Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases

Mantilla, José G.; Xu, Haodong; Ricciotti, Robert W.

doi:10.1007/s12105-019-01106-1

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Other possible reason could be reporting bias in various case reports and series in our study. Male patients were affected four times more commonly than females in the present study, which closely corroborates with SEER data as well as in large single institutional series of laryngeal sarcoma 6‐8 Only 5% cases had history of smoking in our analysis. Hence, it appears reasonable to consider a differential of LSTS whenever a non‐smoker is being evaluated for hoarseness without any palpable neck node and a lesion is found in the larynx.…”

Section: Discussionsupporting

confidence: 92%

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

et al. 2021

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Background Laryngeal sarcoma is rare. We performed a systematic review and individual patient analysis to evaluate the patterns of care, prognostic factors, and role of radiotherapy in laryngeal soft tissue sarcoma. Methods A systematic search on PubMed and Google scholar was done. An individual patient data analysis was done. Results Of the 300 cases of laryngeal sarcoma, 80% underwent surgery. 44% underwent larynx preservation surgery and 25% received radiotherapy with surgery. Median progression free survival (PFS) was 48 months and overall survival (OS) of 224 months for the entire cohort. Patients with large primary, cartilage invasion, and positive margins had numerically worse PFS. Cartilage invasion and primary tumor size >3 cm were the most common risk factors for adjuvant radiation therapy. Patients receiving radiotherapy were not associated with better survival. Conclusion Laryngeal sarcoma associated with a good survival. Larynx preservation surgery is feasible in nearly half patients. Adjuvant radiotherapy may be warranted in patients poor prognostic factors.

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Section: Discussionsupporting

confidence: 92%

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

et al. 2021

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“…These proximal oesophageal tumours usually arise near the larynx, where well-differentiated/de-differentiated liposarcoma is one of the most commonly occurring sarcomas after chondrosarcoma. 26,27 Ultimately, work-up for well-differentiated liposarcoma should be initiated in tumours with the gross and histological appearances of giant fibrovascular polyp. To confirm the diagnosis of well-differentiated liposarcoma, MDM2 FISH or MDM2 and CDK4 immunohistochemistry can be performed ( Figure 4D).…”

Section: Well-differentiated Liposarcoma ('Giant Fibrovascular Polyp')mentioning

confidence: 99%

“…The authors concluded that many tumours previously diagnosed as giant fibrovascular polyp represent well‐differentiated liposarcomas. These proximal oesophageal tumours usually arise near the larynx, where well‐differentiated/de‐differentiated liposarcoma is one of the most commonly occurring sarcomas after chondrosarcoma 26,27 . Ultimately, work‐up for well‐differentiated liposarcoma should be initiated in tumours with the gross and histological appearances of giant fibrovascular polyp.…”

Section: Well‐differentiated Liposarcoma (‘Giant Fibrovascular Polyp’)mentioning

confidence: 99%

Recent developments in gastroesophageal mesenchymal tumours

Papke

Hornick

2020

Histopathology

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The pathologist’s approach to gastroesophageal mesenchymal tumours has changed dramatically during the last 25 years. In particular, gastrointestinal stromal tumour (GIST) has evolved from a wastebasket mesenchymal tumour category to a precisely defined entity with an increasingly detailed genetic subclassification. This subclassification has brought gastrointestinal mesenchymal neoplasia into the realm of precision medicine, with specific treatments optimised for particular genetic subtypes. Molecular genetic data have also greatly improved our understanding of oesophageal mesenchymal tumours, including the discovery that so‐called ‘giant fibrovascular polyps’ in fact represent a clinically distinctive presentation of well‐differentiated liposarcoma. Here, we will focus on gastroesophageal mesenchymal tumours for which there have been recent developments in classification, molecular genetics or tumour biology: granular cell tumour, ‘giant fibrovascular polyp’/well‐differentiated liposarcoma, plexiform fibromyxoma, gastroblastoma and, of course, GIST.

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“…The important features of laryngeal osteosarcoma are summarized in Table 1 . A summary of the reported laryngeal osteosarcoma cases is shown in Table 2 , with the first case published in 1966 [ 3 ] and the last in 2019 [ 38 ]. Table 3 provides a description of the cases that have been reported without pathological documentation.…”

Section: Resultsmentioning

confidence: 99%

Characteristics of Laryngeal Osteosarcoma: A Critical Review

et al. 2020

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Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a lack of information on the characteristics of laryngeal osteosarcoma. Thus, we sought to critically review the existing world literature on laryngeal osteosarcoma in order to develop a more accurate clinicopathological profile of this malignancy. Laryngeal osteosarcoma has a predilection for elderly male patients, as 87% were male in the present series and the mean age was 62 years (range 32-80), and without a direct association with tobacco exposure. Osteosarcoma of the larynx is typically a highly malignant neoplasm that metastasizes early, has a propensity for hematogenous spread and also has a marked tendency to recur. Twelve (41%) out of the 29 cases in the present review with follow-up data had metastatic disease. The aspects that distinguish osteosarcoma from its differential diagnostic alternatives are discussed in this review.

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Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases

Cited by 12 publications

References 26 publications

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

Recent developments in gastroesophageal mesenchymal tumours

Characteristics of Laryngeal Osteosarcoma: A Critical Review

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