Primary Rosai-Dorfman Disease of the Bone in a Patient With History of Breast Cancer

Mannelli, Lorenzo; Monti, Serena; Love, Jason E.; Kussick, Steven J.; McLuen, Anna; Behnia, Fatemeh

doi:10.1097/rlu.0000000000000595

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…There are few reported cases of RDD in the bone simulating metastatic cancer 2 and only 1 case simulating metastatic breast cancer similar to our patient 3 . In our patient's case, with a known history of metastatic breast cancer, following the dermatologic clue to perform additional systemic workup to distinguish between new metastases versus RDD bone lesions was critical to her care because it led to drastically different management decisions and averted the potential long-term morbidity associated with further aggressive treatment of presumed metastatic breast cancer.…”

Section: Discussionsupporting

confidence: 76%

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Rosai–Dorfman disease simulating metastatic breast carcinoma

Briones

Chan

et al. 2019

JAAD Case Reports

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Section: Discussionsupporting

confidence: 76%

“… 1 RDD has several postulated etiologies, although none have been definitively proven. It has been reported to mimic various metastatic cancers, 2 including 1 reported case of RDD simulating metastatic breast cancer 3 . We present a patient with RDD of the skin and bone simulating presumed recurrent metastatic breast cancer.…”

Section: Introductionmentioning

confidence: 93%

Rosai–Dorfman disease simulating metastatic breast carcinoma

Briones

Chan

et al. 2019

JAAD Case Reports

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“…These articles were published from 1976 to 2020, and 42 articles (67.7%, 42/62) were published after 2010. Twelve included studies had high ROB [ 13 , 16 – 18 , 31 , 34 , 46 , 48 , 49 , 53 , 56 , 57 ], whilst 50 other studies had low ROB. The cohort included 45 males and 24 females, at a ratio of 1.9/1.…”

Section: Resultsmentioning

confidence: 99%

“…According to our study, 93.6% of cases whose initial symptoms were spine-related could not be correctly recognized until postoperative pathological examination. Computed tomography (CT)-guided biopsy results were recorded in six cases; three cases (50.0%) failed to make a definite and correct diagnosis [ 17 , 24 , 31 , 34 , 57 , 62 ]. The failure rate was relatively high in the included reports.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of Rosai-Dorfman disease of the spine: a systematic literature review

Wei

Liu

et al. 2021

Syst Rev

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Purpose To review and summarize the clinical features, diagnosis, treatment strategies, and prognosis of spinal Rosai-Dorfman disease (RDD). Methods RDD is also termed as sinus histiocytosis with massive lymphadenopathy. We searched the databases of PubMed, Elsevier ScienceDirect, SpringerLink, and OVID. The keywords were Rosai-Dorfman disease and spine/central nervous system. Research articles and case reports with accessibility to full texts regarding spinal RDD were eligible for the inclusion. A total of 62 articles were included, and they contained 69 cases. We extracted the information of interest and analyzed them using SPSS statistics package. Results The average age was 33.1 ± 18.3 years. The ratio of males to females was 1.9/1. Overall, 63 cases presented with spine-related symptoms. A total of 27 cases (39.1%) had multi-organ lesions, and 12 cases had records of massive lymphadenopathy. Among 47 cases who first manifested spine-related symptoms, 93.6% were preoperatively misdiagnosed. The disease had a predilection for cervical spine (38.8%) and thoracic spine (40.3%). 62.9% of lesions were dura-based. Surgery remained the mainstream treatment option (78.8%), with or without adjuvant therapies. Total lesion resection was achieved in 34.8% of cases. The rate of lesion recurrence/progression was 19.5%, which was marginally lower for total resection than for non-total resection. Conclusion Spinal RDD has no pathognomonic clinical and imaging features. Most cases first present with spine-relevant symptoms. Massive lymphadenopathy is not common, but a tendency for multi-organ involvement should be considered. Spinal RDD has a high recurrence rate; thus, total resection is the treatment of choice. Adjuvant therapies are indicated for multi-organ lesions and residual lesions. A wait and watch strategy is recommended for asymptomatic patients. Herein, a workflow of diagnosis and treatment of the spinal RDD is established.

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“…RDD is often misdiagnosed as a tumor because its imaging findings are difficult to distinguish from tumors, especially when RDD invades uncommon sites. Generally speaking, the diagnosis of RDD requires the assistance of histopathology and cannot be confirmed solely by the patient's symptoms and imaging examination [9–11] …”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman disease with spine involvement

Jiang

Song²,

Lin³

et al. 2022

Medicine

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Rationale:Rosai-Dorfman disease (RDD) is a rare, benign, self-limiting disease, also known as sinus histiocytosis with giant lymphadenopathy. Skeletal involvement is rare, and this isolated bone lesion usually occurs in adults with no other symptoms. It is estimated that 0.6% to 1% of RDD cases have isolated or complicated spinal lesions, which may occur in the bone, dura, and spinal parenchyma, but spinal RDD has no pathologic clinical or imaging features.Patient concerns:A 25-year-old woman presented with complaints of low back pain without obvious causes for a month.Diagnosis:RDD with spinal involvement.Interventions:Resection of the spinous process of the third lumbar spine was performed under epidural anesthesia.Outcomes:At the time of discharge, the patient had no problems with autonomous activities and reported no discomfort. We also followed up the patient at 12 and 36 months after surgery, and the patient reported no discomfort, inconvenience, and no recurrence of symptoms. Imaging examination 1 year after surgery showed no recurrence.Lesson:This case suggests that surgery for RDD with spinal involvement may not require internal fixation.

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Primary Rosai-Dorfman Disease of the Bone in a Patient With History of Breast Cancer

Cited by 12 publications

References 13 publications

Rosai–Dorfman disease simulating metastatic breast carcinoma

Rosai–Dorfman disease simulating metastatic breast carcinoma

Diagnosis and treatment of Rosai-Dorfman disease of the spine: a systematic literature review

Rosai-Dorfman disease with spine involvement

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