Primary Sarcomas of the Temporal Bone

Primary Intracranial Myxoid Chondrosarcoma: Report of a Case and Review of the Literature

“…The tumor in present case was located just beneath the cortex so that the leptomeningeal tissue or a vessel in the depths of the sulcus might be a possible origin. This hypothesis was suggested by some authors (13,22) and our case might be an example.…”

“…Theoretically, a chondrosarcoma should originate from the mesenchymal tissues, like cartilage, therefore, those arising from the skull base are quite natural. Intracranial chondrosarcomas are also thought to arise from the mesenchymal elements of the central nervous system, such as, the primitive multipotential mesenchymal cells or their mature descendents (fibroblasts, meningeal cells, and pial cells) located within the leptomeninges, the pia-arachnoid surrounding blood vessels or in the vessel walls, the stroma of the choroid plexus and aberrant embryonal cartilagenous rests (4,7,(9)(10)(11)(12)(13)(14)(15)(16). In the case of primary intraparenchymal chondrosarcoma, misplaced embryonal cartilagenous rests or primitive multipotential mesenchymal cells in leptomeningeal sheaths around vessels or the vessel walls have been suggested to be origins without definitive evidence (3,5,7,8,10,(17)(18)(19)(20)(21).…”

Long-Term Management of Craniofacial Osteosarcoma

“…The incidence of osteosarcoma is higher in men than in women with a ratio of 3:2. 8 For the special anatomic location and associated complexity, it is more difficult to achieve both parts: adequate resection margin and good functional/cosmetic result, especially when treating primary malignant bone tumors of the jaw. The current treatment of osteosarcoma involves an integrated strategy incorporating chemotherapy and surgery.…”

Rhabdomyosarcoma and Other Pediatric Temporal Bone Malignancies

“…4). 1,24,25 Based on the reported cases of temporal bone RMS, it seems that these tumors can originate from the middle ear, external auditory canal, or mastoid. There seems to be a tendency toward early involvement of the fallopian canal and subsequent intracranial extension by perineural spread through the internal auditory canal.…”

“…25 NRMSS accounts for only 7% of all head and neck malignancies in children, with a mere 10% of these having a skull base component. 21 Some of the NRMSSs that have been reported to occur in the ear and temporal bone of children and adolescents include chondrosarcoma, 34,35 chordoma, 36 osteosarcoma, 37,38 Ewing sarcoma, 39 fibrosarcoma, angiosarcoma, and chloroma (granulocytic sarcoma) 40 ; however, determination of the mesenchymal cell of origin is not always possible.…”