Primary Renal Lymphoma: Long-Term Results of Two Patients Treated with a Chemotherapy + Rituximab Protocol

Vázquez-Alonso, Fernando; Puche-Sanz, Ignacio; Sánchez‐Ramos, Cristina; Flores-Martín, José Francisco; Vicente-Prados, Javier; Cózar-Olmo, J.M.

doi:10.1155/2012/726424

Cited by 17 publications

(22 citation statements)

References 7 publications

(9 reference statements)

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“…Indirect signs that may indicate an RCC include the following: the presence of calcifications, venous thrombosis, or an obstructive mass effect over the renal vessels or urinary tract. [ 6 ] These signs are indirect, and it is always required to confirm the diagnosis with a percutaneous biopsy. MRI and CT are considered to have the same accuracy for detection and characterization of the most renal lesion.…”

Section: Discussionmentioning

confidence: 99%

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Primary renal cell lymphoma: Case report, diagnosis, and management

Thawani

Amar

Patowary

et al. 2017

Indian J Med Paediatr Oncol

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The symptoms of primary renal lymphoma (PRL) may mimic a renal cell carcinoma. Since the diagnosis is mostly after a radical nephrectomy, we recommend a percutaneous biopsy or cytology from the renal mass in patients who have features suggestive of a lymphoma. A magnetic resonance imaging may give an image more specific for a lymphoma. There are no clinical trials for the treatment of PRL, but all previously published case reports used R-CHOP and a few patients did better than the median survival of 6 months.

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Section: Discussionmentioning

confidence: 99%

“…There are no clinical trials on the treatment of PRL, but all the case reports we reviewed treated the patient with CHOP and rituximab. [ 3 6 7 10 11 ] The mean survival of the patient is known to be 6 months only. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Primary renal cell lymphoma: Case report, diagnosis, and management

Thawani

Amar

Patowary

et al. 2017

Indian J Med Paediatr Oncol

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“…Lymphomas are malignant neoplasms derived from lymphoid cells [1]. Lymphomas are classified into Hodgkin’s lymphoma (HL) and NHL with each one classified further into more than 30 subtypes [2].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Large B-cell Lymphoma Presenting as Bilateral Renal Masses: Successful Treatment with Dose-adjusted REPOCH (Rituximab, Etoposide, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin) Chemotherapy Regimen

Kaur¹,

Abughanimeh²,

Zafar³

et al. 2019

Cureus

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Diffuse large B-cell lymphoma (DLBL) is an aggressive type of non-Hodgkin lymphoma (NHL). Renal involvement in NHL is not uncommon in advanced stages; however, it is rare to have kidneys affected early in the course of the disease. Usual chemotherapy regimen for DLBL is rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone (R-CHOP). This is a case of a 50-year-old female diagnosed with DLBL who presented with bilateral renal involvement at disease onset and also underwent complete remission after six cycles of dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin (DA-REPOCH). Limited data exist on outcomes of patients with DLBL and renal disease who are treated with high-intensity regimes such as DA-REPOCH. It would be worth looking further into outcomes of DLBL patients especially with renal involvement on DA-REPOCH. Multicenter trials are required to demonstrate which of the two chemotherapy regimens (R-CHOP vs. DA-REPOCH) have better progression-free survival in this particular subset of patients.

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“…Although most authors believe that the CHOP protocol should be an elective option (as it is in Non-Hodgkin B cell Lymphoma). There is no agreement upon standard treatment approach (es) for PRL (12). Long term survival occasionally has been reported after combination of surgery with chemotherapy in case of unilateral involvement of kidney by PRL (13).…”

Section: Discussionmentioning

confidence: 99%

Primary Pleomorphic Mantle Cell Lymphoma of Kidney: A Case Report

2018

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Introduction: Primary renal lymphoma (PRL) is rare while secondary involvement of the kidney by lymphoma is not infrequent. All morphologic varieties of lymphoma can involve kidney. The most common reported PRL is large B cell lymphoma. To our knowledge no prior case of primary renal mantle cell lymphoma (MCL), pleomorphic variant, has been reported. Case Presentation: A 67-year-old male presented with right flank pain. On examination a right sided abdominal mass and a unilateral varicocele were detected. On imaging studies there was a large mass of right kidney without nodal or other organs involvement. He underwent right nephrectomy. On gross pathological evaluation, a deformed kidney which was almost totally involved by tumor with hemorrhagic nodular cut surfaces was identified. Histologic evaluation and immunohistochemistry (IHC) staining followed by fluorescence in situ hybridization (FISH) study for t (11; 14) (q 13; q 32) / CCND1 -IGH confirmed diagnosis of MCL, pleomorphic type. Finally the patient was admitted in another hospital for continuing the treatment and received chemotherapy there. After one year of initial diagnosis the patient is still alive. Conclusion: The aim of this manuscript was to highlight a possible presentation of primary MCL, pleomorphic variant.

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Primary Renal Lymphoma: Long-Term Results of Two Patients Treated with a Chemotherapy + Rituximab Protocol

Cited by 17 publications

References 7 publications

Primary renal cell lymphoma: Case report, diagnosis, and management

Primary renal cell lymphoma: Case report, diagnosis, and management

Diffuse Large B-cell Lymphoma Presenting as Bilateral Renal Masses: Successful Treatment with Dose-adjusted REPOCH (Rituximab, Etoposide, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin) Chemotherapy Regimen

Primary Pleomorphic Mantle Cell Lymphoma of Kidney: A Case Report

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