Primary retroperitoneal liposarcoma: a rare case report

Abstract

Primary retroperitoneal liposarcoma (PRPLS) is a rare malignant tumor with a low incidence. A 34-year-old female patient presented to our department with abdominal pain, nausea, and vomiting for 2 days. Abdominal computed tomography (CT) indicated a huge mass between the liver and kidney, with a clear boundary and measuring approximately 202 mm × 155 mm ×106 mm. The mass was considered a retroperitoneal lipoma or liposarcoma. The entire tumor was completely resected without auxiliary injury, and histopathology of the resected specimen indicated liposarcoma. The patient recovered well and was discharged from our department on the 6th postoperative day. No signs of relapse were seen during 1-year of follow-up. PRPLS is rare and without obvious symptoms in the early stage. CT plays a vital role in the diagnosis of PRPLS, and surgical resection is considered the most suitable treatment. Radiotherapy and chemotherapy might also be treatment options to improve the overall survival of PRPLS patients.

Retroperitoneal liposarcoma: case of a giant tumour inside the abdomen

“…8 In the case of this patient, the tumour analysis indicated a well-differentiated subtype, which meant a good prognosis histologically. Tumours of similar grade have been previously described by Evola et al, 9 and Wang et al 7 CT imaging has a role in both assessment and grading of liposarcomas. Well-differentiated tumours tend to display a high attenuation of fat and minimal soft tissue components, calcifications, and nodular enhancing septations.…”

“…6 About 35% of retroperitoneal liposarcomas originate from perirenal fat. 7 There is a predilection for the age group of 60-70 years, with males affected a little more than females. 5 Besides the origin and location, another way to classify liposarcomas, is their histological features.…”

Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report

“…The clinical manifestations of early RPLPS are usually not significant and are often detected at an advanced stage, characterized by a large abdominal mass (13). Many patients do not experience any symptoms, but if present, they may include nonspecific symptoms like flank pain, early satiety, or general discomfort (14).…”

Liposarcoma retroperitoneal: reporte de un caso y revisión de la literatura

“…Recientemente se han descrito alteraciones genéticas y moleculares en los liposarcomas, con mayor frecuencia amplificaciones en la region 12q13 -15 que implican a los genes MDM2, CDK4 y que tienen implicaciones no sólo para establecer el diagnóstico de malignidad, sino para en el futuro delimitar mejor el pronóstico de estos tumores. Pueden formarse en cualquier región donde haya grasa, aproximadamente 30% de estos tumores se desarrollan en la cavidad retroperitoneal y el 35% se originan de grasa perirrenal 1,2 .…”

“…Además, en pacientes con riesgo de resección incompleta y en los que se planifique radioterapia neoadyuvante, es obligatoria la confirmación histológica previa al tratamiento; esta se sugiere que sea por aspiración con aguja guesa o fina guiada por imágenes y se prefiere a los enfoques abiertos o laparoscópicos, que pueden estar asociados con un mayor riesgo de diseminación del tumor y comprometer la estrategia quirúrgica futura al alterar los planos tisulares. Los marcadores inmunohistoquímicos, también ofrecen confirmación diagnóstica, tales como CD68, MDM2, CDK4 y S100 1,2,3,4 .…”