Primary renal small cell carcinoma: A case report

Abstract

BACKGROUND Small cell carcinoma (SCC) is a malignant tumour that is frequently accompanied by extensive metastasis. Primary renal SCC has typical characteristics related to SCC and is extremely rare, with no uniform treatment standard. Clinical treatment is mainly based on the literature. Here we report the diagnosis and treatment of an interesting case of primary renal SCC. CASE SUMMARY We report a tortuous course of treatment for a 68-year-old man. Four years before diagnosis, the patient developed continuous gross haematuria, during which he underwent several ureteral biopsies, ureteral stricture relief, and urine exfoliated cell examinations; however, SCC was not confirmed. One month before radical resection of the renal pelvic carcinoma, the severe haematuria recurred. Computed tomography revealed transitional cell carcinoma in the right kidney and right upper ureter. A preoperative examination exluded the possibility of a pulmonary origin of the tumour, and primary renal SCC was diagnosed. The postoperative pathology findings were suggestive of SCC. The patient was treated with combined chemotherapy but died of tumour progression at 7 mo postoperative. CONCLUSION Our patient's disease onset in the context of a succession of regular testing and the fact that it occurred so quickly with perirenal encroachment immediately after diagnosis reveals the cruel and unforgiving side of the disease. Furthermore, patients with poor comprehensive treatment results require new treatment regimens.

Renal B‐lymphoblastic lymphoma with hematuria as the first symptom diagnosed in urine cytology: A case report and literature review

“…6 Neuroendocrine carcinomas (NEC), especially small-cell carcinoma (SmCC), affect the kidneys and can be misdiagnosed as lymphoma due to their overlapping morphology. 7 The urine cytology of SmCC may appear in a loosely cohesive cluster or even a predominantly discohesive pattern. 8 This morphology may raise the differential diagnosis of lymphoma.…”