Primary Renal Synovial Sarcoma

Abstract

Primary Renal Sarcoma is rare tumor comprising only 1% of all renal tumours. Synovial sarcomas are generally deep-seated tumors arising in the proximity of large joints of adolescents and young adults and account for 5–10% of all soft tissue tumours. Primary synovial sarcoma of kidney is rare and has poor prognosis. It can only be diagnosed by immunohistochemistry. It should be considered as a differential in sarcomatoid and spindle cell tumours. We present a case of 33-year-old female, who underwent left sided radical nephrectomy for renal tumour. Histopathology and genetic analysis diagnosed it to be primary renal synovial sarcoma. Patient underwent radiation therapy and 2 years follow up is uneventful. A brief case report with review of literature is presented.

A rare case report of recurrent primary intra-abdominal synovial sarcoma: An unusual manifestation

“…Primary renal sarcomas are rare neoplasms that account for 1% of all renal tumors [11] . The sarcomas that involve the kidney include rhabdomyosarcoma, malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, hemangiopericytoma, and rarely synovial sarcoma.…”

Primary Renal Synovial Sarcoma Case Series: Clinical Profile and Management of a Rare Entity

“…High-dose ifosfamide has been used in conjugation with surgery in localized or locally advanced soft tissue SS, and favorable results have been reported [8]. Radiotherapy has been shown to be effective in Bcl-2-negative patients [9]. Surgery forms the mainstay of treatment, and adjuvant chemotherapy usually incorporates ifosfamide-based regimens [9].…”

“…Radiotherapy has been shown to be effective in Bcl-2-negative patients [9]. Surgery forms the mainstay of treatment, and adjuvant chemotherapy usually incorporates ifosfamide-based regimens [9]. All patients in this study were nonmetastatic at presentation and were treated by radical nephrectomy and renal vein/ IVC thrombectomy.…”

SS18-SSX Expression in a Contemporary Cohort of Primary Renal Synovial Sarcoma: A Multi-Institutional Experience of Fourteen Patients

“…5,6 Primary renal synovial sarcoma is one of the rarest types of sarcomas of kidney and comprises 2% of all malignant renal tumors and 1% of all synovial sarcomas across the anatomic sites. 7 The first case of primary renal synovial sarcoma was reported by Argani et al in 2000 and to date, 88 case reports and 23 case series, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] with only two case series consisting of more than 14 tumors, have been reported in the literature. 8,9 The most common presenting symptoms include hematuria, pain, and palpable mass.…”