Primary Retroperitoneal Soft-Tissue Sarcomas

Abstract

Of the 98 soft-tissue sarcomas treated between 1973-1978, 12 were retroperitoneal in origin. Fifty percent underwent one to three previous surgical procedures. All patients were operated on. In 75% (nine out of 12), the tumor was completely resected. The operative mortality for total tumor excision was 11 % . There were five liposarcomas, three leiomyosarcomas, two neurofibrosarcomas, and one synovial sarcoma and one unclassified sarcoma. Six of the 12 patients survived five years and three (25%) were alive without evidence of disease at 5 years. Three of the completely resected group received no further treatment; 2/3 survived 5 years; three had postoperative chemotherapy; 3/3 survived; and three others had radiation and chemotherapy subsequent to surgery; all three have died. The two most important prognostic factors were tumor grade and surgical excision. Only one patient with high grade tumor survived. Total surgical excision of the tumor offers the only hope for cure. Aggressive surgery in treating retroperitoneal soft part sarcomas is strongly recommended. From 1973From -1978, 98 patients with soft-part sarcomas were located in the retropritoneum* During the Same period, a total of 30 patients with primary malignant MATERIALS AND METHODS

Synovial Sarcoma at an Unusual Location- Scrotum

“…9 Prognosis of synovial sarcoma has been related to tumour size, 10,11 biphasic histology, 7,10,11 SSY-SSX2 gene fusion and negative resection margins. 1 Surgery is the mainstay of treatment. Chemotherapy and radiation therapy should be considered as additional treatment options or may be utilised in cases of relapse.…”

“…With the advent of immunohistochemistry and molecular techniques, cases of synovial sarcomas have been reported in an unusual location including the head and neck, mediastinum, lung, abdominal wall, intra-abdominal, kidney and retroperitoneum. 1,2 Although, SS is named because of the histological resemblance to the synovium, joints are rarely involved and the origin has been attributed to pluripotent mesenchymal cells. [1] The monophasic SS consisting solely of sarcomatous components is often diagnostically challenging.…”

“…1,2 Although, SS is named because of the histological resemblance to the synovium, joints are rarely involved and the origin has been attributed to pluripotent mesenchymal cells. [1] The monophasic SS consisting solely of sarcomatous components is often diagnostically challenging. The differential diagnosis depends on the type of SS.…”

Unusual Case of Retropancreatic Mass Involving Portal Vein

“…Retroperitoneal leiomyosarcoma occurs most commonly in [2][3][4][5] the fifth to seventh decade. Retroperitoneal tumors typically have vague presenting symptoms.…”

“…Leiomyosarcoma 1 consists of 5% to 10% of all soft tissue sarcoma. 10% to 20% [2][3][4][5][6] of soft tissue sarcomas occur in the retroperitoneum. In a population-based series reported in the Surveillance, Epidemiology, and End Results (SEER) database, the average annual incidence of retroperitoneal sarcomas was 7 approximately 2.7 cases per million population.…”