Primary signet ring cell carcinoma of the cervix: A case report and review of the literature

Abstract

HighlightsTo date, only 18 cases with primary signet cell carcinoma of the cervix has been reported.Differentiation of primary tumour from metastatic signet cell carcinoma carries significant important while treatment and prognosis differ significantly.

A New Case of Primary Signet Ring Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

“…No case was reported with negative p16 immunohistochemical staining [13]. In our case, as well as in some previous published examples of the PCSRCC, the primary cervical origin was supported by the presence of P16 Immunoreactivity [12,13], which may be considered a surrogate marker for HPV infection [4]. The absence of extra genital pathology, demonstrated by investigations at the moment of the diagnosis and later in the course of the disease, also supports this opinion [7].…”

“…The presence of HPV 18 has been determined in five cases of primary signet-ring cell carcinoma of the cervix [4,7,[11][12][13]. No case was reported with negative p16 immunohistochemical staining [13]. In our case, as well as in some previous published examples of the PCSRCC, the primary cervical origin was supported by the presence of P16 Immunoreactivity [12,13], which may be considered a surrogate marker for HPV infection [4].…”

“…Positivity of Human Papillomavirus (HPV) DNA using molecular analysis provides diagnostic evidence of primary signet-ring cell carcinoma of the cervix [4,5]. The presence of HPV 18 has been determined in five cases of primary signet-ring cell carcinoma of the cervix [4,7,[11][12][13]. No case was reported with negative p16 immunohistochemical staining [13].…”

Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus–Positive and Human Papillomavirus–Negative Tumors

“…58 Primary cervical signet ring cell tumors of the cervix are rare. 59,60 Tumors arising in a background of usual ADC were shown to be HPV positive. 60…”

“…Of the reported cases, the tumors were positive for p16, CK7, and CEA, with variable staining for enteric and neuroendocrine markers. 59,60…”