Primary Sclerosing Cholangitis and Its Relationship to the Colon in a Black Cohort of Inflammatory Bowel Disease Patients

Koczka, Charles; Geraldino‐Pardilla, Laura; Lawlor, Garrett

doi:10.1097/mcg.0b013e31829455b5

Cited by 4 publications

(6 citation statements)

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“…Limited data from other parts of the world suggest a lower PSC prevalence there compared to the United States and northern Europe 12–15. Within the United States, African Americans appear to be affected by PSC at rates similar to Whites 16–18. Peak incidence of PSC is between the ages of 25 and 45 years, with a median age at diagnosis ranging from 36 to 39 years; but PSC can occur at any age 19–21.…”

Section: Epidemiology Of Pscmentioning

confidence: 99%

“…[12][13][14][15] Within the United States, African Americans appear to be affected by PSC at rates similar to Whites. [16][17][18] Peak incidence of PSC is between the ages of 25 and 45 years, with a median age at diagnosis ranging from 36 to 39 years; but PSC can occur at any age. [19][20][21] In children, the incidence rate has been estimated to be 0.2 per 100,000 person-years.…”

Section: Epidemiology Of Pscmentioning

confidence: 99%

“…Women with PSC are generally older at diagnosis. At least 70%–80% of patients with PSC have concurrent IBD, and the prevalence of PSC in patients with IBD including non‐Europeans and children has been estimated to be 0.6%–4.3% 18,23–35. PSC‐AIH overlap occurs in up to 35% of children and 5% of adults with PSC 36–38.…”

Section: Epidemiology Of Pscmentioning

confidence: 99%

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AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

et al. 2022

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Inclusion of guidance for the diagnosis and management of cholangiocarcinoma (CCA) in patients with and without primary sclerosing cholangitis (PSC) (Figures 5, 8, and 9). Introduction of the term relevant stricture, defined as any biliary stricture of the common hepatic duct or hepatic ducts associated with signs or symptoms of obstructive cholestasis and/or bacterial cholangitis (Table 1). In patients with equivocal MRI with cholangiopancreatography (MRI/MRCP) findings, a repeated high-quality MRI/ MRCP should be performed for diagnostic purposes. Endoscopic retrograde cholangiopancreatography (ERCP) should be avoided for the diagnosis of PSC (Figure 2).

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Section: Epidemiology Of Pscmentioning

confidence: 99%

Section: Epidemiology Of Pscmentioning

confidence: 99%

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AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

et al. 2022

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“…After removing duplicates, irrelevant studies and studies not fulfilling the eligibility criteria, 23 studies were ultimately included in this meta-analysis, including nine retrospective case–control studies, seven prospective cohort studies, six retrospective cohort studies and one population-based cohort study. 16 – 38 A total of 1572 CD patients with IMIDs and 35,043 CD patients without IMIDs were included. Among the IMIDs, CD behavior and localization was most extensively investigated in relation to PSC in a total of eight studies.…”

Section: Resultsmentioning

confidence: 99%

“…Among the IMIDs, CD behavior and localization was most extensively investigated in relation to PSC in a total of eight studies. 16 , 19 – 21 , 32 , 36 – 38 The remaining studies investigating CD patients with co-occurring ankylosing spondylitis and sacroiliitis, 17 , 18 , 22 autoimmune pancreatitis, 23 axial spondyloarthropathy, 24 celiac disease, 25 , 27 erythema nodosum, 29 , 35 multiple sclerosis, 31 psoriasis 34 and uveitis 28 were pooled in the group ‘IMIDs other than PSC’.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis: the impact of co-occurring immune-mediated inflammatory diseases on the disease localization and behavior of Crohn’s disease

Attauabi

Zhao

Bendtsen

et al. 2021

Therap Adv Gastroenterol

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Background: Patients with Crohn’s disease (CD) are at increased risk of co-occurring immune-mediated inflammatory diseases (IMIDs). As discrepancy exists regarding the phenotypic presentation of CD among patients with such co-occurring IMIDs, we aimed to conduct a systematic review with meta-analysis characterizing the phenotype of CD among this subgroup of patients. Methods: PubMed, Embase, and Scopus were searched from their earliest records to October 2019 for studies reporting the behavior and localization of CD according to the Vienna or Montreal Classifications and CD-related surgery in patients with co-occurring IMIDs. These studies were the subject of a random effect meta-analysis. Results: After reviewing 24,413 studies, we identified a total of 23 studies comprising 1572 and 35,043 CD patients with and without co-occurring IMIDs, respectively, that fulfilled our inclusion criteria. Overall, patients with co-occurring IMIDs were more likely to have upper gastrointestinal inflammation than were patients without co-occurring IMIDs [relative risk (RR) = 1.49 (95% confidence interval (CI) 1.09–2.04), p = 0.01, I2 = 7%]. In addition, presence of primary sclerosing cholangitis (PSC) was associated with a lower occurrence of ileal affection [RR = 0.44 (95% CI 0.24–0.81), p < 0.01, I2 = 32%], increased occurrence of colonic affection [RR = 1.78 (95% CI 1.33–2.38), p < 0.01, I2 = 32%] and an increased likelihood of non-stricturing and non-penetrating behavior [RR = 1.43 (95% CI 0.97–2.11), p = 0.07, I2 = 86%]. The latter reached significance when cumulating different IMIDs [RR = 1.30 (95% CI 1.09–1.55), p < 0.01, I2 = 88%]. CD patients with PSC also underwent fewer CD-related surgeries [RR = 0.55 (95% CI 0.34–0.88), p = 0.01, I2 = 0%], irrespective of CD location or behavior. Conclusion: This study emphasizes that CD patients with co-existing PSC are likely to have a unique inflammatory distribution primarily confined to the colon, while patients with IMIDs in general have higher likelihood of affection of upper gastrointestinal tract and a non-stricturing and non-penetrating behavior. As such a phenotype of CD is typically associated with a milder disease course; future studies are needed to confirm these results.

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Primary sclerosing cholangitis hospitalizations in the United States: characteristics and predictors of clinical outcomes

Elfert,

Abosheaishaa,

Aboursheid

et al. 2023

Baylor University Medical Center Proceedings

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Primary Sclerosing Cholangitis and Its Relationship to the Colon in a Black Cohort of Inflammatory Bowel Disease Patients

Abstract: With greater research, physicians will better recognize IBD phenotypes at highest risk of PSC and hopefully identify complications of PSC, including cholangiocarcinoma.

Cited by 4 publications

References 1 publication

AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

Systematic review and meta-analysis: the impact of co-occurring immune-mediated inflammatory diseases on the disease localization and behavior of Crohn’s disease

Primary sclerosing cholangitis hospitalizations in the United States: characteristics and predictors of clinical outcomes

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