Water and wastewater treatment chemicals specifically coagulants such as iron salts are used in many different process units of the urban water system, including water treatment plants, sewer networks, wastewater treatment plants, and anaerobic digesters. The use of iron salts is mainly driven by each given process unit without the consideration of the flow-on effects to the downstream systems. This work aims to demonstrate the benefits of the multiple re-uses of iron in the urban water system, through the development of a laboratory scale reactor system simulating the integrated urban wastewater system. This integrated and innovative strategy will set an example of how to achieve major environmental and economic benefits through the holistic management of urban water and wastewater operations. Specifically, this thesis investigated the (1) effects of sewer-dosed iron salts on the wastewater treatment process through a comprehensive laboratory assessment using the reactor system, (2) the effects of insewer iron rich drinking water sludge on wastewater collection and treatment systems, and (3) the impact of primary sedimentation on the multiple use of iron in the urban wastewater system. A comprehensive laboratory assessment of the effects of iron-dosing in the sewer system on the wastewater treatment process was investigated in Chapter 5. A developed laboratory scale system comprising sewer reactors, wastewater treatment reactors. Sludge thickeners and anaerobic digesters were used. Two systems, fed with real domestic wastewater, were operated for over a year. The experimental system received ferric chloride (FeCl3) dosing at 10 mgFe L-1 in the sewer reactor whereas the control system received none. Wastewater, sludge, and biogas were extensively sampled and analysed for relevant parameters. The FeCl3-dosed experimental system displayed a decreased sulfide concentration (by 4.3 ± 0.5 mgS L-1) in sewer effluent, decreased phosphate concentration (by 4.7 ± 0.5 mgP L-1) in biological treatment reactor effluent, and decreased hydrogen sulfide concentration in biogas (911.5 ± 189.9 ppm to 130.0 ± 5.9 ppm), as compared with the control system. The biological nitrogen removal performance of the treatment reactor and biogas production in the anaerobic digester was not affected by FeCl3-dosing. Furthermore, the dewaterability of the anaerobically digested sludge was enhanced by 17.7 ± 1.0 %. These findings demonstrate that iron-dosing to sewers can achieve multiple benefits including sulfide removal in sewers, phosphorus removal during wastewater treatment, and hydrogen sulfide (H2S) removal during biogas generation. Drinking water production that uses FeCl3 as a coagulant produces waste sludge rich in iron. We hypothesised that the iron-rich drinking water sludge (DWS) can potentially be used in the I acknowledge that copyright of all material contained in my thesis resides with the copyright holder(s) of that material. Where appropriate I have obtained copyright permission from the copyright holder to reproduce material...