Primary Signet Ring Cell Adenocarcinoma of the Bladder With Elevated Serum Carbohydrate Antigens 19-9 and 50

Ohnita, Tohru; Sakai, Hideki; Matsuo, M.; Hisamatsu, Hiroshi; Shimokawa, Isao; Saito, Yutaka

doi:10.1097/00005392-199805000-00064

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Indeed, the secretion level in culture medium of another tumor-associated antigen, CA19-9, was enhanced 14-fold after the induction of pBD110 (data not shown). Such enhanced function of the secretion system is typically observed in the cells of signet ring cell carcinomas (32). Immunostaining of pBD110 with anti-myc antibody revealed that this protein localized in the plasma membrane and the vacuole membrane, implicating the location of the targets of PI 3-kinase in these cells.…”

Section: Resultsmentioning

confidence: 80%

Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase

Kobayashi

Nagata

Iwasaki

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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Section: Resultsmentioning

confidence: 80%

Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase

Kobayashi

Nagata

Iwasaki

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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“…Some patients failed to respond to standard platinum-based chemotherapy for bladder cancer, but derived a significant clinical benefit from colon cancer type regimens such as 5-fluorouracil-based regimens or capecitabine [33][34][35] . Serum CA19-9 and CEA levels were found to be useful biomarkers to assess treatment efficacy in this tumor entity [36] . Multi-institution clinical trials are needed to establish a better therapeutic protocol for this rare but aggressive cancer [37] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Wang

2011

Urol Int

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Objective: The aim of this study was to examine the epidemiology, natural history, treatment pattern and predictors of long-term survival of patients with signet-ring cell carcinoma (SRCC) of the urinary bladder based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods and Results: In total, 230 patients with pathologically confirmed SRCC of the urinary bladder were identified between 1973 and 2004. The mean age was 65 ± 13 years. Overall, 75.7% of the patients had a poorly differentiated or undifferentiated histology grade, 26.5% presented with metastatic disease, 59 (25.7%) underwent transurethral resection for bladder tumor only and 107 (46.5%) had partial or radical cystectomy. The 1-, 3- and 10-year cancer-specific survival rates were 66.8, 40.6 and 25.8%, respectively. Using multivariable Cox proportional hazard model, age (HR 1.024; p = 0.004), stage (distant vs. local, HR 6.2; p < 0.001) and cystectomy (HR 0.53; p = 0.002) were identified as independent predictors for cancer-specific survival. Conclusions: Receipt of cystectomy was strongly associated with improved survival in the patients with SRCC of urinary bladder. However, many patients with localized tumors did not receive potentially curative cystectomy. Further studies to address the barriers to the delivery of appropriate care to these patients are warranted.

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Systematic Review: Seventy-Seven Cases of Signet Ring Cell Adenocarcinoma of the Bladder

Chew,

Boot,

Wilson

et al. 2024

SIUJ

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Background: Signet ring cell adenocarcinoma (SRCC) of the bladder is a rare and aggressive histological subtype of bladder cancer. Due to its infrequency, the understanding of its clinical behaviour, treatment strategies, and outcomes remains limited, being primarily derived from isolated case reports and series. Objective: To systematically review and analyse the available literature on SRCC of the bladder, emphasizing its clinical characteristics, diagnostic approaches, treatment modalities, and outcomes. Material and Methods: A comprehensive search was conducted across PubMed, Embase, and Medline following the PRISMA guidelines, including case reports, case series, observational studies, and clinical trials reporting on bladder SRCC. Results: We included 38 articles reporting on 77 patients, primarily males (79.2%), with a median age of 64 years. The most common presenting symptoms were haematuria (64.8%) and lower urinary tract symptoms (46.3%). All the diagnoses were based on histopathological examination of bladder tissue samples and immunohistochemistry. Mixed histological types of bladder cancer were found in 20.7% of cases, most commonly urothelial carcinoma (61.1%). The treatments varied, with 53.2% of patients undergoing radical cystectomy, 24.7% receiving radiotherapy, and 16.9% receiving chemotherapy. The five-year survival rates were 9.4%. Conclusion: Bladder SRCC presents aggressively, with varied treatment strategies; however, radical cystectomy appears to be the optimal means of surgical management for organ-confined disease. The overall survival rate is low, highlighting the need for further research to understand and manage this rare bladder cancer variant. All patients should undergo evaluation to exclude extravesical primaries. This systematic review contributes to a better understanding of this disease and may guide clinical management strategies.

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Primary Signet Ring Cell Adenocarcinoma of the Bladder With Elevated Serum Carbohydrate Antigens 19-9 and 50

Cited by 3 publications

References 4 publications

Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase

Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Systematic Review: Seventy-Seven Cases of Signet Ring Cell Adenocarcinoma of the Bladder

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