Primary Renal Synovial Sarcoma and Clinical and Pathological Findings: a Systematic Review

Blas, Leandro; Roberti, Javier

doi:10.1007/s11934-021-01038-w

Cited by 12 publications

(32 citation statements)

References 92 publications

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“…Surgery was the treatment of choice, with adjuvant chemotherapy; most frequently ifosfamide-based, combined with doxorubicin or epirubicin (9). The median survival time was 34 months, with a mortality rate of 29% and a recurrence rate of 39.8% (9). In our report, the patient underwent a right open radical nephrectomy with six cycles of docetaxel and gemcitabine as adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 74%

“…The most recent systemic review included 96 studies with 185 cases of PSS of the kidney and showed that surgery, with adjuvant chemotherapy, was the most common treatment. The ifosfamide-based treatment was most frequently used, combined with doxorubicin or epirubicin (9). In the present case, a man who presented with bleeding PSS of the kidney was successfully treated by open radical nephrectomy followed by a docetaxel/gemcitabine adjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 84%

“…Blas and Roberti (2021) reviewed 96 studies, including 185 clinical cases of PSS of the kidney, and found that the predominant location of the tumour was the right kidney. Surgery was the treatment of choice, with adjuvant chemotherapy; most frequently ifosfamide-based, combined with doxorubicin or epirubicin (9). The median survival time was 34 months, with a mortality rate of 29% and a recurrence rate of 39.8% (9).…”

Section: Discussionmentioning

confidence: 99%

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Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock

Alzahrani

Albqami

Alkhayal

et al. 2021

jkcvhl

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Primary synovial sarcoma (PSS) of the kidney is considered the rarest type of all renal sarcomas with specific chromosomal translocation t (X; 18) (p11.2; q11.2). We report the case of a 65-year-old man with no medical conditions who presented to the emergency department with sudden severe right flank pain associated with haemodynamic instability and haemorrhagic shock. Computed tomography (CT) of the abdomen and pelvis revealed a right renal mass. A right open radical nephrectomy was performed. Histopathology revealed a monophasic synovial sarcoma. The patient received six cycles of docetaxel and gemcitabine as adjuvant chemotherapy. No sign of recurrence was seen on a follow-up CT urogram. This rare tumour often presents atypically, and clear guidelines regarding appropriate treatment are lacking. Our case showed that treatment with docetaxel/gemcitabine after an open radical nephrectomy is promising.

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock

Alzahrani

Albqami

Alkhayal

et al. 2021

jkcvhl

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“…The patients with primary renal synovial sarcoma usually present with hematuria (46.3%), either alone or in combination with other symptoms like pain (43%) or palpable mass (37%) which results in common misdiagnosis of renal cell cancer. The most common sites of metastasis are lung, liver and bone [8]. There are no definite radiological characteristics which can differentiate renal synovial sarcoma from renal cell cancer preoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…With common consensus surgical extirpation in resectable non metastatic cases is considered the therapy of choice. Few case reports have also described doxorubicin and ifosfamide in the neoadjuvant and adjuvant setting [8]. Chediak et al reported complete resolution of a metastatic renal synovial sarcoma with surgery and doxorubicin and ifosfamide chemotherapy [2].…”

Section: Discussionmentioning

confidence: 99%

Primary synovial sarcoma of kidney: a rare case report with review of literature

et al. 2022

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Background Synovial sarcoma is a rare type of sarcoma with a predilection for extremities in young adults. Very rarely this tumor can originate from kidney. Case presentation A 22-year-old female presented to us with complaints of right flank pain and a large mass in the right side of abdomen for the last 6 months. A provisional diagnosis of renal cell carcinoma was made and right radical nephrectomy was done. However on histopathological examination the tumor was composed of spindle cells arranged in hemangiopericytoma-like vascular pattern. Immunohistochemistry and FISH confirmed the diagnosis of synovial sarcoma of kidney. The patient had no signs of recurrence or metastasis at six months of follow-up. Conclusion Renal synovial sarcomas, though rare, should be considered as a differential in young adults who present with extremely large renal mass. Surgical extirpation is the treatment of choice. Ifosfamide- and doxorubicin-based chemotherapy can be given in non resectable and metastatic cases.

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Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

Della Giustina,

Sartori,

Laurino

2024

J Med Imaging Intervent Radiol

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Just less than 200 cases of primary renal synovial sarcoma (PRSS) are known, a very rare neoplasm of the kidney. The diagnosis can be very challenging because of its similarity with other neoplasms, and is based on anatomopathological analyses, especially immunohistochemistry and cytogenetics. Due to the rarity, there are no standard protocols for treatment, although radical nephrectomy is considered the primary treatment and can be associated or not with chemotherapy. We present a case of PRSS with negative immunohistochemistry: the importance of both methods for a correct diagnosis is underlined, and a literature review of this rare entity is presented.

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Primary Renal Synovial Sarcoma and Clinical and Pathological Findings: a Systematic Review

Cited by 12 publications

References 92 publications

Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock

Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock

Primary synovial sarcoma of kidney: a rare case report with review of literature

Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

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