustrated the challenges incurred when tailoring standard regimens to best address the needs of the whole patient and not simply their disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prostate Cancer Metastatic to the Peritoneum: A Road Less Traveled by a Common Malignancy

Tareen

Rodríguez

2019

Cureus

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“…Lilleby et al [9] presented that at 12 months after initiation of HT+RT combination therapy, one of their patients was able to control the disease without distant metastasis. Alpergok et al [10] reported that a patient who received HT+RT combined treatment also achieved a survival of 16 months without disease progression. Cheng et al [11] reported 23 PPSRCC cases which were treated with RP+HT and HT+RT.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Primary Prostatic Signet Ring Cell Carcinoma: Single Center Experience

Tang

Zhou³

et al. 2021

Preprint

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Background: Primary prostatic signet ring cell carcinoma (PPSRCC) is an extremely rare malignant tumor without definitive treatment approach. Herein, we retrospectively summarized the experience of diagnosis and management of ten PPSRCC cases. Methods: A total of ten PPSRCC patients were included in this study definitely diagnosed by postoperative pathology at the First Affiliated Hospital of Nanjing Medical University from November 2001 to December 2020. Clinical characteristics, image features, therapeutic procedures, histological diagnosis and outcomes of them were retrospectively analyzed. Results: Characteristics of the patient population were ten males with age of 67.8±7.2 years. Among them, five cases were asymptomatic and five were manifested as dysuria. All ten patients received PSA examination preoperatively. Nine patients of ten accepted multiparametric MRI due to elevated PSA value, and further adopted prostatic biopsy. Among them, five patients were diagnosed as prostatic adenocarcinoma, and the other four cases were found a mixture of SRCC and adenocarcinoma. The above nine patients accepted laparoscopic or robot-assisted radical prostatectomy. Only one patient with normal PSA value adopted TURP. Postoperatively pathological results confirmed SRCC mixed with prostatic adenocarcinoma in nine cases, and only one patient with pure SRCC. After surgery, nine patients received adjuvant hormone therapy, one of which accepted radiotherapy simultaneously. The other one patient with pure SRCC didn’t accept any adjuvant therapy. None of the ten cases had gastrointestinal tumor history. During a mean follow-up of 43.6 months, eight patients were alive without obvious disease progression. Conclusions : In summary, PPSRCC is a rare malignant tumor with few early symptoms, highly malignancy, rapid disease progression and poor prognosis. PPSRCC is frequently accompanied by high grade prostate adenocarcinoma patterns. Early diagnosis and timely radical resection of prostate cancer, endocrine therapy, radiotherapy and chemotherapy may improve the prognosis.

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A Rare Case of Signet Ring Cell Carcinoma of the Colon With Selective Metastasis to the Prostate

Park

Snow

Lurz

et al. 2020

Urology

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Primary Signet Ring Cell Carcinoma of the Prostate: A Rare Case Report

Cited by 13 publications

References 8 publications

Prostate Cancer Metastatic to the Peritoneum: A Road Less Traveled by a Common Malignancy

Prostate Cancer Metastatic to the Peritoneum: A Road Less Traveled by a Common Malignancy

Diagnosis and Management of Primary Prostatic Signet Ring Cell Carcinoma: Single Center Experience

A Rare Case of Signet Ring Cell Carcinoma of the Colon With Selective Metastasis to the Prostate

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