Primary Retroperitoneal Mucinous Cystadenocarcinoma: A Case Report and Review of the Literature

Dierickx, Inge; Jacomen, G; Schelfhout, Vanessa; Moerman, Philippe; Corveleyn, P.; Spiessens, T; Amant, Frédéric; Berteloot, Patrick

doi:10.1159/000316268

Cited by 15 publications

(13 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, an appropriate diagnosis is mandatory, but the differentiation of a mucinous from a nonmucinous cyst and, especially, the quantification of its malignant potential, are very difficult tasks because all imaging techniques, including MRI, have been inconsistent [14,15,16]. It is estimated that MRI only has an accuracy that varies between 20 and 80% [17].…”

Section: Discussionmentioning

confidence: 99%

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Tica

Săftoiu

et al. 2013

Gynecol Obstet Invest

View full text Add to dashboard Cite

Pancreatic mucinous cystic neoplasms are uncommon and their occurrence in pregnancy is extremely rare. The authors report the unique case of a newborn weighing 3,620 g, delivered vaginally with no complications by a patient with a large ‘silent' pancreatic mucinous cystic neoplasms, and analyze the very few other reports. With no available protocol, this case highlights an interesting dilemma on the management of pregnancy and delivery as well on the timing of pancreatic surgery. Despite its limitations, MRI remains the most accurate investigation either for differentiating the mucinous from nonmucinous cysts or for evaluating the malignancy, but echography is also very useful. Without symptoms, all low-grade malignant potential tumors, independent of the moment of their diagnosis during pregnancy, should be resected 2-3 months after delivery and we believe that the best option is a term vaginal birth, even in the presence of a large cyst and large fetus. On the contrary, all high-grade malignant potential tumors, discovered in the first two trimesters of pregnancy should be resected during the second trimester, and followed by a vaginal delivery at term. If high-grade malignant potential tumor is diagnosed in the third trimester, an early vaginal delivery followed by surgery is recommended. Finally, the patient's preference is crucial.

show abstract

Section: Discussionmentioning

confidence: 99%

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Tica

Săftoiu

et al. 2013

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…The present case is the first reported nodule in a benign mucinous cystadenoma (Table 4) (3,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Mural nodules in PRMTs are exceptionally rare, with only 12 well-documented cases, 10 of which were in cystadenocarcinomas and 2 in borderline tumors.…”

Section: Primary Retroperitoneal Mucinous Cystadenomamentioning

confidence: 72%

“…Laparoscopy was performed in only 4 of the cases reported in the literature (10,18,25,31). SLMNs do not show an adverse effect on the prognosis, although mucinous tumors with malignant mural nodules are associated with a poor prognosis (3,36,37,40,49,59). SLMNs do not show an adverse effect on the prognosis, although mucinous tumors with malignant mural nodules are associated with a poor prognosis (3,36,37,40,49,59).…”

Section: Differential Diagnostic Considerationsmentioning

confidence: 99%

Primary Retroperitoneal Mucinous Cystadenoma With a Sarcoma-like Mural Nodule

Demirel¹,

Gün²,

Küçükodacı³

et al. 2013

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Primary retroperitoneal mucinous cystadenomas (PRMCs) are extremely rare tumors and their association with sarcoma-like mural nodules (SLMNs) has not been described thoroughly. The aim of this study is to characterize the gross and microscopic features and the immunohistochemical profile of the first case of PRMC with SLMN and to discuss the differential diagnosis of SLMNs. The literature related to primary retroperitoneal mucinous tumors is reviewed in an attempt to clarify the histogenesis of the epithelial and sarcomatoid components of the associated mural nodules. A 34-yr-old woman presented with a 14-cm retroperitoneal cystic lesion with a 6-cm mural nodule. An immunohistochemical study with a panel of 19 antibodies and a histochemical study for mucin stains were performed. The epithelial component of the PRMC showed positive staining for cytokeratin (CK) 7, CK AE1/3, epithelial membrane antigen, carcinoembryonic antigen, and calretinin. The neoplasm was not immunoreactive for CK 20, CK 5/6, and the other antibodies used in this study. In addition, it stained positively for mucin by mucicarmine, periodic acid-Schiff, and Alcian blue. The stromal cells of the cyst showed estrogen receptor positivity. SLMN cells were negative for all CKs and other epithelial markers used in the study, but they showed diffuse positive staining for vimentin and CD68, and positive staining for Ki-67 was demonstrated in 25% of these cells. The immunohistochemical and histochemical profiles of PRMC were similar to those of ovarian mucinous neoplasms and the mesothelium. The formation of SLMNs seems to be related to subepithelial hemorrhage and some reactive epithelial changes near the mural nodules. The specific immunohistochemical and morphologic features of SLMNs are helpful in differentiating them from malignant mural nodules, including true sarcomas, osteoclast-rich undifferentiated carcinomas, and carcinosarcomas. Such a differentiation is critical in view of its significant impact on the management of these neoplasms, particularly in young patients who desire to preserve their fertility.

show abstract

“…Therefore, radical tumor excision is clearly mandatory. Radical resection without rupture is the standard therapy and the most important prognostic tool [46], but whether lymphadenectomy or adjuvant chemotherapy provide benefit is still controversial [11, 12, 19, 21, 27, 29, 31, 36]. …”

Section: Discussionmentioning

confidence: 99%

The long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report

et al. 2017

View full text Add to dashboard Cite

BackgroundPrimary retroperitoneal mucinous cystadenocarcinoma (PRMC) is extremely rare, and its biological behavior, pathogenesis, optimum treatments, and prognosis remain to be elucidated. We herein report a case of PRMC with an 80-month follow-up.Case presentationA 29-year-old woman was diagnosed with unknown retroperitoneal tumor with benign right ovarian cyst and uterine fibroids, and she underwent laparotomy. The tumor was completely resected with a subsequent histopathological diagnosis of primary retroperitoneal mucinous cystadenocarcinoma (PRMC). Eighty months after surgery, she remains recurrence-free.ConclusionPRMC is an extremely rare tumor. Only around 60 cases have so far been published in the literature. The preoperative diagnosis of PRMC is difficult, and a definitive diagnosis can usually only be made based on the findings of histopathological examinations after surgery. Presently, only radical resection is useful for both diagnostic and therapeutic purposes. The optimal long-term management after surgery is still not well established. Further studies on PRMC are therefore needed to elucidate the etiology and establish effective treatments.

show abstract

Primary Retroperitoneal Mucinous Cystadenocarcinoma: A Case Report and Review of the Literature

Cited by 15 publications

References 68 publications

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Primary Retroperitoneal Mucinous Cystadenoma With a Sarcoma-like Mural Nodule

The long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report

Contact Info

Product

Resources

About