Primary Rosai‐Dorfman disease of the central nervous system: A clinical, histological, and molecular appraisal
Mayur Parkhi,
Debajyoti Chatterjee,
Dharambir Kashyap
et al.
Abstract:Rosai‐Dorfman disease (RDD) is characterized by clonal proliferation of S‐100 positive histiocytes and variable emperipolesis. It commonly affects cervical lymph nodes. Central nervous system (CNS) involvement is extremely rare. We attempted to evaluate the Cyclin D1 expression and frequency of KRAS and BRAF mutations in the RDD involving the CNS. All patients with histopathologically diagnosed RDD involving CNS were recruited from 2011 to 2022. All cases were subjected to immunohistochemistry for CD68, CD163,… Show more
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